Volume 43, Issue 4 pp. 288-291
Short Paper

Large-scale pedigree analysis leads to evidence for founder effects of hypertrophic cardiomyopathy in rhesus macaques (Macaca mulatta)

Sree Kanthaswamy

Corresponding Author

Sree Kanthaswamy

Department of Anthropology, University of California, Davis, CA, USA

California National Primate Research Center, University of California, Davis, CA, USA

Department of Environmental Toxicology, University of California, Davis, CA, USA

Correspondence

Dr. Sree Kanthaswamy, Department of Anthropology, University of California, One Shields Avenue, Davis, CA 95616, USA.

Tel.: (530) 752 1588;

fax: (530) 752 8885;

e-mail: [email protected]

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Rachel Reader

Rachel Reader

California National Primate Research Center, University of California, Davis, CA, USA

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Ross Tarara

Ross Tarara

California National Primate Research Center, University of California, Davis, CA, USA

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Karen Oslund

Karen Oslund

California National Primate Research Center, University of California, Davis, CA, USA

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Mark Allen

Mark Allen

California National Primate Research Center, University of California, Davis, CA, USA

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Jillian Ng

Jillian Ng

California National Primate Research Center, University of California, Davis, CA, USA

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Chloe Grinberg

Chloe Grinberg

California National Primate Research Center, University of California, Davis, CA, USA

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Dallas Hyde

Dallas Hyde

California National Primate Research Center, University of California, Davis, CA, USA

School of Veterinary Medicine, University of California, Davis, CA, USA

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David G. Smith

David G. Smith

Department of Anthropology, University of California, Davis, CA, USA

California National Primate Research Center, University of California, Davis, CA, USA

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Nicholas Lerche

Nicholas Lerche

California National Primate Research Center, University of California, Davis, CA, USA

School of Veterinary Medicine, University of California, Davis, CA, USA

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First published: 09 May 2014
Citations: 13

Abstract

Background

Hypertrophic cardiomyopathy (HCM) is the abnormal thickening of the ventricles and an increase in cardiac mass.

Methods

Pedigree analyses involving 108 rhesus macaques with pronounced HCM were performed.

Results

Analyses revealed a strong genetic predisposition to this disease.

Conclusions

Macaques are ideal for investigating HCM because of their marked similarity to humans genetically, physiologically, and anatomically.

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