Glial involvement in trigeminal central sensitization1
Yu-feng XIE,
Corresponding Author
Yu-feng XIE
Department of Physiology and Pathophysiology, Xi'an Jiaotong University, Xi'an 710061, China
Department of Oral Physiology, University of Toronto, Toronto, Canada M5G 1G6
Correspondence to Dr Yu-feng XIE. Phn 1-901-448-1782. Fax 1-901-448-7300. E-mail [email protected]Search for more papers by this authorYu-feng XIE,
Corresponding Author
Yu-feng XIE
Department of Physiology and Pathophysiology, Xi'an Jiaotong University, Xi'an 710061, China
Department of Oral Physiology, University of Toronto, Toronto, Canada M5G 1G6
Correspondence to Dr Yu-feng XIE. Phn 1-901-448-1782. Fax 1-901-448-7300. E-mail [email protected]Search for more papers by this author1
Project supported by the National Natural Foundation of China (No 3057 0592, 30670693, and 30700222).
Abstract
Recent studies have indicated that trigeminal neurons exhibit central sensitization, an increase in the excitability of neurons within the central nervous system to the extent that a normally innocuous stimulus begins to produce pain after inflammation or injury, and that glial activities play a vital role in this central sensitization. The involvement of glial cells in trigeminal central sensitization contains multiple mechanisms, including interaction with glutamatergic and purinergic receptors. A better understanding of the trigeminal central sensitization mediated by glial cells will help to find potential therapeutic targets and lead to developing new analgesics for orofacial-specific pain with higher efficiency and fewer side-effects.
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