Potassium markedly potentiates the effect of veratridine on dopamine release from rat superfused striatal ribbons
VALÉRIE OLIVIER
Rhǒne-Poulenc Rarer S.A., Centre de Recherche de Vitry-Alfortville, Département Biologic, 13 quai Jules Guesde, 94403 Vitry-sur-Seine Cedex, France
Search for more papers by this authorJEAN-MARIE MIQUET
Rhǒne-Poulenc Rarer S.A., Centre de Recherche de Vitry-Alfortville, Département Biologic, 13 quai Jules Guesde, 94403 Vitry-sur-Seine Cedex, France
Search for more papers by this authorMICHEL AUBENEAU
Rhǒne-Poulenc Rarer S.A., Centre de Recherche de Vitry-Alfortville, Département Biologic, 13 quai Jules Guesde, 94403 Vitry-sur-Seine Cedex, France
Search for more papers by this authorJEAN-CHARLES BLANCHARD
Rhǒne-Poulenc Rarer S.A., Centre de Recherche de Vitry-Alfortville, Département Biologic, 13 quai Jules Guesde, 94403 Vitry-sur-Seine Cedex, France
Search for more papers by this authorADAM DOBLE
Rhǒne-Poulenc Rarer S.A., Centre de Recherche de Vitry-Alfortville, Département Biologic, 13 quai Jules Guesde, 94403 Vitry-sur-Seine Cedex, France
Search for more papers by this authorCorresponding Author
ALAIN BOIREAU
Rhǒne-Poulenc Rarer S.A., Centre de Recherche de Vitry-Alfortville, Département Biologic, 13 quai Jules Guesde, 94403 Vitry-sur-Seine Cedex, France
Rhône-Poulenc Rorer S.A., Centre de Recherche de Vitry-Alfortville, Département Biologie, 13 quai Jules Guesde, 94403 Vitry-sur-Seine Cedex, France.Search for more papers by this authorVALÉRIE OLIVIER
Rhǒne-Poulenc Rarer S.A., Centre de Recherche de Vitry-Alfortville, Département Biologic, 13 quai Jules Guesde, 94403 Vitry-sur-Seine Cedex, France
Search for more papers by this authorJEAN-MARIE MIQUET
Rhǒne-Poulenc Rarer S.A., Centre de Recherche de Vitry-Alfortville, Département Biologic, 13 quai Jules Guesde, 94403 Vitry-sur-Seine Cedex, France
Search for more papers by this authorMICHEL AUBENEAU
Rhǒne-Poulenc Rarer S.A., Centre de Recherche de Vitry-Alfortville, Département Biologic, 13 quai Jules Guesde, 94403 Vitry-sur-Seine Cedex, France
Search for more papers by this authorJEAN-CHARLES BLANCHARD
Rhǒne-Poulenc Rarer S.A., Centre de Recherche de Vitry-Alfortville, Département Biologic, 13 quai Jules Guesde, 94403 Vitry-sur-Seine Cedex, France
Search for more papers by this authorADAM DOBLE
Rhǒne-Poulenc Rarer S.A., Centre de Recherche de Vitry-Alfortville, Département Biologic, 13 quai Jules Guesde, 94403 Vitry-sur-Seine Cedex, France
Search for more papers by this authorCorresponding Author
ALAIN BOIREAU
Rhǒne-Poulenc Rarer S.A., Centre de Recherche de Vitry-Alfortville, Département Biologic, 13 quai Jules Guesde, 94403 Vitry-sur-Seine Cedex, France
Rhône-Poulenc Rorer S.A., Centre de Recherche de Vitry-Alfortville, Département Biologie, 13 quai Jules Guesde, 94403 Vitry-sur-Seine Cedex, France.Search for more papers by this authorAbstract
Abstract— The effects of veratridine-induced depolarization on [3H]dopamine ([3H]DA) release in the presence of a physiological (5 Mm) or a depolarizing (25 Mm) concentration of K+ were studied in-vitro in rat superfused striatal ribbons. A combination of the two depolarizing agents induced a marked potentiation in the overflow of [3H]DA, giving an overall 3- to 5-fold increase in veratridine activity. This potentiation was completely antagonized by tetrodotoxin (100 Nm). These studies indicated that K+-induced depolarization can increase the potency of veratridine in releasing dopamine from terminals.
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