Trends in incidence and predictions of cutaneous melanoma across Europe up to 2015
M. Arnold
Department of Public Health, ErasmusMC University Medical Center Rotterdam, The Netherlands
Search for more papers by this authorC. Holterhues
Department of Dermatology, ErasmusMC University Medical Center Rotterdam, The Netherlands
Search for more papers by this authorL.M. Hollestein
Department of Dermatology, ErasmusMC University Medical Center Rotterdam, The Netherlands
Search for more papers by this authorJ.W.W. Coebergh
Department of Public Health, ErasmusMC University Medical Center Rotterdam, The Netherlands
Comprehensive Cancer Center South, Eindhoven, The Netherlands
Search for more papers by this authorT. Nijsten
Department of Dermatology, ErasmusMC University Medical Center Rotterdam, The Netherlands
Search for more papers by this authorE. Pukkala
Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland
School of Health Sciences, University of Tampere, Tampere, Finland
Search for more papers by this authorL. Tryggvadóttir
Icelandic Cancer Registry, Reykjavik, Iceland
Faculty of Medicine, University of Iceland, Reykjavik, Iceland
Search for more papers by this authorM.J. Bento
North Region Cancer Registry, Portuguese Oncology Institute, Porto, Portugal
Search for more papers by this authorCh.S. Diba
National Cancer Registry of Slovakia, National Health Information Center, Bratislava, Slovakia
Search for more papers by this authorR. Micallef
Department of Health Information and Research, Malta National Cancer Registry, Guardamangia, Malta
Search for more papers by this authorM. Primic-Žakelj
Epidemiology and Cancer Registry, Institute of Oncology Ljubljana, Zaloska, Ljubljana, Slovenia
Search for more papers by this authorM.I. Izarzugaza
Basque Goverment Health Department, Basque Cancer Registry, Vitoria-Gasteiz, Spain
Search for more papers by this authorJ. Perucha
Servicio de Epidemiología y Prevención Sanitaria, Registro de Cáncer de La Rioja, Logroño, Spain
Search for more papers by this authorR. Marcos-Gragera
Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Girona Biomedical Research Institute (IdiBGi), Girona, Spain
Search for more papers by this authorJ. Galceran
Tarragona Cancer Registry, Foundation Society for Cancer Research and Prevention, Pere Virgili Health Research Institute, Reus, Spain
Search for more papers by this authorE. Ardanaz
Navarra Cancer Registry, Navarra Public Health Institute, Pamplona, Spain
CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain
Search for more papers by this authorR. Schaffar
Geneva Cancer Registry, Institute for Social and Preventive Medicine, University of Geneva, Geneva, Switzerland
Search for more papers by this authorCorresponding Author
E. de Vries
Department of Public Health, ErasmusMC University Medical Center Rotterdam, The Netherlands
Department of Dermatology, ErasmusMC University Medical Center Rotterdam, The Netherlands
Comprehensive Cancer Center South, Eindhoven, The Netherlands
Correspondence: E. de Vries. E-mail: [email protected]Search for more papers by this authorM. Arnold
Department of Public Health, ErasmusMC University Medical Center Rotterdam, The Netherlands
Search for more papers by this authorC. Holterhues
Department of Dermatology, ErasmusMC University Medical Center Rotterdam, The Netherlands
Search for more papers by this authorL.M. Hollestein
Department of Dermatology, ErasmusMC University Medical Center Rotterdam, The Netherlands
Search for more papers by this authorJ.W.W. Coebergh
Department of Public Health, ErasmusMC University Medical Center Rotterdam, The Netherlands
Comprehensive Cancer Center South, Eindhoven, The Netherlands
Search for more papers by this authorT. Nijsten
Department of Dermatology, ErasmusMC University Medical Center Rotterdam, The Netherlands
Search for more papers by this authorE. Pukkala
Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland
School of Health Sciences, University of Tampere, Tampere, Finland
Search for more papers by this authorL. Tryggvadóttir
