Comparative Analysis of Two-component Signal Transduction System in Two Streptomycete Genomes
Wu WEI
Bioinformation Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
Shanghai Center for Bioinformation Technology, Shanghai 200235, China
These authors contributed equally to this work
Search for more papers by this authorWeihua WANG
Laboratory of Molecular Microbiology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200032, China
These authors contributed equally to this work
Search for more papers by this authorZhiwei CAO
Shanghai Center for Bioinformation Technology, Shanghai 200235, China
These authors contributed equally to this work
Search for more papers by this authorHong YU
Shanghai Center for Bioinformation Technology, Shanghai 200235, China
Search for more papers by this authorXiaojing WANG
Bioinformation Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
Search for more papers by this authorJing ZHAO
Shanghai Center for Bioinformation Technology, Shanghai 200235, China
Search for more papers by this authorHao TAN
Shanghai Center for Bioinformation Technology, Shanghai 200235, China
Search for more papers by this authorHao XU
Shanghai Center for Bioinformation Technology, Shanghai 200235, China
Search for more papers by this authorCorresponding Author
Weihong JIANG
Laboratory of Molecular Microbiology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200032, China
*Yixue LI: Tel, 86-21-64363311; Fax, 86-21-64838882; E-mail, [email protected] Weihong JIANG: Tel, 86-21-54924172; Fax, 86-21-54924015; Email, [email protected]Search for more papers by this authorCorresponding Author
Yixue LI
Bioinformation Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
Shanghai Center for Bioinformation Technology, Shanghai 200235, China
*Yixue LI: Tel, 86-21-64363311; Fax, 86-21-64838882; E-mail, [email protected] Weihong JIANG: Tel, 86-21-54924172; Fax, 86-21-54924015; Email, [email protected]Search for more papers by this authorWu WEI
Bioinformation Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
Shanghai Center for Bioinformation Technology, Shanghai 200235, China
These authors contributed equally to this work
Search for more papers by this authorWeihua WANG
Laboratory of Molecular Microbiology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200032, China
These authors contributed equally to this work
Search for more papers by this authorZhiwei CAO
Shanghai Center for Bioinformation Technology, Shanghai 200235, China
These authors contributed equally to this work
Search for more papers by this authorHong YU
Shanghai Center for Bioinformation Technology, Shanghai 200235, China
Search for more papers by this authorXiaojing WANG
Bioinformation Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
Search for more papers by this authorJing ZHAO
Shanghai Center for Bioinformation Technology, Shanghai 200235, China
Search for more papers by this authorHao TAN
Shanghai Center for Bioinformation Technology, Shanghai 200235, China
Search for more papers by this authorHao XU
Shanghai Center for Bioinformation Technology, Shanghai 200235, China
Search for more papers by this authorCorresponding Author
Weihong JIANG
Laboratory of Molecular Microbiology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200032, China
*Yixue LI: Tel, 86-21-64363311; Fax, 86-21-64838882; E-mail, [email protected] Weihong JIANG: Tel, 86-21-54924172; Fax, 86-21-54924015; Email, [email protected]Search for more papers by this authorCorresponding Author
Yixue LI
Bioinformation Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
Shanghai Center for Bioinformation Technology, Shanghai 200235, China
*Yixue LI: Tel, 86-21-64363311; Fax, 86-21-64838882; E-mail, [email protected] Weihong JIANG: Tel, 86-21-54924172; Fax, 86-21-54924015; Email, [email protected]Search for more papers by this authorThis study was supported by the grants from the National Natural Science Foundation of China (30470029, 30500107), Key Program of Basic Research of Shanghai (No. 06PJ14072), and the Major State Basic Research Development Program of China (2004CB720103, 2006CB910705, and 2007CB707803)
Abstract
Species of the genus Streptomyces are major bacteria responsible for producing most natural antibiotics. Streptomyces coelicolor A3(2) and Streptomyces avermitilis were sequenced in 2002 and 2003, respectively. Two-component signal transduction systems (TCSs), consisting of a histidine sensor kinase (SK) and a cognate response regulator (RR), form the most common mechanism of transmembrane signal transduction in prokaryotes. TCSs in S. coelicolor A3(2) have been analyzed in detail. Here, we identify and classify the SK and RR of S. avermitilis and compare the TCSs with those of S. coelicolor A3(2) by computational approaches. Phylogenetic analysis of the cognate SK-RR pairs of the two species indicated that the cognate SK-RR pairs fall into four classes according to the distribution of their orthologs in other organisms. In addition to the cognate SK-RR pairs, some potential partners of non-cognate SK-RR were found, including those of unpaired SK and orphan RR and the cross-talk between different components in either strain. Our study provides new clues for further exploration of the molecular regulation mechanism of streptomycetes with industrial importance.
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