Regional Cerebral Gray Matter Volume in HIV-Positive Patients with Executive Function Deficits
Corresponding Author
Diogo Goulart Corrêa
Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil
Clínica de Diagnóstico por Imagem (CDPI), Avenida das Américas, 4666, 302A, 303, 307, 325, 326, Barra da Tijuca, Rio de Janeiro, RJ, Brazil
Correspondence: Address correspondence to Diogo Goulart Corrêa, Hospital Universitário Clementino Fraga Filho, Rua Rodolpho Paulo Rocco 255, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ 21941913, Brazil. E-mail: [email protected].Search for more papers by this authorNicolle Zimmermann
Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil
Department of Psychology, Pontifical Catholic University of Rio Grande do Sul, Avenida Ipiranga, 6681, Partenon, Porto Alegre, RS, Brazil
Search for more papers by this authorTania Maria Netto
Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil
Search for more papers by this authorGustavo Tukamoto
Clínica de Diagnóstico por Imagem (CDPI), Avenida das Américas, 4666, 302A, 303, 307, 325, 326, Barra da Tijuca, Rio de Janeiro, RJ, Brazil
Search for more papers by this authorNina Ventura
Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil
Clínica de Diagnóstico por Imagem (CDPI), Avenida das Américas, 4666, 302A, 303, 307, 325, 326, Barra da Tijuca, Rio de Janeiro, RJ, Brazil
Search for more papers by this authorSarah de Castro Bellini Leite
Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil
Search for more papers by this authorRafael Ferracini Cabral
Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil
Clínica de Diagnóstico por Imagem (CDPI), Avenida das Américas, 4666, 302A, 303, 307, 325, 326, Barra da Tijuca, Rio de Janeiro, RJ, Brazil
Search for more papers by this authorRochele Paz Fonseca
Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil
Department of Psychology, Pontifical Catholic University of Rio Grande do Sul, Avenida Ipiranga, 6681, Partenon, Porto Alegre, RS, Brazil
Search for more papers by this authorPaulo Roberto Valle Bahia
Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil
Search for more papers by this authorEmerson Leandro Gasparetto
Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil
Clínica de Diagnóstico por Imagem (CDPI), Avenida das Américas, 4666, 302A, 303, 307, 325, 326, Barra da Tijuca, Rio de Janeiro, RJ, Brazil
Search for more papers by this authorCorresponding Author
Diogo Goulart Corrêa
Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil
Clínica de Diagnóstico por Imagem (CDPI), Avenida das Américas, 4666, 302A, 303, 307, 325, 326, Barra da Tijuca, Rio de Janeiro, RJ, Brazil
Correspondence: Address correspondence to Diogo Goulart Corrêa, Hospital Universitário Clementino Fraga Filho, Rua Rodolpho Paulo Rocco 255, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ 21941913, Brazil. E-mail: [email protected].Search for more papers by this authorNicolle Zimmermann
Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil
Department of Psychology, Pontifical Catholic University of Rio Grande do Sul, Avenida Ipiranga, 6681, Partenon, Porto Alegre, RS, Brazil
Search for more papers by this authorTania Maria Netto
Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil
Search for more papers by this authorGustavo Tukamoto
Clínica de Diagnóstico por Imagem (CDPI), Avenida das Américas, 4666, 302A, 303, 307, 325, 326, Barra da Tijuca, Rio de Janeiro, RJ, Brazil
Search for more papers by this authorNina Ventura
Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil
Clínica de Diagnóstico por Imagem (CDPI), Avenida das Américas, 4666, 302A, 303, 307, 325, 326, Barra da Tijuca, Rio de Janeiro, RJ, Brazil
Search for more papers by this authorSarah de Castro Bellini Leite
Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil
Search for more papers by this authorRafael Ferracini Cabral
Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil
Clínica de Diagnóstico por Imagem (CDPI), Avenida das Américas, 4666, 302A, 303, 307, 325, 326, Barra da Tijuca, Rio de Janeiro, RJ, Brazil
Search for more papers by this authorRochele Paz Fonseca
Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil
Department of Psychology, Pontifical Catholic University of Rio Grande do Sul, Avenida Ipiranga, 6681, Partenon, Porto Alegre, RS, Brazil
Search for more papers by this authorPaulo Roberto Valle Bahia
Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil
Search for more papers by this authorEmerson Leandro Gasparetto
Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil
Clínica de Diagnóstico por Imagem (CDPI), Avenida das Américas, 4666, 302A, 303, 307, 325, 326, Barra da Tijuca, Rio de Janeiro, RJ, Brazil
Search for more papers by this authorConflicts of Interest: There is no conflict of interest to declare.
ABSTRACT
PURPOSE
To evaluate whether human immunodeficiency virus (HIV)-positive patients with and without executive functions deficits and healthy control subjects differ on cortical thickness and subcortical brain structures volume in vivo.
METHODS
In total, 34 HIV-positive patients with executive functions deficits were compared with 13 HIV-positive patients without executive functions deficits and 19 gender-, age-, and education-matched control subjects. Executive functions impairments were classified by performance on the Wisconsin card sorting test. T1 3-dimensional magnetization prepared rapid gradient echo-weighted imaging was performed using a 1.5 Tesla (magnetic resonance) MR scanner. FreeSurfer software was used to perform cortical reconstruction and volumetric segmentation of subcortical gray matter structures.
RESULTS
HIV-positive patients with executive functions deficits had smaller volumes in the right and left caudate compared with the HIV-positive patients without executive functions deficits and control groups. In addition, HIV-positive patients with executive functions deficits had smaller volumes in their left accumbens, right putamen, and globus pallidum compared with the control group. No significant differences in cortical thickness were observed between the groups.
CONCLUSION
HIV-positive patients with executive functions deficits have reduced volumes of several subcortical structures, primarily in the caudate nucleus.
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