Carbohydrate-restricted versus low-glycemic-index diets for the treatment of insulin resistance and metabolic syndrome
Richard J Wood
Department of Exercise Science and Sport Studies, Springfield College, Springfield, Massachusetts, USA
Search for more papers by this authorMaria Luz Fernandez
Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut, USA.
Search for more papers by this authorRichard J Wood
Department of Exercise Science and Sport Studies, Springfield College, Springfield, Massachusetts, USA
Search for more papers by this authorMaria Luz Fernandez
Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut, USA.
Search for more papers by this authorAbstract
Carbohydrate-restricted diets (CRD) and diets comprised of foods with a low glycemic index (low-GI) are postulated to improve insulin resistance and metabolic syndrome, potentially preventing the development of type 2 diabetes mellitus (T2DM). In this article, recent findings concerning the effects of CRD and low-GI diets on measures associated with the metabolic syndrome and T2DM are discussed. An important problem that is encountered when trying to compare the effects of these different diets is the heterogeneity of carbohydrate consumption (8–40% of total kcal) used in interventions examining the effects of CRD. In contrast, there is a consensus definition for low-GI foods. However, since both quantity and type of carbohydrate powerfully affect metabolic outcomes, this review emphasizes that control of these factors in future studies will be important for determining the efficacy of either dietary approach in preventing the development of T2DM.
REFERENCES
- 1 Fernandez ML. The metabolic syndrome. Nutr Rev. 2007; 64(Suppl): S30–S34.
- 2 Mokdad AH, Ford ES, Bowman BA, et al. Prevalence of obesity, diabetes and obesity-related health risk factors, 2001. JAMA. 2003; 289: 76–79.
- 3 Jenkins DJA, Wolever TMS, Taylor RH, et al. Glycemic index of foods: a physiological basis for carbohydrate exchange. Am J Clin Nutr. 1981; 34: 362–366.
- 4 Volek JS, Feinman RD. Carbohydrate restriction improves the features of metabolic syndrome. Metabolic syndrome may be defined by the response to carbohydrate restriction. Nutr Metab. 2005; 2: 31.
- 5 Westman EC, Yancy WS, Haub MD, Volek JS. Insulin resistance from a low carbohydrate, high fat diet perspective. Metab Syndr Relat Disord. 2005; 3: 14–18.
- 6 Freeman JM, Kossoff EH, Hartman AL. The ketogenic diet: one decade later. Pediatrics. 2007; 119: 535–543.
- 7 Sondike SB, Copperman N, Jacobson MS. Effects of a low-carbohydrate diet on weight loss and cardiovascular risk factor in overweight adolescents. J Pediatr. 2003; 42: 253–258.
- 8 Yancy WS, Vernon MC, Westman EC. A pilot trial of a low-carbohydrate, ketogenic diet in patients with type 2 diabetes. Met Syndr Relat Disord. 2003; 1: 239–243.
- 9 Brehm BJ, Seeley RJ, Daniels SR, D'Alessio DA. A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women. J Clin Endocrinol Metab. 2003; 88: 1617–1623.
- 10 Gardner CD, Kiazand A, Alhassan S, et al. Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A TO Z Weight Loss Study: a randomized trial. JAMA. 2008; 297: 969–977.
- 11 McAuley KA, Hopkins CM, Smith KJ, et al. Comparison of high-fat and high-protein diets with a high-carbohydrate diet in insulin-resistant obese women. Diabetologia. 2005; 48: 8–16.
- 12 Samaha FF, Iqbal N, Seshadri P, et al. A low-carbohydrate as compared with a low-fat diet in severe obesity. N Engl J Med. 2003; 348: 2074–2081.
- 13 Luis DA, Aller R, Izaola O, Gonzalez Sagrado M, Bellioo D, Conde R. Effects of a low-fat versus a low-carbohydrate diet on adipocytokines in obese adults. Horm Res. 2007; 67: 296–300.
- 14 Wolever TMS, Gibbs AL, Mehling C, et al. The Canadian trial of carbohydrates in diabetes (CCD), a 1-y controlled trial of low-glycemic index dietary carbohydrate in type 2 diabetes: no effect on glycated hemoglobin but reduction in C-reactive protein. Am J Clin Nutr. 2008; 87: 114–125.