Icelandic Cancer Registry, Reykjavik, Iceland
Faculty of Medicine, University of Iceland, Reykjavik, Iceland
Search for more papers by this authorM.J. Bento
North Region Cancer Registry, Portuguese Oncology Institute, Porto, Portugal
Search for more papers by this authorCh.S. Diba
National Cancer Registry of Slovakia, National Health Information Center, Bratislava, Slovakia
Search for more papers by this authorR. Micallef
Department of Health Information and Research, Malta National Cancer Registry, Guardamangia, Malta
Search for more papers by this authorM. Primic-Žakelj
Epidemiology and Cancer Registry, Institute of Oncology Ljubljana, Zaloska, Ljubljana, Slovenia
Search for more papers by this authorM.I. Izarzugaza
Basque Goverment Health Department, Basque Cancer Registry, Vitoria-Gasteiz, Spain
Search for more papers by this authorJ. Perucha
Servicio de Epidemiología y Prevención Sanitaria, Registro de Cáncer de La Rioja, Logroño, Spain
Search for more papers by this authorR. Marcos-Gragera
Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Girona Biomedical Research Institute (IdiBGi), Girona, Spain
Search for more papers by this authorJ. Galceran
Tarragona Cancer Registry, Foundation Society for Cancer Research and Prevention, Pere Virgili Health Research Institute, Reus, Spain
Search for more papers by this authorE. Ardanaz
Navarra Cancer Registry, Navarra Public Health Institute, Pamplona, Spain
CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain
Search for more papers by this authorR. Schaffar
Geneva Cancer Registry, Institute for Social and Preventive Medicine, University of Geneva, Geneva, Switzerland
Search for more papers by this authorCorresponding Author
E. de Vries
Department of Public Health, ErasmusMC University Medical Center Rotterdam, The Netherlands
Department of Dermatology, ErasmusMC University Medical Center Rotterdam, The Netherlands
Comprehensive Cancer Center South, Eindhoven, The Netherlands
Correspondence: E. de Vries. E-mail: [email protected]Search for more papers by this authorConflicts of interest
None declared.Funding sources
This research was co-funded by the Bristol-Meyer Squibb (time of C. Holterhues) and the Departments of Dermatology and Public Health of the ErasmusMC University Medical Centre.Abstract
Background
Melanoma is a significant health problem in Caucasian populations. The most recently available data from cancer registries often have a delay of several months up to a few years and they are generally not easily accessible.
Objectives
To assess recent age- and sex-specific trends in melanoma incidence and make predictions for 2010 and 2015.
Methods
A retrospective registry-based analysis was performed with data from 29 European cancer registries. Most of them had data available from 1990 up to 2006/7. World-standardized incidence rates (WSR) and the estimated annual percentage change (EAPC) were computed. Predictions were based on linear projection models.
Results
Overall the incidence of melanoma is rapidly rising and will continue to do so. The incidence among women in Europe was generally higher than in men. The highest incidence rates were seen for Northern and north-western countries like the UK, Ireland and the Netherlands. The lowest incidence rates were observed in Portugal and Spain. The incidence overall remained stable in Norway, where, amongst young (25–49 years) Norwegian males rates significantly decreased (EAPC −2.8, 95% CI −3.6; −2.0). Despite a low melanoma incidence among persons above the age of 70, this age group experienced the greatest increase in risk during the study period.
Conclusions
Incidence rates of melanoma are expected to continue rising. These trends are worrying in terms of disease burden, particularly in eastern European countries.
References
- 1Miller AJ, Mihm MC. Jr. Melanoma.N Engl J Med 2006; 355: 51–65.
- 2Holterhues C, Vries E, Louwman MW, Koljenovic S, Nijsten T. Incidence and trends of cutaneous malignancies in The Netherlands, 1989-2005. J Invest Dermatol 2010; 130: 1807–1812.
