Caspase Family Proteases and Apoptosis
Corresponding Author
Ting-Jun FAN
College of Marine Life Sciences, Division of Life Science and Technology, Ocean University of China, Qingdao 266003, China;
*Tel, 86-532-82031637; Fax, 86-532-82031637; E-mail, [email protected]Search for more papers by this authorLi-Hui HAN
College of Chemistry & Chemical Engineering, Ocean University of China, Qingdao 266003, China
Search for more papers by this authorRi-Shan CONG
College of Marine Life Sciences, Division of Life Science and Technology, Ocean University of China, Qingdao 266003, China;
Search for more papers by this authorJin LIANG
College of Marine Life Sciences, Division of Life Science and Technology, Ocean University of China, Qingdao 266003, China;
Search for more papers by this authorCorresponding Author
Ting-Jun FAN
College of Marine Life Sciences, Division of Life Science and Technology, Ocean University of China, Qingdao 266003, China;
*Tel, 86-532-82031637; Fax, 86-532-82031637; E-mail, [email protected]Search for more papers by this authorLi-Hui HAN
College of Chemistry & Chemical Engineering, Ocean University of China, Qingdao 266003, China
Search for more papers by this authorRi-Shan CONG
College of Marine Life Sciences, Division of Life Science and Technology, Ocean University of China, Qingdao 266003, China;
Search for more papers by this authorJin LIANG
College of Marine Life Sciences, Division of Life Science and Technology, Ocean University of China, Qingdao 266003, China;
Search for more papers by this authorThis work was supported by a grant from the Imbursement Project for Studied Abroad Returnees from the Ministry of Education of China (No. 980418)
Abstract
Abstract Apoptosis, or programmed cell death, is an essential physiological process that plays a critical role in development and tissue homeostasis. The progress of apoptosis is regulated in an orderly way by a series of signal cascades under certain circumstances. The caspase-cascade system plays vital roles in the induction, transduction and amplification of intracellular apoptotic signals. Caspases, closely associated with apoptosis, are aspartate-specific cysteine proteases and members of the interleukin-1 β-converting enzyme family. The activation and function of caspases, involved in the delicate caspase-cascade system, are regulated by various kinds of molecules, such as the inhibitor of apoptosis protein, Bcl-2 family proteins, calpain, and Ca2+. Based on the latest research, the members of the caspase family, caspase-cascade system and caspase-regulating molecules involved in apoptosis are reviewed.
Edited by You-Shang ZHANG
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