Java project on periodontal diseases: periodontal bone loss in relation to environmental and systemic conditions
A. Amaliya
Department of Periodontology, Padjadjaran State University, Bandung, Indonesia
Search for more papers by this authorMarja L. Laine
Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands
Search for more papers by this authorJoris R. Delanghe
Department of Laboratory Medicine, Ghent University Hospital, Ghent, Belgium
Search for more papers by this authorBruno G. Loos
Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands
Search for more papers by this authorArjen J. Van Wijk
Department of Social Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Amsterdam, The Netherlands
Search for more papers by this authorCorresponding Author
Ubele Van der Velden
Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands
Address:
Ubele Van der Velden
Department of Periodontology
Academic Centre for Dentistry Amsterdam
Gustav Mahlerlaan 3004
1081 LA Amsterdam
The Netherlands
E-mail: [email protected]
Search for more papers by this authorA. Amaliya
Department of Periodontology, Padjadjaran State University, Bandung, Indonesia
Search for more papers by this authorMarja L. Laine
Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands
Search for more papers by this authorJoris R. Delanghe
Department of Laboratory Medicine, Ghent University Hospital, Ghent, Belgium
Search for more papers by this authorBruno G. Loos
Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands
Search for more papers by this authorArjen J. Van Wijk
Department of Social Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Amsterdam, The Netherlands
Search for more papers by this authorCorresponding Author
Ubele Van der Velden
Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands
Address:
Ubele Van der Velden
Department of Periodontology
Academic Centre for Dentistry Amsterdam
Gustav Mahlerlaan 3004
1081 LA Amsterdam
The Netherlands
E-mail: [email protected]
Search for more papers by this authorConflict of interest and source of funding statement
The authors declare no competing financial interests. This research has been partly supported by a grant of Nuffic (Netherlands Fellowship Programmes, CF 7454/) to author A. Authors M.L.L., B.G.L. and U.vd.V. are supported in part by a grant from the University of Amsterdam, the Netherlands, for the focal point “Oral infection and inflammation”.
Abstract
Objective
To assess in a population deprived from regular dental care the relationship between alveolar bone loss (ABL) and environmental/systemic conditions.
Material & Methods
The study population consisted of subjects from the Purbasari tea estate on West Java, Indonesia. A full set of dental radiographs was obtained of each subject and amount of ABL was assessed. In addition, the following parameters were evaluated: plasma vitamin C, vitamin D3, HbA1c and CRP, the haptoglobin phenotype, presence of putative periodontopathic bacteria and viruses, dietary habits, smoking and anthropometrics.
Results
In this population 45% showed vitamin C depletion/deficiency, 82% had vitamin D3 insufficiency/deficiency, 70% were in a pre-diabetic state, 6% had untreated diabetes, 21% had elevated CRP values ranging from 3.1 to 16.1 mg/l. Results of the regression analysis, including all above mentioned parameters, showed four significant predictors, explaining 19.8% of the variance of ABL. Number of Porphyromonas gingivalis cells and CRP values showed a positive relationship with ABL, whereas BMI and number of guava fruit servings were negatively related.
Conclusion
Results confirm previous findings that elevated levels of P. gingivalis may be indicative for periodontitis progression. A new finding is that guava fruit consumption may play a protective role in periodontitis in a malnourished population.
Supporting Information
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| jcpe12381-sup-0001-supinfo.docxWord document, 16.1 KB | Appendix S1. Laboratory procedures. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
References
- Alshouibi, E. N., Kaye, E. K., Cabral, H. J., Leone, C. W. & Garcia, R. I. (2013) Vitamin D and periodontal health in older men. Journal of Dental Research 92, 689–693.
- Amaliya, A., Timmerman, M. F., Abbas, F., Loos, B. G., Van der Weijden, G. A., Van Winkelhoff, A. J., Winkel, E. G. & Van der Velden, U. (2007) Java Project on periodontal disease: the relationship between vitamin C and the severity of periodontitis. Journal of Clinical Periodontology 34, 299–304.
- Amarasena, N., Ogawa, H., Yoshihara, A., Hanada, N. & Miyazaki, H. (2005) Serum vitamin C-periodontal relationship in community-dwelling elderly Japanese. Journal of Clinical Periodontology 32, 93–97.
