Long-term risk of end-stage renal diseases with maintenance dialysis among chronic hepatitis C patients after antiviral therapy in Taiwan
Meng-Hsuan Hsieh
Health Management Center, Department of Occupational and Environmental Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
School of Medicine and Hepatitis Research Center, College of Medicine, and Center for Cancer Research and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan
Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan
Search for more papers by this authorMing-Jong Bair
Division of Gastroenterology, Department of Internal Medicine, Taitung Mackay Memorial Hospital, Taitung, Taiwan
Search for more papers by this authorPei-Chien Tsai
Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Search for more papers by this authorKuo-Chih Tseng
Department of Gastroenterology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chia-Yi, Taiwan
Search for more papers by this authorChing-Chu Lo
Department of Internal Medicine, St. Martin De Porres Hospital - Daya, Chiayi, Taiwan
Search for more papers by this authorChi-Yi Chen
Department of Internal Medicine, Chiayi Christian Hospital, Chiayi, Taiwan
Search for more papers by this authorHsing-Tao Kuo
Division of Hepatogastroenterology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan
Search for more papers by this authorChao-Hung Hung
Division of Hepatogastroenterology, Department of Internal Medicine, ChiaYi Chang Gung Memorial Hospital, Chiayi, Taiwan
Search for more papers by this authorHsueh-Chou Lai
Division of Hepatogastroenterology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan
Search for more papers by this authorCheng-Yuan Peng
Division of Hepatogastroenterology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan
Search for more papers by this authorJing-Houng Wang
Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
Search for more papers by this authorJyh-Jou Chen
Division of Gastroenterology and Hepatology, Chi-Mei Medical Center, Liouying, Tainan, Taiwan
Search for more papers by this authorPei-Lun Lee
Division of Gastroenterology and Hepatology, Chi-Mei Medical Center, Liouying, Tainan, Taiwan
Search for more papers by this authorRong-Nan Chien
Division of Hepatology, Department of Gastroenterology and Hepatology, Linkou Medical Center, Chang Gung Memorial Hospital, Keelung, Taiwan
Search for more papers by this authorChi-Chieh Yang
Division of Gastroenterology, Department of Internal Medicine, Show Chwan Memorial Hospital, Changhua, Taiwan
Search for more papers by this authorGin-Ho Lo
Division of Gastroenterology and Hepatology, Department of Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan, School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan
Search for more papers by this authorJia-Horng Kao
Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
Division of Gastroenterology and Hepatology, National Taiwan University Hospital, Taipei, Taiwan
Search for more papers by this authorChun-Jen Liu
Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
Division of Gastroenterology and Hepatology, National Taiwan University Hospital, Taipei, Taiwan
Search for more papers by this authorChen-Hua Liu
Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
Division of Gastroenterology and Hepatology, National Taiwan University Hospital, Taipei, Taiwan
Search for more papers by this authorSheng-Lei Yan
Division of Gastroenterology, Department of Internal Medicine, Chang Bing Show-Chwan Memorial Hospital, Changhua, Taiwan
Search for more papers by this authorChun-Yen Lin
Division of Hepatology, Department of Gastroenterology and Hepatology, Linkou Medical Center, Chang Gung Memorial Hospital, Keelung, Taiwan
Search for more papers by this authorWei-Wen Su
Division of Gastroenterology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan
Search for more papers by this authorCheng-Hsin Chu
Division of Gastroenterology, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan
Search for more papers by this authorChih-Jen Chen
Division of Gastroenterology, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan
Search for more papers by this authorShui-Yi Tung
Division of Hepatogastroenterology, Department of Internal Medicine, ChiaYi Chang Gung Memorial Hospital, Chiayi, Taiwan
Search for more papers by this authorChi-Ming Tai
Division of Gastroenterology and Hepatology, Department of Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan, School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan
Search for more papers by this authorChih-Wen Lin
Division of Gastroenterology and Hepatology, Department of Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan, School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan
Search for more papers by this authorPin-Nan Cheng
Division of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan
Search for more papers by this authorYen-Cheng Chiu
Division of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan
Search for more papers by this authorChia-Chi Wang
Division of Gastroenterology, Department of Internal Medicine, Taipei Tzuchi Hospital, The Buddhist Tzuchi Medical Foundation, New Taipei City, School of Medicine, Tzu Chi University, Hualien, Taiwan
Search for more papers by this authorJin-Shiung Cheng
Division of Gastroenterology and Hepatology, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
Search for more papers by this authorWei-Lun Tsai
Division of Gastroenterology and Hepatology, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
Search for more papers by this authorHan-Chieh Lin
Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
Search for more papers by this authorYi-Hsiang Huang
Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
Search for more papers by this authorMing-Lun Yeh
Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
School of Medicine and Hepatitis Research Center, College of Medicine, and Center for Cancer Research and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan
Search for more papers by this authorChung-Feng Huang
Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
School of Medicine and Hepatitis Research Center, College of Medicine, and Center for Cancer Research and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan
Search for more papers by this authorJee-Fu Huang
Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
School of Medicine and Hepatitis Research Center, College of Medicine, and Center for Cancer Research and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan
Search for more papers by this authorChia-Yen Dai
Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
School of Medicine and Hepatitis Research Center, College of Medicine, and Center for Cancer Research and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan
Search for more papers by this authorCorresponding Author
Ming-Lung Yu
Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
School of Medicine and Hepatitis Research Center, College of Medicine, and Center for Cancer Research and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan
Correspondence
Ming-Lung Yu and Wan-Long Chuang, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, Kaohsiung 807, Taiwan.
