Variations of ITSS-Morphology and their Relationship to Location and Tumor Volume in Patients with Glioblastoma
Corresponding Author
Delia Fahrendorf
Department of Clinical Radiology, University Hospital Münster, Münster, Germany
Correspondence: Address correspondence to Delia Fahrendorf, Department of Clinical Radiology, University Hospital Münster, Münster, Germany. E-mail: [email protected].Search for more papers by this authorVolker Hesselmann
Department of Neuroradiology, Asklepios Clinic Nord—Heidberg, Hamburg, Germany
Search for more papers by this authorWolfram Schwindt
Department of Clinical Radiology, University Hospital Münster, Münster, Germany
Search for more papers by this authorJohannes Wölfer
Department of Neurosurgery, University Hospital Münster, Münster, Germany
Search for more papers by this authorAstrid Jeibmann
Institute of Neuropathology, University Hospital Münster, Münster, Germany
Search for more papers by this authorHendrik Kooijman
Department of Clinical Radiology, University Hospital Münster, Münster, Germany
Search for more papers by this authorHarald Kugel
Philips Healthcare, Clinical Application, Lübeckertordamm, Hamburg, Germany
Search for more papers by this authorWalter Heindel
Department of Clinical Radiology, University Hospital Münster, Münster, Germany
Search for more papers by this authorAndrea Bink
Department of Radiology, Division of Diagnostic and Interventional Neuroradiology, University Hospital Basel
Search for more papers by this authorCorresponding Author
Delia Fahrendorf
Department of Clinical Radiology, University Hospital Münster, Münster, Germany
Correspondence: Address correspondence to Delia Fahrendorf, Department of Clinical Radiology, University Hospital Münster, Münster, Germany. E-mail: [email protected].Search for more papers by this authorVolker Hesselmann
Department of Neuroradiology, Asklepios Clinic Nord—Heidberg, Hamburg, Germany
Search for more papers by this authorWolfram Schwindt
Department of Clinical Radiology, University Hospital Münster, Münster, Germany
Search for more papers by this authorJohannes Wölfer
Department of Neurosurgery, University Hospital Münster, Münster, Germany
Search for more papers by this authorAstrid Jeibmann
Institute of Neuropathology, University Hospital Münster, Münster, Germany
Search for more papers by this authorHendrik Kooijman
Department of Clinical Radiology, University Hospital Münster, Münster, Germany
Search for more papers by this authorHarald Kugel
Philips Healthcare, Clinical Application, Lübeckertordamm, Hamburg, Germany
Search for more papers by this authorWalter Heindel
Department of Clinical Radiology, University Hospital Münster, Münster, Germany
Search for more papers by this authorAndrea Bink
Department of Radiology, Division of Diagnostic and Interventional Neuroradiology, University Hospital Basel
Search for more papers by this authorConflict of interest: We declare that we have no conflict of interest.
ABSTRACT
BACKGROUND
Susceptibility weighted imaging and assessment of intratumoral susceptibility signal (ITSS) morphology is used to identify high-grade glioma (HGG) in patients with suspected brain neoplasm.
PURPOSE
The aim of this study was to outline variations in ITSS-morphology and their relationship to location as well as volume of the lesion in patients with glioblastoma (GB).
MATERIALS AND METHODS
Contrast-enhanced SWI (CE-SWI) images of 40 patients with histologically confirmed GB were analyzed retrospectively with particular attention to ITSS-morphology dividing all lesions into two groups. Considering the location of the lesion within brain parenchyma, lesions with and without involvement of the subventricular zone (SVZ+/SVZ−) were discerned. Additionally, the contrast-enhancing tumor volume was evaluated. Statistical analysis was based on a classification analysis resulting in a classification rule (tree) as well as Mann-Whitney-U test.
RESULTS
The distribution of ITSS-scores showed differences between the SVZ+ and SVZ− groups. While SVZ-GB showed only fine-linear or dot-like ITSS, in SVZ+ GB the ITSS-morphology changed with the tumor volume, that is, in larger tumors dense and conglomerated ITSS were the predominant finding.
CONCLUSION
Our findings indicate that ITSS-morphology is not a random phenomenon. Location of GB, as well as tumor volume, appear to be factors contributing to ITSS morphology.
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