Skeletal Muscle Ventricles: A Promising Treatment Option for Heart Failure
Alberto Pochettino M.D.
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine Detroit, Michigan
Search for more papers by this authorDavid R. Anderson M.A.
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine Detroit, Michigan
Search for more papers by this authorRobert L. Hammond B.A.
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine Detroit, Michigan
Search for more papers by this authorAli D. Spanta M.D.
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine Detroit, Michigan
Search for more papers by this authorElke Hohenhaus M.D.
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine Detroit, Michigan
Search for more papers by this authorHiroshi Niinami M.D.
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine Detroit, Michigan
Search for more papers by this authorLu Huiping M.D.
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine Detroit, Michigan
Search for more papers by this authorRenato Ruggiero M.D.
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine Detroit, Michigan
Search for more papers by this authorTimothy L. Hooper M.B.
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine Detroit, Michigan
Search for more papers by this authorMenno Baars M.D.
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine Detroit, Michigan
Search for more papers by this authorChandan Devireddy
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine Detroit, Michigan
Search for more papers by this authorLarry W. Stephenson M.D.
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine Detroit, Michigan
Search for more papers by this authorAlberto Pochettino M.D.
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine Detroit, Michigan
Search for more papers by this authorDavid R. Anderson M.A.
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine Detroit, Michigan
Search for more papers by this authorRobert L. Hammond B.A.
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine Detroit, Michigan
Search for more papers by this authorAli D. Spanta M.D.
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine Detroit, Michigan
Search for more papers by this authorElke Hohenhaus M.D.
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine Detroit, Michigan
Search for more papers by this authorHiroshi Niinami M.D.
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine Detroit, Michigan
Search for more papers by this authorLu Huiping M.D.
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine Detroit, Michigan
Search for more papers by this authorRenato Ruggiero M.D.
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine Detroit, Michigan
Search for more papers by this authorTimothy L. Hooper M.B.
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine Detroit, Michigan
Search for more papers by this authorMenno Baars M.D.
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine Detroit, Michigan
Search for more papers by this authorChandan Devireddy
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine Detroit, Michigan
Search for more papers by this authorLarry W. Stephenson M.D.
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine Detroit, Michigan
Search for more papers by this authorAbstract
Our most recent work on cardiac assist with canine latissimus dorsi muscle in a skeletal muscle ventricle (SMV) configuration is reported here. One animal's SMV has been pumping blood effectively in the circulation for more than 16 months. To date there is no evidence of thromboembolism, and the dog has suffered no untoward effects. It has recently been shown, in a mock circulation study, that canine SMVs are capable of developing stroke work, at physiological preloads, much greater than that of the right ventricle and equivalent to that of the left ventricle. The improved ability of conditioned SMVs to perform work, independent of the circulation, during severe hypotension is also demonstrated. In the face of a 75% drop in left ventricular stroke work, the SMV stroke work dropped by only 50%. The continuing work on this subject suggests that a skeletal muscle ventricle may have the potential of becoming a viable alternative in the treatment of heart failure.
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