Email: [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Wan-Long Chuang
Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
School of Medicine and Hepatitis Research Center, College of Medicine, and Center for Cancer Research and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan
Correspondence
Ming-Lung Yu and Wan-Long Chuang, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, Kaohsiung 807, Taiwan.
Email: [email protected]; [email protected]
Search for more papers by this authorT-COACH investigators
Search for more papers by this authorMeng-Hsuan Hsieh
Health Management Center, Department of Occupational and Environmental Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
School of Medicine and Hepatitis Research Center, College of Medicine, and Center for Cancer Research and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan
Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan
Search for more papers by this authorMing-Jong Bair
Division of Gastroenterology, Department of Internal Medicine, Taitung Mackay Memorial Hospital, Taitung, Taiwan
Search for more papers by this authorPei-Chien Tsai
Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Search for more papers by this authorKuo-Chih Tseng
Department of Gastroenterology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chia-Yi, Taiwan
Search for more papers by this authorChing-Chu Lo
Department of Internal Medicine, St. Martin De Porres Hospital - Daya, Chiayi, Taiwan
Search for more papers by this authorChi-Yi Chen
Department of Internal Medicine, Chiayi Christian Hospital, Chiayi, Taiwan
Search for more papers by this authorHsing-Tao Kuo
Division of Hepatogastroenterology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan
Search for more papers by this authorChao-Hung Hung
Division of Hepatogastroenterology, Department of Internal Medicine, ChiaYi Chang Gung Memorial Hospital, Chiayi, Taiwan
Search for more papers by this authorHsueh-Chou Lai
Division of Hepatogastroenterology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan
Search for more papers by this authorCheng-Yuan Peng
Division of Hepatogastroenterology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan
Search for more papers by this authorJing-Houng Wang
Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
Search for more papers by this authorJyh-Jou Chen
Division of Gastroenterology and Hepatology, Chi-Mei Medical Center, Liouying, Tainan, Taiwan
Search for more papers by this authorPei-Lun Lee
Division of Gastroenterology and Hepatology, Chi-Mei Medical Center, Liouying, Tainan, Taiwan
Search for more papers by this authorRong-Nan Chien
Division of Hepatology, Department of Gastroenterology and Hepatology, Linkou Medical Center, Chang Gung Memorial Hospital, Keelung, Taiwan
Search for more papers by this authorChi-Chieh Yang
Division of Gastroenterology, Department of Internal Medicine, Show Chwan Memorial Hospital, Changhua, Taiwan
Search for more papers by this authorGin-Ho Lo
Division of Gastroenterology and Hepatology, Department of Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan, School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan
Search for more papers by this authorJia-Horng Kao
Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
Division of Gastroenterology and Hepatology, National Taiwan University Hospital, Taipei, Taiwan
Search for more papers by this authorChun-Jen Liu
Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
Division of Gastroenterology and Hepatology, National Taiwan University Hospital, Taipei, Taiwan
Search for more papers by this authorChen-Hua Liu
Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
Division of Gastroenterology and Hepatology, National Taiwan University Hospital, Taipei, Taiwan
Search for more papers by this authorSheng-Lei Yan
Division of Gastroenterology, Department of Internal Medicine, Chang Bing Show-Chwan Memorial Hospital, Changhua, Taiwan
Search for more papers by this authorChun-Yen Lin
Division of Hepatology, Department of Gastroenterology and Hepatology, Linkou Medical Center, Chang Gung Memorial Hospital, Keelung, Taiwan
Search for more papers by this authorWei-Wen Su
Division of Gastroenterology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan
Search for more papers by this authorCheng-Hsin Chu
Division of Gastroenterology, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan
Search for more papers by this authorChih-Jen Chen
Division of Gastroenterology, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan
Search for more papers by this authorShui-Yi Tung
Division of Hepatogastroenterology, Department of Internal Medicine, ChiaYi Chang Gung Memorial Hospital, Chiayi, Taiwan
Search for more papers by this authorChi-Ming Tai
Division of Gastroenterology and Hepatology, Department of Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan, School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan
Search for more papers by this authorChih-Wen Lin
Division of Gastroenterology and Hepatology, Department of Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan, School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan
