ETIOLOGY AND PATHOPHYSIOLOGY
High-fat diets on the enteric nervous system: Possible interactions and mechanisms underlying dysmotility
Patricia Pereira Almeida,
Luisa Valdetaro,
Beatriz Bastos de Moraes Thomasi,
Milena Barcza Stockler-Pinto,
Ana Lúcia Tavares-Gomes,
Corresponding Author
Patricia Pereira Almeida
Postgraduate Program in Cardiovascular Sciences, Fluminense Federal University, Niterói, Brazil
Correspondence
Patricia Pereira Almeida, Experimental Nutrition Laboratory, Department of Nutrition and Dietetics, Fluminense Federal University, Rua Mário Santos Braga 30, Niterói, RJ 24020-140, Brazil.
Email: [email protected]
Search for more papers by this authorLuisa Valdetaro
Postgraduate Program in Neurosciences, Fluminense Federal University, Niterói, Brazil
Search for more papers by this authorBeatriz Bastos de Moraes Thomasi
Postgraduate Program in Neurosciences, Fluminense Federal University, Niterói, Brazil
Search for more papers by this authorMilena Barcza Stockler-Pinto
Postgraduate Program in Cardiovascular Sciences, Fluminense Federal University, Niterói, Brazil
Postgraduate Program in Nutrition Sciences, Fluminense Federal University, Niterói, Brazil
Search for more papers by this authorAna Lúcia Tavares-Gomes
Postgraduate Program in Neurosciences, Fluminense Federal University, Niterói, Brazil
Search for more papers by this authorPatricia Pereira Almeida,
Luisa Valdetaro,
Beatriz Bastos de Moraes Thomasi,
Milena Barcza Stockler-Pinto,
Ana Lúcia Tavares-Gomes,
Corresponding Author
Patricia Pereira Almeida
Postgraduate Program in Cardiovascular Sciences, Fluminense Federal University, Niterói, Brazil
Correspondence
Patricia Pereira Almeida, Experimental Nutrition Laboratory, Department of Nutrition and Dietetics, Fluminense Federal University, Rua Mário Santos Braga 30, Niterói, RJ 24020-140, Brazil.
Email: [email protected]
Search for more papers by this authorLuisa Valdetaro
Postgraduate Program in Neurosciences, Fluminense Federal University, Niterói, Brazil
Search for more papers by this authorBeatriz Bastos de Moraes Thomasi
Postgraduate Program in Neurosciences, Fluminense Federal University, Niterói, Brazil
Search for more papers by this authorMilena Barcza Stockler-Pinto
Postgraduate Program in Cardiovascular Sciences, Fluminense Federal University, Niterói, Brazil
Postgraduate Program in Nutrition Sciences, Fluminense Federal University, Niterói, Brazil
Search for more papers by this authorAna Lúcia Tavares-Gomes
Postgraduate Program in Neurosciences, Fluminense Federal University, Niterói, Brazil
Search for more papers by this authorPatricia Pereira Almeida, Luisa Valdetaro and Beatriz Bastos de Moraes Thomasi contributed equally to this study.
Funding information: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); State of Rio de Janeiro Carlos Chagas Filho Research Foundation (FAPERJ), Grant/Award Number: E-26/203.269/2017
Summary
Obesity is a chronic disease that affects various physiological systems. Among them, the gastrointestinal tract appears to be a main target of this disease. High-fat diet (HFD) animal models can help recapitulate the classic signs of obesity and present a series of gastrointestinal alterations, mainly dysmotility. Because intestinal motility is governed by the enteric nervous system (ENS), enteric neurons, and glial cells have been studied in HFD models. Given the importance of the ENS in general gut physiology, this review aims to discuss the relationship between HFD-induced neuroplasticity and gut dysmotility observed in experimental models. Furthermore, we highlight components of the gut environment that might influence enteric neuroplasticity, including gut microbiota, enteric glio-epithelial unit, serotonin release, immune cells, and disturbances such as inflammation and oxidative stress.
CONFLICT OF INTEREST
The authors declare that there are no conflicts of interest.
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