Volume 48, Issue 8 pp. 991-995
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Chemical Constituents of Siegesbeckia orientalis L.

Li-Li Wang

Li-Li Wang

Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, the Chinese Academy of Sciences , Shanghai 201203, China

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Li-Hong Hu

Corresponding Author

Li-Hong Hu

Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, the Chinese Academy of Sciences , Shanghai 201203, China

School of Pharmacy, East China University of Science and Technology , Shanghai 200237, China

*Author for correspondence. Tel (Fax): +86 (0)21 5027 2221; E-mail: <[email protected]>.Search for more papers by this author
First published: 02 August 2006
Citations: 22

Abstract

The aerial parts of Siegesbeckia have been used as the traditional Chinese medicine in the treatment of rheumatic arthritis, hypertension, malaria, neurasthenia, and snakebite. In order to find new and bioactive compounds, the chemical constituents of the aerial parts of S. orientalis L. were investigated and two new compounds, namely β-D-glucopyranosyl-ent-2-oxo-15,16-dihydroxy-pimar-8(14)-en-19-oic-late (compound 1) and [1(10)E,4Z]-8β-angeloyloxy-9α-methoxy-6α,15-dihydroxy-14-oxogermacra-1(10),4,11(13)-trien-12-oic acid 12,6-lactone (compound 2), as well as five known ent-pimarane diterpenes (compounds 3–7) were isolated. The structures of the two new compounds were identified by their physicochemical properties and spectral analysis, particularly one- and two-dimensional nuclear magnetic resonance spectral methods.

(Managing editor: Wei Wang)

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