Giant Cell Aortitis and Noonan Syndrome
Corresponding Author
Shaji Menon MD
Mayo Congenital Heart Center Mayo Clinic—Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, and
Shaji Menon, MD, Mayo Clinic Pediatric Cardiology, 200 First Street SW, Rochester, MN 55905, USA. Tel: (+1) 507-284-3297; Fax: (+1) 507-284-3968; E-mail: [email protected]Search for more papers by this authorMary E. Pierpont MD, PhD
Childrens Hospital of Minnesota and University of Minnesota—Pediatric Cardiology, Rochester, Minnesota
Search for more papers by this authorDavid Driscoll MD
Mayo Congenital Heart Center Mayo Clinic—Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, and
Search for more papers by this authorCorresponding Author
Shaji Menon MD
Mayo Congenital Heart Center Mayo Clinic—Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, and
Shaji Menon, MD, Mayo Clinic Pediatric Cardiology, 200 First Street SW, Rochester, MN 55905, USA. Tel: (+1) 507-284-3297; Fax: (+1) 507-284-3968; E-mail: [email protected]Search for more papers by this authorMary E. Pierpont MD, PhD
Childrens Hospital of Minnesota and University of Minnesota—Pediatric Cardiology, Rochester, Minnesota
Search for more papers by this authorDavid Driscoll MD
Mayo Congenital Heart Center Mayo Clinic—Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, and
Search for more papers by this authorABSTRACT
An 18-year-old girl with Noonan syndrome was diagnosed with progressive aneurysmal dilatation of the ascending aorta. Histopathological examination revealed giant cell aortitis. Connective tissue abnormalities leading to aortic root dilatation and the sinuses of Valsalva aneurysm have been reported in Noonan syndrome. This report is the first description of giant cell aortitis in Noonan syndrome and may provide a link between aortic aneurysm, and giant cell granuloma of bone in Noonan syndrome.
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