- 15 Dansinger ML, Gleason JA, Griffith JL, Selker HP, Schaefer EJ. Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial. JAMA. 2005; 293: 43–53.
- 16 Krauss RM, Blanch PJ, Rawlings RS, Fernstrom HS, Williams PT. Separate effects of reduced carbohydrate intake and weight loss on atherogenic dyslipidemia. Am J Clin Nutr. 2006; 83: 1025–1031.
- 17 Wood RJ, Fernandez ML, Sharman MJ, et al. Effects of a carbohydrate restricted diet with and without supplemental soluble fiber on plasma LDL-cholesterol and other clinical markers of cardiovascular risk. Metabolism. 2007; 56: 58–67.
- 18 Sharman MJ, Volek JS. Weight loss leads to reductions in inflammatory biomarkers after a very-low-carbohydrate diet and a low-fat diet in overweight men. Clin Sci (Lond). 2004; 107: 365–369.
- 19 Wood RJ, Volek JS, Liu Y, Shachter NS, Contois JH, Fernandez ML. Carbohydrate restriction alters lipoprotein metabolism by modifying VLDL, LDL and HDL subfraction distribution and size in overweight men. J. Nutr. 2006; 136: 384–389.
- 20 Volek JS, Sharman M, Gomez A, et al. Comparison of energy-restricted very low-carbohydrate and low-fat diets on weight loss and body composition in overweight men and women. Nutr Metab (Lond). 2004; 8: 13.
- 21 Dattilo AM, Kris-Etherton PM. Effects of weight reduction on blood lipids and lipoproteins: a meta-analysis. Am J Clin Nutr. 1992; 56: 320–328.
- 22 Mutungi G, Ratliff J, Puglisi M, et al. Dietary cholesterol from eggs increases HDL cholesterol in overweight men consuming a carbohydrate restricted diet. J Nutr. 2008; 138: 272–276.
- 23 Ratliff J, Mutungi G, Puglisi M, Volek JS, Fernandez ML. Eggs modulate the inflammatory response to carbohydrate restricted diets in overweight men. Nutr Metab (Lond). 2008; 5: 6.
- 24 Wood RJ, Volek JS, Davis SR, Dell'Ova C, Fernandez ML. Carbohydrate restriction favorably affects plasma markers for cardiovascular disease. Nutr Met. 2006; 3: 19.
- 25 Sharman MJ, Kraemer WJ, Love DM, et al. A ketogenic diet favorably affects serum biomarkers for cardiovascular disease in normal-weight men. J Nutr. 2002; 132: 1879–1885.
- 26 Ludwig DS. The glycemic index: physiological mechanisms relating to obesity, diabetes and cardiovascular disease. JAMA. 2002; 287: 2414–2423.
- 27 American Diabetes Association. Nutrition principles and recommendations in diabetes (position statement). Diabetes Care. 2004; 27(Suppl): S36–S46.
- 28 Vega-Lopez S, Ausman LM, Griffith JH, Lichtenstein AH. Interindividual variability and intra-individual reproducibility of glycemic index values for commercial white bread. Diabetes Care. 2007; 30: 1412–1417.
- 29 Foster-Powell K, Holt SH, Brand-Miller JC. International table of glycemic index and glycemic load values. Am J Clin Nutr. 2002; 76: 5–56.
- 30 Brand-Miller J, Hayne S, Petocz P, Colagiuri S. Low glycemic index diets in the management of diabetes. Diabetes Care. 2003; 26: 2261–2267.
- 31 Franz MJ. The glycemic index, not the most effective nutrition therapy intervention. Diabetes Care. 2003; 26: 2466–2468.
- 32 Kallio P, Kolehmainen M, Laaksonen DE, et al. Inflammation markers are modulated by responses to diets differing in postprandial insulin responses in individuals with the metabolic syndrome. Am J Clin Nutr. 2008; 87: 1497–1503.
- 33 Atkinson FS, Foster-Powell K, Brand-Miller JC. International tables of glycemic index and glycemic load values: 2008. Diabetes Care. 2008; 12: 2281–2283.
- 34 Wolever TMS, Mehling C, Chiasson J-L, et al. Low glycaemic index diet and disposition index in type 2 diabetes (The Canadian trial of carbohydrates in diabetes): a randomized control trial. Diabetologia. 2008; 51: 1607–1615.