- Antonoglou, G., Knuuttila, M., Niemelä, O., Hiltunen, L., Raunio, T., Karttunen, R., Vainio, O., Ylöstalo, P. & Tervonen, T. (2013) Serum 1,25(OH)D level increases after elimination of periodontal inflammation in T1DM subjects. The Journal of Clinical Endocrinology & Metabolism 98, 3999–4005.
- Barclay, A. W., Petocz, P., McMillan-Price, J., Flood, V. M., Prvan, T., Mitchell, P. & Brand-Miller, J. C. (2008) Glycemic index, glycemic load, and chronic disease risk—a meta-analysis of observational studies. American Journal of Clinical Nutrition 87, 627–637.
- Bergström, J. (2004) Tobacco smoking and chronic destructive periodontal disease. Odontology 92, 1–8.
- Bosy-Westphal, A., Booke, C. A., Blöcker, T., Kossel, E., Goele, K., Later, W., Hitze, B., Heller, M., Glüer, C. C. & Müller, M. J. (2010) Measurement site for waist circumference affects its accuracy as an index of visceral and abdominal subcutaneous fat in a Caucasian population. The Journal of Nutrition 140, 954–961.
- Cahill, L. E. & El-Sohemy, A. (2010) Haptoglobin genotype modifies the association between dietary vitamin C and serum ascorbic acid deficiency. American Journal of Clinical Nutrition 92, 1494–1500.
- Chapple, I. L., Milward, M. R. & Dietrich, T. (2007) The prevalence of inflammatory periodontitis is negatively associated with serum antioxidant concentrations. The Journal of Nutrition 137, 657–664.
- Chávarry, N. G., Vettore, M. V., Sansone, C. & Sheiham, A. (2009) The relationship between diabetes mellitus and destructive periodontal disease: a meta-analysis. Oral Health & Preventive Dentistry 7, 107–127.
- Chiolero, A., Faeh, D., Paccaud, F. & Cornuz, J. (2008) Consequences of smoking for body weight, body fat distribution, and insulin resistance. American Journal of Clinical Nutrition 87, 801–809.
- Chow, J. & Mazmanian, S. K. (2010) A pathobiont of the microbiota balances host colonization and intestinal inflammation. Cell Host & Microbe 7, 265–276.
- Cugini, C., Klepac-Ceraj, V., Rackaityte, E., Riggs, J. E. & Davey, M. E. (2013) Porphyromonas gingivalis: keeping the pathos out of the biont. Journal of Oral Microbiology 5, 19804.
- Delanghe, J. R., Langlois, M. R., De Buyzere, M. L. & Torck, M. A. (2007) Vitamin C deficiency and scurvy are not only a dietary problem but are codetermined by the haptoglobin polymorphism. Clinical Chemistry 53, 1397–1400.
- Dietrich, T., Joshipura, K. J., Dawson-Hughes, B. & Bischoff-Ferrari, H. A. (2004) Association between serum concentrations of 25-hydroxyvitamin D3 and periodontal disease in the US population. American Journal of Clinical Nutrition 80, 108–113.
- Dietrich, T., Nunn, M., Dawson-Hughes, B. & Bischoff-Ferrari, H. A. (2005) Association between serum concentrations of 25-hydroxyvitamin D and gingival inflammation. American Journal of Clinical Nutrition 82, 575–580.
- Gomes, M. S., Blattner, T. C., Sant'Ana Filho, M., Grecca, F. S., Hugo, F. N., Fouad, A. F. & Reynolds, M. A. (2013) Can apical periodontitis modify systemic levels of inflammatory markers? A systematic review and meta-analysis. Journal of Endodontics 39, 1205–1217.
- Grossi, S. G., Zambon, J. J., Ho, A. W., Koch, G., Dunford, R. G., Machtei, E. E., Norderyd, O. M. & Genco, R. J. (1994) Assessment of risk for periodontal disease. I. Risk indicators for attachment loss. Journal of Periodontology 65, 260–267.
- Hiremath, V. P., Rao, C. B., Naik, V. & Prasad, K. V. (2013) Anti-inflammatory effect of vitamin D on gingivitis: a dose-response randomised control trial. Oral Health & Preventive Dentistry 11, 61–69.
