Association between bedtime and the prevalence of newly diagnosed non-alcoholic fatty liver disease in adults
Honglei Wang
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
Search for more papers by this authorYeqing Gu
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
Search for more papers by this authorLixiao Zheng
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
Search for more papers by this authorLi Liu
Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorGe Meng
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
Search for more papers by this authorHongmei Wu
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
Search for more papers by this authorYang Xia
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
Search for more papers by this authorXue Bao
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
Search for more papers by this authorHongbin Shi
Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorShaomei Sun
Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorXing Wang
Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorMing Zhou
Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorQiyu Jia
Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorKun Song
Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorQing Zhang
Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorCorresponding Author
Kaijun Niu
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
Correspondence
Kaijun Niu, MD, PhD, Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Heping District, Tianjin, China
Email: [email protected] or [email protected]
Search for more papers by this authorHonglei Wang
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
Search for more papers by this authorYeqing Gu
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
Search for more papers by this authorLixiao Zheng
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
Search for more papers by this authorLi Liu
Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorGe Meng
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
Search for more papers by this authorHongmei Wu
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
Search for more papers by this authorYang Xia
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
Search for more papers by this authorXue Bao
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
Search for more papers by this authorHongbin Shi
Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorShaomei Sun
Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorXing Wang
Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorMing Zhou
Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorQiyu Jia
Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorKun Song
Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorQing Zhang
Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorCorresponding Author
Kaijun Niu
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China
Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China
Correspondence
Kaijun Niu, MD, PhD, Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Heping District, Tianjin, China
Email: [email protected] or [email protected]
Search for more papers by this authorFunding information
This study was supported by grants from the 2016 Chinese Nutrition Society (CNS) Nutrition Research Foundation—DSM Research Fund (No. 2016-046), the Technologies development program of Beichen District of Tianjin (No. bcws2013-21 and bcws2014-05), and the National Natural Science Foundation of China (No. 91746205 and 81673166), China.
Abstract
Background & Aims
Emerging evidence supported that circadian clocks played an important role in the development and progression of non-alcoholic fatty liver disease (NAFLD). Bedtime is a strong regulator of circadian rhythms, implying that it may contribute to the onset of NAFLD. However, few studies have examined the association between bedtime and NAFLD. The purpose of the study was to determine whether late bedtime is associated with newly diagnosed NAFLD in an adult population.
Methods
This population-based study was performed in 22 807 participants in Tianjin, China. Bedtime was obtained from a self-administered questionnaire, and NAFLD was diagnosed by abdominal ultrasonography. Odds ratios of NAFLD for bedtime categories were estimated with multiple logistic regression models.
Results
The prevalence of newly diagnosed NAFLD was 18.8% in the present study. After adjustment for the potential confounders, compared with the reference group (bedtime ≤22:00), the odds ratios (95% confidence intervals) of NAFLD were 1.18 (1.05-1.32) and 1.42 (1.21-1.68) for bedtime from 22:00 to 24:00 and ≥24:00, respectively.
Conclusion
Late bedtime was slightly but significantly associated with an increased prevalence of newly diagnosed NAFLD, independently of confounding factors. It is suggested that early bedtime may be beneficial in preventing NAFLD.
CONFLICT OF INTEREST
The authors do not have any disclosures to report.
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