Healing of a resistant neurotrophic corneal ulcer using a new matrix therapy agent (RGTA): A case report
Abstract
Purpose
We report a case of a resistant neurotrophic corneal ulcer successfully treated by the matrix regenerating agent (RGTA) Cacicol(®).
Methods
We report a case of an 18-year-old female patient, who developed a persistent epithelial ulcer after cataract surgery complicated by endophthalmitis, with no improvement despite 4 weeks of artificial tears. A new ophthalmologic solution based on a regenerating agent (RGTA, Cacicol20®) was then used, with a dosage of two eye drops per week for 8 weeks.
Results
Improvement was observed in 2 weeks, and complete healing was obtained in <5 weeks, with no side effects.
Conclusions
This heparin mimetic, which may stimulate extracellular matrix healing, may be a possible alternative therapy to autologous serum or amniotic membrane transplantation in severe neurotrophic ulcer. However, randomized studies are necessary to confirm this encouraging result.