- Holick, M. F. (2008) Deficiency of sunlight and vitamin D. BMJ 336, 1318–1319.
- Ismail, A. I., Burt, B. A. & Eklund, S. A. (1983) Relation between ascorbic acid intake and periodontal disease in the United States. Journal of the American Dental Association 107, 927–931.
- Kuzmanova, D., Jansen, I. D., Schoenmaker, T., Nazmi, K., Teeuw, W. J., Bizzarro, S., Loos, B. G. & Van der Velden, U. (2012) Vitamin C in plasma and leucocytes in relation to periodontitis. Journal of Clinical Periodontology 39, 905–912.
- Langlois, M. R., Delanghe, J. R., De Buyzere, M. L., Bernard, D. R. & Ouyang, J. (1997) Effect of haptoglobin on the metabolism of vitamin C. American Journal of Clinical Nutrition 66, 606–610.
- Liu, K., Meng, H., Tang, X., Xu, L., Zhang, L., Chen, Z., Shi, D., Feng, X. & Lu, R. (2009) Elevated plasma calcifediol is associated with aggressive periodontitis. Journal of Periodontology 80, 1114–1120.
- MacLaughlin, J. & Holick, M. F. (1985) Aging decreases the capacity of human skin to produce vitamin D3. Journal of Clinical Investigation 76, 1536–1538.
- Marton, I. J. & Kiss, C. (1992) Influence of surgical treatment of periapical lesions on serum and blood levels of inflammatory mediators. International Endodontic Journal 25, 229–233.
- Miley, D. D., Garcia, M. N., Hildebolt, C. F., Shannon, W. D., Couture, R. A., Anderson Spearie, C. L., Dixon, D. A., Langenwalter, E. M., Mueller, C. & Civitelli, R. (2009) Cross-sectional study of vitamin D and calcium supplementation effects on chronic periodontitis. Journal of Periodontology 80, 1433–1439.
- Millen, A. E., Hovey, K. M., LaMonte, M. J., Swansonm, M., Andrews, C. A., Kluczynski, M. A., Genco, R. J. & Wactawski-Wende, J. (2013) Plasma 25-hydroxyvitamin D concentrations and periodontal disease in postmenopausal women. Journal of Periodontology 84, 1243–1256.
- Miller, J. B., Pang, E. & Bramall, L. (1992) Rice: a high or low glycemic index food? American Journal of Clinical Nutrition 56, 1034–1036.
- Moore, W. E., Moore, L. H., Ranney, R. R., Smibert, R. M., Burmeister, J. A. & Schenkein, H. A. (1991) The microflora of periodontal sites showing active destructive progression. Journal of Clinical Periodontology 18, 729–739.
- Morita, I., Inagaki, K., Nakamura, F., Noguchi, T., Matsubara, T., Yoshii, S., Nakagaki, H., Mizuno, K., Sheiham, A. & Sabbah, W. (2012) Relationship between periodontal status and levels of glycated hemoglobin. Journal of Dental Research 91, 161–166.
- Nishida, M., Grossi, S. G., Dunford, R. G., Ho, A. W., Trevisan, M. & Genco, R. J. (2000) Dietary vitamin C and the risk for periodontal disease. Journal of Periodontology 71, 1215–1223.
- Osborne, J. W. (2010) Improving your data transformations: applying the Box-Cox transformation. Practical Assessment, Research & Evaluation 15, 1–9.
- Panjamurthy, K., Manoharan, S. & Ramachandran, C. R. (2005) Lipid peroxidation and antioxidant status in patients with periodontitis. Cellular and Molecular Biology Letters 10, 255–264.
- Paraskevas, S., Huizinga, J. D. & Loos, B. G. (2008) A systematic review and meta-analyses on C-reactive protein in relation to periodontitis. Journal of Clinical Periodontology 35, 277–290.
- Preus, H. R., Anerud, A., Boysen, H., Dunford, R. G., Zambon, J. J. & Löe, H. (1995) The natural history of periodontal disease. The correlation of selected microbiological parameters with disease severity in Sri Lankan tea workers. Journal of Clinical Periodontology 22, 674–678.
- Slots, J. (2010) Human viruses in periodontitis. Periodontology 2000 (53), 89–110.