- 3Karim-Kos HE, de Vries E, Soerjomataram I, Lemmens V, Siesling S, Coebergh JW. Recent trends of cancer in Europe: a combined approach of incidence, survival and mortality for 17 cancer sites since the 1990s. Eur J Cancer 2008; 44: 1345–1389.
- 4de Vries E, Bray FI, Coebergh JW, Parkin DM. Changing epidemiology of malignant cutaneous melanoma in Europe 1953–1997: rising trends in incidence and mortality but recent stabilizations in western Europe and decreases in Scandinavia. Int J Cancer 2003; 107: 119–126.
- 5Erdmann F, Lortet-Tieulent J, Schuz J et al. International trends in the incidence of malignant melanoma 1953-2008–are recent generations at higher or lower risk? Int J Cancer 2013; 132: 385–400.
- 6Forsea AM, Del Marmol V, de Vries E, Bailey EE, Geller AC. Melanoma incidence and mortality in Europe: new estimates, persistent disparities. Br J Dermatol 2012; 167: 1124–1130.
- 7Gandini S, Sera F, Cattaruzza MS et al. Meta-analysis of risk factors for cutaneous melanoma: III. Family history, actinic damage and phenotypic factors. Eur J Cancer 2005; 41: 2040–2059.
- 8Gandini S, Sera F, Cattaruzza MS et al. Meta-analysis of risk factors for cutaneous melanoma: II. Sun exposure. Eur J Cancer 2005; 41: 45–60.
- 9Gandini S, Sera F, Cattaruzza MS et al. Meta-analysis of risk factors for cutaneous melanoma: I Common and atypical naevi. Eur J Cancer 2005; 41: 28–44.
- 10Parkin DM, Muir CS. Cancer Incidence in Five Continents. Comparability and quality of data. IARC Sci Publ 1992; 120: 45–173.
- 11Parkin DM, Muir CS, Whelan JS, Gao YT, Ferlay J, Powelly. Cancer incidence in five continents. Vol. VI, IARC scientific publications, Lyon, France, 1992.
- 12Kim HJ, Fay MP, Feuer EJ, Midthune DN. Permutation tests for joinpoint regression with applications to cancer rates. Stat Med 2000; 19: 335–351.
10.1002/(SICI)1097-0258(20000215)19:3<335::AID-SIM336>3.0.CO;2-Z CAS PubMed Web of Science® Google Scholar
- 13Dyba T, Hakulinen T. Comparison of different approaches to incidence prediction based on simple interpolation techniques. Stat Med 2000; 19: 1741–1752.
10.1002/1097-0258(20000715)19:13<1741::AID-SIM496>3.0.CO;2-O CAS PubMed Web of Science® Google Scholar
- 14Dyba T, Hakulinen T, Paivarinta L. A simple non-linear model in incidence prediction. Stat Med 1997; 16: 2297–2309.
10.1002/(SICI)1097-0258(19971030)16:20<2297::AID-SIM668>3.0.CO;2-F CAS PubMed Web of Science® Google Scholar
- 15 Association of the Nordic Cancer Registries. Danish Cancer Society. NORDCAN: Cancer Incidence, Mortality, Prevalence and Survival in the Nordic Countries, Version 5.2 (December 2012) [database on the Internet]. 2012. URL http://www.dep.iarc.fr/nordcan.htm. (last accessed: 06 February 2013).
- 16 Integraal Kankercentrum Nederland. Cijfers over kanker. [database on the Internet] 2013. URL www.cijfersoverkanker.nl.
- 17Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer 2013; 49: 1374–1403.
- 18Znaor A, van den Hurk C, Primic-Zakelj M et al. Cancer incidence and mortality patterns in South Eastern Europe in the last decade: gaps persist compared with the rest of Europe. Eur J Cancer 2013; 49: 1683–1691.
- 19Gondos A, Bray F, Hakulinen T, Brenner H. Trends in cancer survival in 11 European populations from 1990 to 2009: a model-based analysis. Ann Oncol 2009; 20: 564–573.
