Inhibition of Lux quorum-sensing system by synthetic N-acyl-L-homoserine lactone analogous
Wenzhao Wang
Department of Material and Environmental Chemistry, Utsunomiya University, Utsunomiya, Tochigi 321-8585, Japan
College of Environmental Science and Engineering, Dong Hua University, Shanghai 201620, China
Search for more papers by this authorCorresponding Author
Tomohiro Morohoshi
Department of Material and Environmental Chemistry, Utsunomiya University, Utsunomiya, Tochigi 321-8585, Japan
*Corresponding authors:Tomohiro Morohoshi: Tel, 81-28-6896176; Fax, 81-28-6896176; E-mail, [email protected]Liang Chen: Tel, 86-21-67792548; E-mail, [email protected]Search for more papers by this authorTsukasa Ikeda
Department of Material and Environmental Chemistry, Utsunomiya University, Utsunomiya, Tochigi 321-8585, Japan
Search for more papers by this authorCorresponding Author
Liang Chen
College of Environmental Science and Engineering, Dong Hua University, Shanghai 201620, China
*Corresponding authors:Tomohiro Morohoshi: Tel, 81-28-6896176; Fax, 81-28-6896176; E-mail, [email protected]Liang Chen: Tel, 86-21-67792548; E-mail, [email protected]Search for more papers by this authorWenzhao Wang
Department of Material and Environmental Chemistry, Utsunomiya University, Utsunomiya, Tochigi 321-8585, Japan
College of Environmental Science and Engineering, Dong Hua University, Shanghai 201620, China
Search for more papers by this authorCorresponding Author
Tomohiro Morohoshi
Department of Material and Environmental Chemistry, Utsunomiya University, Utsunomiya, Tochigi 321-8585, Japan
*Corresponding authors:Tomohiro Morohoshi: Tel, 81-28-6896176; Fax, 81-28-6896176; E-mail, [email protected]Liang Chen: Tel, 86-21-67792548; E-mail, [email protected]Search for more papers by this authorTsukasa Ikeda
Department of Material and Environmental Chemistry, Utsunomiya University, Utsunomiya, Tochigi 321-8585, Japan
Search for more papers by this authorCorresponding Author
Liang Chen
College of Environmental Science and Engineering, Dong Hua University, Shanghai 201620, China
*Corresponding authors:Tomohiro Morohoshi: Tel, 81-28-6896176; Fax, 81-28-6896176; E-mail, [email protected]Liang Chen: Tel, 86-21-67792548; E-mail, [email protected]Search for more papers by this authorThis work was supported by a grant from the Shanghai Leading Academic Discipline Project (No. B604)
Abstract
In the present study, we investigated the inhibition of the Lux quorum-sensing system by N-acyl cyclopentylamine (Cn-CPA). The Lux quorum-sensing system regulates luminescence gene expression in Vibrio fischeri. We have already reported on the synthesis of Cn-CPA and their abilities as inhibitors of the quorum-sensing systems in Pseudomonas aeruginosa and Serratia marcescens. In the case of Pseudomonas aeruginosa (Las and Rhl quorum-sensing system) and Serratia marcescens (Spn quorum-sensing system), specific Cn-CPA with a particular acyl chain length showed the strongest inhibitory effect. In the case of the Lux quorum-sensing system, it was found that several kinds of Cn-CPA with a range from C5 to C10 showed similar strong inhibitory effects. Moreover, the inhibitory effect of Cn-CPA on the Lux quorum-sensing system was stronger than that of halogenated furanone, a natural quorum-sensing inhibitor.
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