Randomized controlled trial of the effect of periodontal treatment on cardiovascular risk biomarkers in patients with stable coronary artery disease: Preliminary findings of 3 months
Marlon M. Montenegro
Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Search for more papers by this authorIngrid W. J. Ribeiro
Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Search for more papers by this authorCassio Kampits
Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Search for more papers by this authorMarco A. L. Saffi
Cardiology Division, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Search for more papers by this authorMariana V. Furtado
Service of Cardiology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
Search for more papers by this authorCarisi A. Polanczyk
Cardiology Division, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Search for more papers by this authorCorresponding Author
Alex N. Haas
Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Correspondence
Alex Nogueira Haas, Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Email: [email protected]
Search for more papers by this authorCassiano K. Rösing
Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Search for more papers by this authorMarlon M. Montenegro
Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Search for more papers by this authorIngrid W. J. Ribeiro
Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Search for more papers by this authorCassio Kampits
Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Search for more papers by this authorMarco A. L. Saffi
Cardiology Division, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Search for more papers by this authorMariana V. Furtado
Service of Cardiology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
Search for more papers by this authorCarisi A. Polanczyk
Cardiology Division, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Search for more papers by this authorCorresponding Author
Alex N. Haas
Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Correspondence
Alex Nogueira Haas, Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Email: [email protected]
Search for more papers by this authorCassiano K. Rösing
Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Search for more papers by this authorFunding information
This study was funded by two grants, one from the Brazilian Ministry of Science and Technology (CNPq 476387/2010-8) and another from the Research Support Agency from Rio Grande do Sul State (FAPERGS 1008214). Funding had also been provided by the Funding for Research and Events from the University Hospital of Porto Alegre. The authors have stated explicitly that there are no conflicts of interest in connection with this article.
Abstract
Aim
To assess the effect of periodontal therapy (PT) on cardiovascular blood biomarkers.
Materials and Methods
This single-blind, parallel-design, randomized controlled trial included patients with stable coronary artery disease and periodontitis. The test group (TG) received non-surgical PT, whereas the control group (CG) received one session of plaque removal. Plasma levels of C-reactive protein (CRP), glycated haemoglobin, lipids and cytokines (IL-1β, IL-6, IL-8, IL-10, IFN-γ and TNF-α) were measured at baseline and after 3 months.
Results
Eighty-two patients (74.4% women, mean age 59.6 years) were analysed. TG had significantly better periodontal parameters than CG after 3 months, but no significant differences in blood markers were observed between them. In a post hoc subgroup analysis in patients with baseline CRP <3 mg/L, a significant increase in CRP was observed in CG (1.44 ± 0.82 mg/L to 4.35 ± 7.85 mg/L, p = 0.01), whereas CRP remained unchanged in TG (1.40 ± 0.96 mg/L to 1.33 ± 1.26 mg/L, p = 0.85), resulting in a significant difference between groups at 3 months. In patients with CRP ≥3 mg/L, a significant reduction in CRP was observed only in TG (11.3 ± 12.8 mg/L to 5.7 ± 4.1 mg/L, p = 0.04). Levels of IL-6 and IL-8 were significantly lower in TG than CG at 3 months.
Conclusions
PT leads to lower levels of CRP, IL-6 and IL-8 in cardiovascular patients with high CRP levels.
CONFLICT OF INTEREST
The authors have stated explicitly that there are no conflicts of interest in connection with this article.
Supporting Information
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