Journal of the European Academy of Dermatology and Venereology

Volume 32, Issue 9 pp. 1589-1596

Original Article

Risk of developing pressure sore in amyotrophic lateral sclerosis patients – a nationwide cohort study

J.-H. Chen,

J.-H. Chen

Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan

School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan

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S.-C. Wu,

S.-C. Wu

School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan

Trauma and Emergency Center, China Medical University Hospital, Taichung, Taiwan

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H.-J. Chen,

H.-J. Chen

Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan

College of Medicine, China Medical University, Taichung, Taiwan

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C.-H. Kao,

C.-H. Kao

School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan

Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan

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C.-H. Tseng,

Corresponding Author

C.-H. Tseng

[email protected]

School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan

Department of Neurology, China Medical University Hospital, Taichung, Taiwan

Correspondence: C.-H. Tseng. E-mail: [email protected]Search for more papers by this author

C.-H. Tsai,

C.-H. Tsai

School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan

Department of Neurology, China Medical University Hospital, Taichung, Taiwan

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J.-H. Chen,

J.-H. Chen

Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan

School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan

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S.-C. Wu,

S.-C. Wu

School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan

Trauma and Emergency Center, China Medical University Hospital, Taichung, Taiwan

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H.-J. Chen,

H.-J. Chen

Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan

College of Medicine, China Medical University, Taichung, Taiwan

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C.-H. Kao,

C.-H. Kao

School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan

Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan

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C.-H. Tseng,

Corresponding Author

C.-H. Tseng

[email protected]

School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan

Department of Neurology, China Medical University Hospital, Taichung, Taiwan

Correspondence: C.-H. Tseng. E-mail: [email protected]Search for more papers by this author

C.-H. Tsai,

C.-H. Tsai

School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan

Department of Neurology, China Medical University Hospital, Taichung, Taiwan

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First published: 06 March 2018

https://doi.org/10.1111/jdv.14911

Citations: 9

Conflicts of interest

The authors have no conflict of interest to declare.

Funding sources

This study is supported partly by Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence (MOHW104-TDU-B-212-113002), China Medical University Hospital, Academia Sinica Taiwan Biobank, Stroke Biosignature Project (BM104010092), NRPB Stroke Clinical Trial Consortium (MOST 103-2325-B-039-006) and CMU under the Aim for Top University Plan of the Ministry of Education, Taiwan.

Drs. J.-H. Chen and S.-C. Wu contributed equally to this work

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Abstract

Background

Prior investigations with few cases have disclosed lack of pressure sore (PrS) formation was characteristic in amyotrophic lateral sclerosis (ALS) patients. However, studies with larger samples are lacking to ascertain this concept.

Objective

To investigate whether patients with ALS have higher risk of PrS.

Methods

Utilizing a Taiwan National Insurance claims data set with 23 million participants, we extracted 514 patients with ALS and 2056 controls from 1 January 2000 to 31 December 2008. Both groups were followed up until PrS occurrence during study period (2000–2011). The PrS risk was calculated with Cox proportional regression model.

Results

The patients with ALS had a greater PrS risk (adjusted hazard ratio [aHR] = 8.82, 95% confidence interval [CI] = 4.90–15.9, P < 0.001) than the controls did. PrS risk was much higher in ALS women (aHR = 26.6, 95% CI = 9.05–78.2, P < 0.001) than in ALS men (aHR = 4.38, 95% CI = 1.99–9.68, P < 0.001). Besides, in people aged 20–54, ALS was linked with a much greater PrS risk (aHR = 27.7, 95% CI = 5.79–132, P < 0.001) than in those aged ≥55 (aHR = 6.10, 95% CI = 3.10–12.0, P < 0.001).

Conclusions

Amyotrophic lateral sclerosis is discovered to be correlated with an enhanced PrS risk. For PrS prevention, it is needed to pay more attention to the management of the patients with ALS, particularly in women and those with relatively younger age. Further investigations are needed to confirm the findings in this study.

Abstract

Linked article: This article is commented on by J. Dissemond, pp. 1406–1407 in this issue. To view this article https://doi.org/10.1111/jdv.15196

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Volume32, Issue9

September 2018

Pages 1589-1596

Risk of developing pressure sore in amyotrophic lateral sclerosis patients – a nationwide cohort study

Abstract

Background

Objective

Methods

Results

Conclusions

Abstract

References

Citing Literature

References

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Risk of developing pressure sore in amyotrophic lateral sclerosis patients – a nationwide cohort study

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Background

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