Effect of Bakuchiol on Leukocyte Functions and Some Inflammatory Responses in Mice
María Luisa Ferrándiz
Departamento de Farmacología, Universidad de Valencia, Facultad de Farmacia, Avda. Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain
Search for more papers by this authorBlanca Gil
Departamento de Farmacología, Universidad de Valencia, Facultad de Farmacia, Avda. Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain
Search for more papers by this authorMaría Jesús Sanz
Departamento de Farmacología, Universidad de Valencia, Facultad de Farmacia, Avda. Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain
Search for more papers by this authorAmalia Ubeda
Departamento de Farmacología, Universidad de Valencia, Facultad de Farmacia, Avda. Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain
Search for more papers by this authorSilvia Erazo
Departamento de Química Farmacológica y Toxicológica, Universidad de Chile, Facultad de Ciencias Químicas y Farmacéuticas, Casilla 233, Santiago-1, Chile
Search for more papers by this authorErnesto González
Departamento de Química Farmacológica y Toxicológica, Universidad de Chile, Facultad de Ciencias Químicas y Farmacéuticas, Casilla 233, Santiago-1, Chile
Search for more papers by this authorRosa Negrete
Departamento de Química Farmacológica y Toxicológica, Universidad de Chile, Facultad de Ciencias Químicas y Farmacéuticas, Casilla 233, Santiago-1, Chile
Search for more papers by this authorSergio Pacheco
Departamento de Biología Geral, Universidade Federal de Viçosa, 36570 Viçosa, Brasil
Search for more papers by this authorMiguel Payáa
Departamento de Farmacología, Universidad de Valencia, Facultad de Farmacia, Avda. Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain
Search for more papers by this authorCorresponding Author
Maráa José Alcaraz
Departamento de Farmacología, Universidad de Valencia, Facultad de Farmacia, Avda. Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain
Departamento de Farmacología, Universidad de Valencia, Facultad de Farmacia, Avda. Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain.Search for more papers by this authorMaría Luisa Ferrándiz
Departamento de Farmacología, Universidad de Valencia, Facultad de Farmacia, Avda. Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain
Search for more papers by this authorBlanca Gil
Departamento de Farmacología, Universidad de Valencia, Facultad de Farmacia, Avda. Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain
Search for more papers by this authorMaría Jesús Sanz
Departamento de Farmacología, Universidad de Valencia, Facultad de Farmacia, Avda. Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain
Search for more papers by this authorAmalia Ubeda
Departamento de Farmacología, Universidad de Valencia, Facultad de Farmacia, Avda. Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain
Search for more papers by this authorSilvia Erazo
Departamento de Química Farmacológica y Toxicológica, Universidad de Chile, Facultad de Ciencias Químicas y Farmacéuticas, Casilla 233, Santiago-1, Chile
Search for more papers by this authorErnesto González
Departamento de Química Farmacológica y Toxicológica, Universidad de Chile, Facultad de Ciencias Químicas y Farmacéuticas, Casilla 233, Santiago-1, Chile
Search for more papers by this authorRosa Negrete
Departamento de Química Farmacológica y Toxicológica, Universidad de Chile, Facultad de Ciencias Químicas y Farmacéuticas, Casilla 233, Santiago-1, Chile
Search for more papers by this authorSergio Pacheco
Departamento de Biología Geral, Universidade Federal de Viçosa, 36570 Viçosa, Brasil
Search for more papers by this authorMiguel Payáa
Departamento de Farmacología, Universidad de Valencia, Facultad de Farmacia, Avda. Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain
Search for more papers by this authorCorresponding Author
Maráa José Alcaraz
Departamento de Farmacología, Universidad de Valencia, Facultad de Farmacia, Avda. Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain
Departamento de Farmacología, Universidad de Valencia, Facultad de Farmacia, Avda. Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain.Search for more papers by this authorAbstract
The effects of bakuchiol, a meroterpenoid isolated from the leaves of Psoralea glandulosa L., on phospholipase A2 (PLA2) activity from different sources, human neutrophil responses, zymosan air pouch and topical inflammation in mice, were investigated.
This natural product was a weak inhibitor of secretory and intracellular PLA2 but dose-dependently reduced the formation of LTB4 and TXB2 by human neutrophils and platelet microsomes, respectively. In addition, bakuchiol inhibited degranulation in human neutrophils, whereas superoxide generation was not affected. In mice, bakuchiol decreased cell migration, myeloperoxidase activity and eicosanoid levels in the air pouch inflammation induced by zymosan. After topical administration, this compound was effective as an inhibitor of oedema and myeloperoxidase activity in the 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ear oedema and significantly reduced the PGE2 content and ear oedema in the arachidonic acid-induced response.
Bakuchiol is a natural anti-inflammatory agent able to control leukocytic functions such as eicosanoid production, migration and degranulation in the inflammatory site.
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