CASE REPORT
A first case of hepatocellular carcinoma in the baboon (Papio spp.) placenta
Natalia Schlabritz-Loutsevitch,
Maira Carrillo,
Cun Li,
Peter Nathanielsz,
Christopher Maguire,
James Maher,
Edward Dick Jr,
Gene Hubbard,
Jerzy Stanek,
Corresponding Author
Natalia Schlabritz-Loutsevitch
Texas Tech University Health Sciences Center at the Permian Basin, Odessa, Texas
Correspondence
Natalia Schlabritz-Lutsevich, Texas Tech University Health Sciences Center at the Permian Basin, Odessa, TX.
Email: [email protected]
Search for more papers by this authorMaira Carrillo
Texas Tech University Health Sciences Center at the Permian Basin, Odessa, Texas
Search for more papers by this authorCun Li
University of Wyoming, Laramie, Wyoming
Texas Biomedical Research Institute, San Antonio, Texas
Search for more papers by this authorPeter Nathanielsz
University of Wyoming, Laramie, Wyoming
Texas Biomedical Research Institute, San Antonio, Texas
Search for more papers by this authorChristopher Maguire
Texas Tech University Health Sciences Center at the Permian Basin, Odessa, Texas
Search for more papers by this authorJames Maher
Texas Tech University Health Sciences Center at the Permian Basin, Odessa, Texas
Search for more papers by this authorEdward Dick Jr
Texas Biomedical Research Institute, San Antonio, Texas
Search for more papers by this authorGene Hubbard
University of Texas Health Sciences Center at San Antonio, San Antonio, Texas
Search for more papers by this authorNatalia Schlabritz-Loutsevitch,
Maira Carrillo,
Cun Li,
Peter Nathanielsz,
Christopher Maguire,
James Maher,
Edward Dick Jr,
Gene Hubbard,
Jerzy Stanek,
Corresponding Author
Natalia Schlabritz-Loutsevitch
Texas Tech University Health Sciences Center at the Permian Basin, Odessa, Texas
Correspondence
Natalia Schlabritz-Lutsevich, Texas Tech University Health Sciences Center at the Permian Basin, Odessa, TX.
Email: [email protected]
Search for more papers by this authorMaira Carrillo
Texas Tech University Health Sciences Center at the Permian Basin, Odessa, Texas
Search for more papers by this authorCun Li
University of Wyoming, Laramie, Wyoming
Texas Biomedical Research Institute, San Antonio, Texas
Search for more papers by this authorPeter Nathanielsz
University of Wyoming, Laramie, Wyoming
Texas Biomedical Research Institute, San Antonio, Texas
Search for more papers by this authorChristopher Maguire
Texas Tech University Health Sciences Center at the Permian Basin, Odessa, Texas
Search for more papers by this authorJames Maher
Texas Tech University Health Sciences Center at the Permian Basin, Odessa, Texas
Search for more papers by this authorEdward Dick Jr
Texas Biomedical Research Institute, San Antonio, Texas
Search for more papers by this authorGene Hubbard
University of Texas Health Sciences Center at San Antonio, San Antonio, Texas
Search for more papers by this authorFirst published: 24 September 2018
Abstract
We present a case of hepatocellular carcinoma (HCC) in the placenta of healthy baboon (Papio spp.). Grossly, the fetal, maternal, and placental tissues were unremarkable. Histologically, the placenta contained an unencapsulated, poorly demarcated, infiltrative, solidly cellular neoplasm composed of cells that resembled hepatocytes. The neoplastic cells were diffusely positive for vimentin and focally positive for Ae1/Ae3, Arginase -1, glutamine synthetase, and CD10, and negative for ER, vascular markers (CD31 and D240), S100, glypican, C-reactive protein, FABP, desmin, and beta-catenin; INI1 positivity was similar to non-neoplastic tissues. The case likely represents a unique subtype of HCC.
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