- 20Ferlay J, Parkin DM, Steliarova-Foucher E. Estimates of cancer incidence and mortality in Europe in 2008. Eur J Cancer 2010; 46: 765–781.
- 21Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010; 127: 2893–2917.
- 22La Vecchia C, Lucchini F, Negri E, Levi F. Recent declines in worldwide mortality from cutaneous melanoma in youth and middle age. Int J Cancer 1999; 81: 62–66.
10.1002/(SICI)1097-0215(19990331)81:1<62::AID-IJC12>3.0.CO;2-2 CAS PubMed Web of Science® Google Scholar
- 23Hollestein LM, van den Akker SA, Nijsten T, Karim-Kos HE, Coebergh JW, de Vries E. Trends of cutaneous melanoma in The Netherlands: increasing incidence rates among all Breslow thickness categories and rising mortality rates since 1989. Ann Oncol 2012; 23: 524–530.
- 24Aceituno-Madera P, Buendia-Eisman A, Arias-Santiago S, Serrano-Ortega S. [Changes in the incidence of skin cancer between 1978 and 2002] Evolucion de la incidencia del cancer de piel en el periodo 1978-2002. Actas Dermosifiliogr 2010; 101: 39–46.
- 25Cicarma E, Juzeniene A, Porojnicu AC, Bruland OS, Moan J. Latitude gradient for melanoma incidence by anatomic site and gender in Norway 1966-2007. J Photochem Photobiol, B 2010; 101: 174–178.
- 26Crocetti E, Carli P, Miccinesi G. Melanoma incidence in central Italy will go on increasing also in the near future: a registry-based, age-period-cohort analysis. Eur J Cancer Prev 2007; 16: 50–54.
- 27de Vries E, Coebergh JW. Cutaneous malignant melanoma in Europe. Eur J Cancer 2004; 40: 2355–2366.
- 28Fuglede NB, Brinck-Claussen UO, Deltour I, Boesen EH, Dalton SO, Johansen C. Incidence of cutaneous malignant melanoma in Denmark, 1978-2007. Br J Dermatol 2011; 165: 349–353.
- 29Juzeniene A, Micu E, Porojnicu AC, Moan J. Malignant melanomas on head/neck and foot: differences in time and latitudinal trends in Norway. J Eur Acad Dermatol Venereol 2012; 26: 821–827.
- 30Stang A, Pukkala E, Sankila R, Soderman B, Hakulinen T. Time trend analysis of the skin melanoma incidence of Finland from 1953 through 2003 including 16,414 cases. Int J Cancer 2006; 119: 380–384.
- 31Marcos-Gragera R, Vilar-Coromina N, Galceran J et al. Rising trends in incidence of cutaneous malignant melanoma and their future projections in Catalonia, Spain: increasing impact or future epidemic? J Eur Acad Dermatol Venereol 2010; 24: 1083–1088.
- 32Katalinic A, Kunze U, Schafer T. Epidemiology of cutaneous melanoma and non-melanoma skin cancer in Schleswig-Holstein, Germany: incidence, clinical subtypes, tumour stages and localization (epidemiology of skin cancer). Br J Dermatol 2003; 149: 1200–1206.
- 33Waldmann A, Nolte S, Weinstock MA et al. Skin cancer screening participation and impact on melanoma incidence in Germany–an observational study on incidence trends in regions with and without population-based screening. Br J Cancer 2012; 106: 970–974.
- 34de Vries E, Arnold M, Altsitsiadis E et al. Potential impact of interventions resulting in reduced exposure to ultraviolet (UV) radiation (UVA and UVB) on skin cancer incidence in four European countries, 2010-2050. Br J Dermatol 2012; 167(Suppl 2): 53–62.
- 35Breitbart EW, Waldmann A, Nolte S et al. Systematic skin cancer screening in Northern Germany. J Am Acad Dermatol 2012; 66: 201–211.
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