Expression levels of SIX1, ME2, and AP2M1 in adenoid cystic carcinoma and mucoepidermoid carcinoma
Cong-Cong Wu
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China
Contribution: Data curation, Formal analysis, Methodology, Writing - original draft
Search for more papers by this authorHao Li
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China
Contribution: Methodology, Software
Search for more papers by this authorYao Xiao
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China
Contribution: Methodology, Software
Search for more papers by this authorWei-Wei Deng
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China
Contribution: Project administration, Software
Search for more papers by this authorCorresponding Author
Zhi-Jun Sun
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China
Department of Oral and Maxillofacial-Head Neck Surgery, School & Hospital of Stomatology, Wuhan University, Wuhan, China
Correspondence
Zhi-Jun Sun, Department of Oral and Maxillofacial Head Neck Oncology, School and Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan, Hubei Province 430079, China.
Email: [email protected]
Contribution: Conceptualization, Funding acquisition, Project administration, Supervision, Validation, Writing - review & editing
Search for more papers by this authorCong-Cong Wu
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China
Contribution: Data curation, Formal analysis, Methodology, Writing - original draft
Search for more papers by this authorHao Li
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China
Contribution: Methodology, Software
Search for more papers by this authorYao Xiao
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China
Contribution: Methodology, Software
Search for more papers by this authorWei-Wei Deng
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China
Contribution: Project administration, Software
Search for more papers by this authorCorresponding Author
Zhi-Jun Sun
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China
Department of Oral and Maxillofacial-Head Neck Surgery, School & Hospital of Stomatology, Wuhan University, Wuhan, China
Correspondence
Zhi-Jun Sun, Department of Oral and Maxillofacial Head Neck Oncology, School and Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan, Hubei Province 430079, China.
Email: [email protected]
Contribution: Conceptualization, Funding acquisition, Project administration, Supervision, Validation, Writing - review & editing
Search for more papers by this authorZhi-Jun Sun is willing to handle correspondence at all stages of refereeing and publication, also postpublication.
Abstract
Objective
Adenoid cystic carcinoma (AdCC) and mucoepidermoid carcinoma (MEC) are the most frequent malignancies in the salivary glands. The purpose of this study was to explore the roles of sine oculis homeobox homolog 1 (SIX1), malic enzyme 2 (ME2), and AP-2 complex subunit mu (AP2M1) in AdCC and MEC, as well as the potential relationship between SIX1, ME2, AP2M1, and proliferation marker cyclin D1.
Material and methods
Immunohistochemistry was performed on human salivary gland tissue microarrays that contained 76 normal salivary glands (NSGs), 14 pleomorphic adenomas (PMAs), 81 AdCCs, and 52 MECs.
Results
We observed that the expression levels of SIX1 and ME2 were significantly elevated in AdCC and MEC when compared with NSG and PMA. In addition, we detected that AP2M1 was overexpressed in AdCC and MEC when compared with NSG. We also found that SIX1 and AP2M1 were positively associated with cyclin D1.
Conclusions
These results may prove that SIX1 and AP2M1 are involved in the proliferation of AdCC and MEC to cause tumor growth.
CONFLICT OF INTEREST
None.
Supporting Information
| Filename | Description |
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| odi13506-sup-0001-FigS1.tifTIFF image, 186.3 KB | Fig S1 |
| odi13506-sup-0002-FigS1-cap.pdfPDF document, 162.2 KB | Fig S1-cap |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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