Outcome of Patients With Cardiac Sarcoidosis Who Received Cardiac Resynchronization Therapy: Comparison With Dilated Cardiomyopathy Patients
Corresponding Author
KUNIO YUFU M.D., Ph.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Address for correspondence: Kunio Yufu, M.D., Ph.D., Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama, Yufu, Oita 879-5593, Japan. Fax: +81-97-586-5797; E-mail: [email protected]Search for more papers by this authorHIDEKAZU KONDO M.D., Ph.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Search for more papers by this authorTETSUJI SHINOHARA M.D., Ph.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Search for more papers by this authorKYOKO KAWANO M.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Search for more papers by this authorYUMI ISHII M.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Search for more papers by this authorMIHO MIYOSHI M.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Search for more papers by this authorTAKAAKI IMAMURA M.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Search for more papers by this authorSHOTARO SAITO M.D., Ph.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Search for more papers by this authorNORIHIRO OKADA M.D., Ph.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Search for more papers by this authorHIDEFUMI AKIOKA M.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Search for more papers by this authorYASUSHI TESHIMA M.D., Ph.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Search for more papers by this authorMIKIKO NAKAGAWA M.D., Ph.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Search for more papers by this authorNAOHIKO TAKAHASHI M.D., Ph.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Search for more papers by this authorCorresponding Author
KUNIO YUFU M.D., Ph.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Address for correspondence: Kunio Yufu, M.D., Ph.D., Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama, Yufu, Oita 879-5593, Japan. Fax: +81-97-586-5797; E-mail: [email protected]Search for more papers by this authorHIDEKAZU KONDO M.D., Ph.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Search for more papers by this authorTETSUJI SHINOHARA M.D., Ph.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Search for more papers by this authorKYOKO KAWANO M.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Search for more papers by this authorYUMI ISHII M.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Search for more papers by this authorMIHO MIYOSHI M.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Search for more papers by this authorTAKAAKI IMAMURA M.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Search for more papers by this authorSHOTARO SAITO M.D., Ph.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Search for more papers by this authorNORIHIRO OKADA M.D., Ph.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Search for more papers by this authorHIDEFUMI AKIOKA M.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Search for more papers by this authorYASUSHI TESHIMA M.D., Ph.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Search for more papers by this authorMIKIKO NAKAGAWA M.D., Ph.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Search for more papers by this authorNAOHIKO TAKAHASHI M.D., Ph.D.
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan
Search for more papers by this authorDisclosures: None.
Cardiac Sarcoidosis and CRT Outcome
Introduction
Cardiac resynchronization therapy (CRT) has been shown to be effective for patients with chronic heart failure; however, the efficacy of CRT in patients with cardiac sarcoidosis (CS) has not been established.
Methods
We compared the outcomes of patients with CS who received CRT to patients with dilated cardiomyopathy (DCM). The incidence of major adverse cerebral and cardiovascular events (MACCE) in 11 consecutive CS patients (8 females; mean age, 66 ± 8.0 years) who received CRT were compared with 29 DCM patients (9 females; mean age, 70 ± 8.9 years).
Results
Females and patients with previous right ventricular pacing were largely included in the comparison of CS and DCM patients (P < 0.05 and P < 0.0001, respectively). During the mean follow-up period (465 ± 383 days for CS and 729 ± 393 days for DCM), MACCE were evident in 9 patients (23%); specifically, 5 CS and 4 DCM patients developed MACCE (45% vs. 14%, P < 0.05), respectively. Kaplan–Meier survival analysis demonstrated that CS patients had a higher prevalence of MACCE than DCM patients (log rank = 6.306, P = 0.0120; and Wilcoxon = 7.1333, P = 0.0076). Based on univariate analysis, the etiology of CS was associated with MACCE.
Conclusion
Our results suggest that the long-term outcome of CRT in patients with CS was very poor compared with DCM patients. Thus, caution should be exercised regarding the indication of CRT in patients with CS.
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