Correlation of Osmolarity Measurements with Signs and Symptoms in the Norwegian Dry Eye Clinic
Abstract
Purpose
To evaluate the relationship between osmolarity and signs and symptoms of dry eye disease (DED) in a Norwegian cohort of patients with DED.
Methods
Clinical signs and symptoms were evaluated for 365 subjects at the Norwegian Dry Eye Clinic. All patients received an extensive ophthalmological work-up, including tear meniscus height, blink rate, corneal sensibility, tear film break-up time, Ocular Protection Index, vital staining, Schirmer I, meibum quality and meibum expressibility. Pearson correlations between signs and symptoms were performed. P values below 0.05 were considered significant.
Results
High osmolarity correlated with lower ocular protection index (0.32) and higher blink interval (0.12), but no other parameters.
Conclusions
Osmolarity did not correlate strongly with any parameters of dry eye disease.
