ORIGINAL ARTICLE
Effect of Rhus coriaria L. methanolic fruit extract on wound healing in diabetic and non-diabetic rats
Ahmad Za’al Alsarayreh PhD,
Sawsan Atallah Oran PhD,
Jumah Mutie Shakhanbeh PhD,
Corresponding Author
Ahmad Za’al Alsarayreh PhD
Department of Biological Sciences, Faculty of Sciences, University of Jordan, Amman, Jordan
Department of Biological Sciences, Mutah University, Karak, Jordan
Correspondence
Ahmad Za’al Alsarayreh, Department of Biological Sciences, Faculty of Sciences, University of Jordan, Amman, Jordan.
Email: [email protected]
Search for more papers by this authorSawsan Atallah Oran PhD
Department of Biological Sciences, Faculty of Sciences, University of Jordan, Amman, Jordan
Search for more papers by this authorJumah Mutie Shakhanbeh PhD
Department of Biological Sciences, Mutah University, Karak, Jordan
Search for more papers by this authorAhmad Za’al Alsarayreh PhD,
Sawsan Atallah Oran PhD,
Jumah Mutie Shakhanbeh PhD,
Corresponding Author
Ahmad Za’al Alsarayreh PhD
Department of Biological Sciences, Faculty of Sciences, University of Jordan, Amman, Jordan
Department of Biological Sciences, Mutah University, Karak, Jordan
Correspondence
Ahmad Za’al Alsarayreh, Department of Biological Sciences, Faculty of Sciences, University of Jordan, Amman, Jordan.
Email: [email protected]
Search for more papers by this authorSawsan Atallah Oran PhD
Department of Biological Sciences, Faculty of Sciences, University of Jordan, Amman, Jordan
Search for more papers by this authorJumah Mutie Shakhanbeh PhD
Department of Biological Sciences, Mutah University, Karak, Jordan
Search for more papers by this authorAbstract
Aim
This study assessed the effects of topical application of R. coriaria extract on the rate of wound closure. The rate of wound contraction was used to assess the wound healing efficacy of the R. coriaria fruit methanolic extract.
Methods
Using excision and burn model of wound repair in diabetic male Wistar rats. Also, hydroxyproline, collagen content, and proinflammatory and anti-inflammatory cytokines levels were determined in this study.
Results
During the early wound healing phase, interleukin 6 (IL-6) levels were found to be decreased by R. coriaria treatment and increased the level of interleukin 10 (IL-10). Increased wound contraction augmented with hydroxyproline and collagen content, supporting the early wound healing exhibited by R. coriaria. The epithelialization, neovascularization and enhanced hydroxyproline and collagen expression were strongly associated with the healing pattern.
Conclusion
This study indicating that R. coriaria methanolic fruit extract has a potent wound healing capacity. And may be effective in the topical therapy of wound healing.
CONFLICT OF INTEREST
The authors declare no conflict of interest.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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