Search for more papers by this authorPin-Nan Cheng
Division of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan
Search for more papers by this authorYen-Cheng Chiu
Division of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan
Search for more papers by this authorChia-Chi Wang
Division of Gastroenterology, Department of Internal Medicine, Taipei Tzuchi Hospital, The Buddhist Tzuchi Medical Foundation, New Taipei City, School of Medicine, Tzu Chi University, Hualien, Taiwan
Search for more papers by this authorJin-Shiung Cheng
Division of Gastroenterology and Hepatology, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
Search for more papers by this authorWei-Lun Tsai
Division of Gastroenterology and Hepatology, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
Search for more papers by this authorHan-Chieh Lin
Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
Search for more papers by this authorYi-Hsiang Huang
Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
Search for more papers by this authorMing-Lun Yeh
Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
School of Medicine and Hepatitis Research Center, College of Medicine, and Center for Cancer Research and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan
Search for more papers by this authorChung-Feng Huang
Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
School of Medicine and Hepatitis Research Center, College of Medicine, and Center for Cancer Research and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan
Search for more papers by this authorJee-Fu Huang
Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
School of Medicine and Hepatitis Research Center, College of Medicine, and Center for Cancer Research and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan
Search for more papers by this authorChia-Yen Dai
Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
School of Medicine and Hepatitis Research Center, College of Medicine, and Center for Cancer Research and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan
Search for more papers by this authorCorresponding Author
Ming-Lung Yu
Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
School of Medicine and Hepatitis Research Center, College of Medicine, and Center for Cancer Research and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan
Correspondence
Ming-Lung Yu and Wan-Long Chuang, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, Kaohsiung 807, Taiwan.
Email: [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Wan-Long Chuang
Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
School of Medicine and Hepatitis Research Center, College of Medicine, and Center for Cancer Research and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan
Correspondence
Ming-Lung Yu and Wan-Long Chuang, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, Kaohsiung 807, Taiwan.
Email: [email protected]; [email protected]
Search for more papers by this authorT-COACH investigators
Search for more papers by this authorDeclaration of conflict of interest: There is no conflict of interest for this study.
Meng-Hsuan Hsieh and Ming-Jong Bair contributed equally to this work.
Abstract
Background and Aim
Chronic hepatitis C virus (HCV) infection is associated with impaired renal function. The aim of this study is to explore the risk of and factors associated with end-stage renal diseases (ESRD) under maintenance dialysis among HCV patients after anti-HCV therapy.
Methods
A total of 12 696 HCV-infected patients with interferon-based therapy, including 9679 (76.2%) achieving sustained virological response (SVR), were enrolled from 23 hospitals in Taiwan.
Results
During a mean follow-up period of 5.3 years (67 554 person-years), the annual incidence of 4.1/10 000 person-years, 4.0/10 000 and 4.7/10 000 person-years among SVR patients and non-SVR patients, respectively. History of diabetes and baseline estimated glomerular filtration rate < 60 mL/min/m2, instead of SVR, were the significant risk factors for developing ESRD with maintenance dialysis after anti-HCV therapy (adjusted hazard ratio 7.75 and 9.78).
Conclusion
Diabetes and baseline impaired renal function were strongly associated with progression to ESRD with maintenance dialysis among chronic HCV-infected patients after antiviral therapy.
Supporting Information
| Filename | Description |
|---|---|
| jgh15469-sup-0001-Figure_S1-S2.docxWord 2007 document , 126.6 KB |
Figure S1. The risk factors for ESRD considering death as competing risk in this study, analyzed after initial antiviral therapy (A) SVR vs. Non-SVR (p=0.179 by Gray's method; p=0.524 by crude cox regression; p=0.148 by adjusted cox regression). Figure S2. The short-term eGFR change on pre- on- and post-treatment on CHC patients with/without SVR (BL: baseline, week12: 12th week of the therapeutic course, EOT: end of treatment, EOF: 24th week after end of treatment). |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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