Albendazole and Clorsulon in Fasciola hepatica Control: Integrated Pharmacokinetic and Flukicidal Eficacy Assessment in Sheep
V. Chiappetta
Laboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Facultad de Ciencias Veterinarias, Tandil, Buenos Aires, Argentina
Search for more papers by this authorC. Cantón
Laboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Facultad de Ciencias Veterinarias, Tandil, Buenos Aires, Argentina
Search for more papers by this authorC. Pruzzo
Centro de Diagnóstico Veterinario (CEDIVE), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Chascomús, Buenos Aires, Argentina
Search for more papers by this authorC. Lanusse
Laboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Facultad de Ciencias Veterinarias, Tandil, Buenos Aires, Argentina
Search for more papers by this authorL. Alvarez
Laboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Facultad de Ciencias Veterinarias, Tandil, Buenos Aires, Argentina
Search for more papers by this authorCorresponding Author
L. Ceballos
Laboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Facultad de Ciencias Veterinarias, Tandil, Buenos Aires, Argentina
Correspondence:
L. Ceballos ([email protected])
Search for more papers by this authorV. Chiappetta
Laboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Facultad de Ciencias Veterinarias, Tandil, Buenos Aires, Argentina
Search for more papers by this authorC. Cantón
Laboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Facultad de Ciencias Veterinarias, Tandil, Buenos Aires, Argentina
Search for more papers by this authorC. Pruzzo
Centro de Diagnóstico Veterinario (CEDIVE), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Chascomús, Buenos Aires, Argentina
Search for more papers by this authorC. Lanusse
Laboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Facultad de Ciencias Veterinarias, Tandil, Buenos Aires, Argentina
Search for more papers by this authorL. Alvarez
Laboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Facultad de Ciencias Veterinarias, Tandil, Buenos Aires, Argentina
Search for more papers by this authorCorresponding Author
L. Ceballos
Laboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Facultad de Ciencias Veterinarias, Tandil, Buenos Aires, Argentina
Correspondence:
L. Ceballos ([email protected])
Search for more papers by this authorFunding: This work was supported by the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), and the Agencia Nacional de promoción Científica y Tecnológica, Argentina. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
ABSTRACT
Fasciola hepatica causes fasciolosis, a growing zoonotic disease that affects both livestock and humans worldwide. The main strategy to control fasciolosis in livestock animals, is based on drugs such as triclabendazole (TCBZ), albendazole (ABZ), clorsulon (CLOR), nitroxynil, closantel, and rafoxanide. Only TCBZ is available for F. hepatica control in human medicine and its resistance is growing. The use of drug combinations has been proposed as a strategy to delay it. This study compares the pharmacokinetics and flukicidal efficacy of ABZ + CLOR when administered together or separately in sheep infected with F. hepatica. Enhanced systemic exposure of the ABZ sulphoxide metabolite was observed after the co-administration ABZ + CLOR compared to the ABZ alone treatment. The CLOR disposition kinetics was not affected by its co-administration with ABZ. The flukicidal clinical efficacy was 85% (ABZ), 92% (CLOR) and 100% (ABZ + CLOR), respectively. The work described here contributes to the characterization of the disposition kinetics of both flukicidal molecules showing that the combined ABZ and CLOR therapy may enhance the efficacy against F. hepatica in sheep.
Conflicts of Interest
The authors declare no conflicts of interest.
Open Research
Data Availability Statement
The datasets generated and analyzed during the current study are available from the corresponding author upon reasonable request.
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