Proton pump inhibitors omeprazole, lansoprazole and pantoprazole induce relaxation in the rat lower oesophageal sphincter
A. Sencer Yurtsever
Department of Pharmacology, Medical Faculty, Mersin University Campus Yenişehir, Mersin
Search for more papers by this authorMehtap Pektas
Department of Pharmacology, Medical Faculty, Mersin University Campus Yenişehir, Mersin
Search for more papers by this authorMehtap Ozkur
Department of Pharmacology, Medical Faculty, Gaziantep University, Gaziantep
Search for more papers by this authorIsmail Un
Department of Pharmacology, Medical Faculty, Mersin University Campus Yenişehir, Mersin
Search for more papers by this authorAydın Erenmemisoglu
Department of Pharmacology, Medical Faculty, Erciyes University, Kayseri, Turkey
Search for more papers by this authorCorresponding Author
Kansu Buyukafsar
Department of Pharmacology, Medical Faculty, Mersin University Campus Yenişehir, Mersin
Kansu Buyukafsar, Department of Pharmacology, Medical Faculty, Mersin University Campus Yenişehir, Mersin, Turkey. E-mail: [email protected]Search for more papers by this authorA. Sencer Yurtsever
Department of Pharmacology, Medical Faculty, Mersin University Campus Yenişehir, Mersin
Search for more papers by this authorMehtap Pektas
Department of Pharmacology, Medical Faculty, Mersin University Campus Yenişehir, Mersin
Search for more papers by this authorMehtap Ozkur
Department of Pharmacology, Medical Faculty, Gaziantep University, Gaziantep
Search for more papers by this authorIsmail Un
Department of Pharmacology, Medical Faculty, Mersin University Campus Yenişehir, Mersin
Search for more papers by this authorAydın Erenmemisoglu
Department of Pharmacology, Medical Faculty, Erciyes University, Kayseri, Turkey
Search for more papers by this authorCorresponding Author
Kansu Buyukafsar
Department of Pharmacology, Medical Faculty, Mersin University Campus Yenişehir, Mersin
Kansu Buyukafsar, Department of Pharmacology, Medical Faculty, Mersin University Campus Yenişehir, Mersin, Turkey. E-mail: [email protected]Search for more papers by this authorAbstract
Objectives We aimed to investigate effects of the proton pump inhibitors (PPIs) omeprazole, lansoprazole and pantoprazole, which are currently used for the treatment of hyperacidity and gastro-oesophageal reflux, on the reactivity of the isolated rat lower oesophageal sphincter.
Methods Omeprazole, lansoprazole and pantoprazole (all 10–9–10–3m, cumulatively) were tested on carbachol-induced (10–6m) contraction. In addition, the effects of PPI preincubation (all 10–3m) on the contractions induced by cumulative carbachol (10−9–10−5m), angiotensin-2 (10−9–10–5m) or electrical field stimulation (EFS; 40 V, 32 Hz, 1 ms, 10 s) were assessed. Finally, the effects of PPI on the spontaneous contractile activity of the tissue were also evaluated.
Key findings PPI relaxed precontracted lower oesophageal sphincter in a concentration-dependent manner and suppressed carbachol-, angiotensin- and EFS-induced contractions. Furthermore, PPI attenuated spontaneous contractile activity of the tissue.
Conclusions Omeprazole, lansoprazole and pantoprazole had a suppressor effect on lower oesophageal sphincter contractions.
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