- Slots, J. & Ting, M. (1999) Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in human periodontal disease: occurrence and treatment. Periodontology 2000 20, 82–121.
- Socransky, S. S., Smith, C. & Haffajee, A. D. (2002) Subgingival microbial profiles in refractory periodontal disease. Journal of Clinical Periodontology 29, 260–268.
- Suvan, J., D'Aiuto, F., Moles, D. R., Petrie, A. & Donos, N. (2011) Association between overweight/obesity and periodontitis in adults. A systematic review. Obesity Reviews 12, 381–404.
- Taylor, C. A., Hampl, J. S. & Johnston, C. S. (2000) Low intakes of vegetables and fruits, especially citrus fruits, lead to inadequate vitamin C intakes among adults. European Journal of Clinical Nutrition 54, 573–578.
- Timmerman, M. F., Van der Weijden, G. A., Abbas, F., Arief, E. M., Armand, S., Winkel, E. G., Van Winkelhoff, A. J. & Van der Velden, U. (2000) Untreated periodontal disease in Indonesian adolescents. Longitudinal clinical data and prospective clinical and microbiological risk assessment. Journal of Clinical Periodontology 27, 932–942.
- Timmerman, M. F., Van der Weijden, G. A., Arief, E. M., Armand, S., Abbas, F., Winkel, E. G., Van Winkelhoff, A. J. & Van der Velden, U. (2001) Untreated periodontal disease in Indonesian adolescents. Subgingival microbiota in relation to experienced progression of periodontitis. Journal of Clinical Periodontology 28, 617–627.
- USDA (2010) National Nutrient Database for Standard Reference, release 26. http://ndb.nal.usda.gov/ndb/foods/show/2293?fg=&man=&lfacet=&format=Full&count=&max=25&offset=&sort=&qlookup=guava.
- Väänänen, M. K., Markkanen, H. A., Tuovinen, V. J., Kullaa, A. M., Karinpää, A. M. & Kumpusalo, E. A. (1993) Periodontal health related to plasma ascorbic acid. Proceedings of the Finnish Dental Society 89, 51–59.
- Van der Velden, U., Abbas, F., Armand, S., Loos, B. G., Timmerman, M. F., Van der Weijden, G. A., Van Winkelhoff, A. J. & Winkel, E. G. (2006) Java project on periodontal diseases. The natural development of periodontitis: risk factors, risk predictors and risk determinants. Journal of Clinical Periodontology 33, 540–548.
- Van der Velden, U., Kuzmanova, D. & Chapple, I. L. (2011) Micronutritional approaches to periodontal therapy. Journal of Clinical Periodontology 38 (Suppl 11), 142–158.
- Van Winkelhoff, A. J., Loos, B. G., Van der Reijden, W. A. & Van der Velden, U. (2002) Porphyromonas gingivalis, Bacteroides forsythus and other putative periodontal pathogens in subjects with and without periodontal destruction. Journal of Clinical Periodontology 29, 1023–1028.
- Vogel, R. I. & Wechsler, S. M. (1979) Nutritional survey of patients with moderate to severe periodontitis. Clinical and Preventive Dentistry 1, 35–38.
- WHO (2000) The Asian-Pasific perspective: redefining obesity and its treatment. http://www.wpro.who.int/nutrition/documents/Redefining_obesity/en/.
- Woot-Tsuen, W. L., Busson, F. & Jardin, C. (1968) Food composition table for use in Africa. FAO corporate document repository. Rome, Italy. http://www.fao.org/docrep/003/X6877E/X6877E00.htm#TOC.
- Wrieden, W. L., Hannah, M. K., Bolton-Smith, C., Tavendale, R., Morrison, C. & Tunstall-Pedoe, H. (2000) Plasma vitamin C and food choice in the third Glasgow MONICA population survey. Journal of Epidemiology & Community Health 54, 355–360.
- Zhan, Y., Samietz, S., Holtfreter, B., Hannemann, A., Meisel, P., Nauck, M., Völzke, H., Wallaschofski, H., Dietrich, T. & Kocher, T. (2014) Prospective Study of Serum 25-hydroxy Vitamin D and Tooth Loss. Journal of Dental Research 93, 639–644.
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