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BASELINE AND INTERFERON-ENHANCED NATURAL KILLER CELL ACTIVITY IN RHEUMATOID ARTHRITIS
BENTE K. PEDERSEN,
JANNIE M. BEYER,
KIM KLARLUND,
INGE H. CLEMMENSEN,
Corresponding Author
BENTE K. PEDERSEN
Medical Department TA, State University Hospital, Copenhagen
Laboratory of Medical Immunology TA7544, Rigshospitalet, Tagensvej 20, DK-2200 Copenhagen N, DenmarkSearch for more papers by this authorJANNIE M. BEYER
Department of Rheumatology, Kong Christian den X's Gigthospital, Graasten
Search for more papers by this authorKIM KLARLUND
Department of Medicine, Slagelse Centralsygehus, Slagelse, Denmark
Search for more papers by this authorINGE H. CLEMMENSEN
Medical Department TA, State University Hospital, Copenhagen
Search for more papers by this authorBENTE K. PEDERSEN,
JANNIE M. BEYER,
KIM KLARLUND,
INGE H. CLEMMENSEN,
Corresponding Author
BENTE K. PEDERSEN
Medical Department TA, State University Hospital, Copenhagen
Laboratory of Medical Immunology TA7544, Rigshospitalet, Tagensvej 20, DK-2200 Copenhagen N, DenmarkSearch for more papers by this authorJANNIE M. BEYER
Department of Rheumatology, Kong Christian den X's Gigthospital, Graasten
Search for more papers by this authorKIM KLARLUND
Department of Medicine, Slagelse Centralsygehus, Slagelse, Denmark
Search for more papers by this authorINGE H. CLEMMENSEN
Medical Department TA, State University Hospital, Copenhagen
Search for more papers by this authorFirst published: November 1985
Abstract
Natural killer (NK) cell activity against the leukemia cell line K-562 was tested in 45 patients with rheumatoid arthritis (RA) who either had not received any remission-inducing drugs for more than 6 months or had received penicillamine for at least 6 months. Baseline NK cell activity and interferon (IF)-enhanced NK cell activity did not differ from that observed in 45 controls matched for age and sex, and neither NSAID (non steroidal anti-inflammatory drugs) nor penicillamine influenced NK cell activity. There was no correlation between NK cell activity and acute-phase reactants.
REFERENCES
- 1 Berge, R. J. M. Ten Walbeck, H. K. van & Scallekens, Rh. A.: Evaluation of the immunosuppressive effects of cyclophosphamide in patients with multiple sclerosis. Clin. Exp. Immunol. 50: 495–502, 1982.
- 2 Boyum, A.: Separation of leukocytes from blood and bone marrow. Scand. J. Clin. Lab. Invest. 21, suppl. 97, 1967.
- 3 Brunda, M. J., Herberman, R. B. & Holden, H. T.: Inhibition of murine natural killer cell activity by prostaglandins. J. Immunol. 124: 2682–2687, 1980.
- 4 Droller, M. J., Schneider, M. U. & Perlman, P.: A possible role of prostaglandins in the inhibition of natural killer cell activity and antibody-dependent cell-mediated cytotoxicity against tumor cells. Cell. Immunol. 39: 165–177, 1978.
- 5 Egan, M. L., Medelsohn, S. L., Abo, T. & Balch, C. M.: Natural killer cells in systemic lupus erythematosus. Arthritis and Rheumatism 25: 623–629, 1983.
- 6 Fauci, A. S., Dale, D. C. & Balow, J. E.: Glucocorticoid therapy: mechanisms of action and clinical considerations. Ann. Intern. Med. 84: 304, 1976.
- 7 Herberman, R. B.: Natural Killer (NK) cells and their possible roles in resistance against disease. Clin. Immunol. Rev. 1: 1–65, 1981.
- 8 Hoffman, T.: Natural killer function in systemic lupus erythematosus. Arthritis and Rheumatism 23: 30–35, 1981.
- 9 Cantell, K. & Hirronen, S.: Large-scale production of human leukocyte interferon containing 108 units per ml. Gen. Virol. 39: 541–543, 1978.
- 10 Karsch, J., Dorval, G. & Osterland, C. K.: Natural cytotoxicity in rheumatoid arthritis and systemic lupus erythematosus. Clin. Immunol. Immunopathol. 19: 437–446, 1981.
- 11 Katz, P., Zaytown, A. M., Lee, J. H., Panush, R. S. & Longley, S.: Abnormal natural killer cell activity in systemic lupus erythematosus – an intrinsic defect in the lytic event. J. Immunol. 129: 1966–1971, 1982.
- 12 Kaufman, D. B.: Natural killer augmentation in systemic lupus erythematosus via a soluble mediator derived from human lymphocytes. Arthritis and Rheumatism 25: 562–567, 1982.
- 13 Makoto, G., Kiyoaki, T., Tadao, C. & Yoshihiko, H.: Natural cell-mediated cytotoxicity in Sjögren's syndrome and rheumatoid arthritis. Arthritis and Rheumatism 24: 1274–1279, 1981.
- 14 Makoto, G., Kiyoaki, T. & Yoshihiko, H.: Natural killer cell-mediated cytotoxicity in systemic lupus erythematosus – suppression by antilymphocyte antibody. Arthritis and Rheumatism 23: 1274–1281, 1980.
- 15 Miyasaka, N., Seaman, W., Bakshi, A., Sauvezie, B., Strand, V., Pope, R. & Talal, N.: Natural killing activity in Sjögren's syndrome – an analysis of defective mechanisms. Arthritis and Rheumatism 26: 954–960, 1983.
- 16 Nagahiro, M., Ahira, T., Shogo, K. & Fulmanaro, T.: Studies of the function of natural killer-interferon system in patients with Sjögren's syndrome. Clin. Invest. 69: 581–588, 1982.
- 17 Neighbour, P. A., Grayzel, A. I. & Miller, A. E.: Endogenous and interferon-augmented natural killer cell activity of human peripheral blood mononuclear cells in vitro. Studies of patients with multiple sclerosis, systemic lupus erythematosus, or rheumatoid arthritis. Clin. Exp. Immunol. 49: 11–21, 1982.
- 18 Oshimi, K., Gonda, N., Sumiva, M. & Kano, S.: Effects of corticosteroids on natural killer cell activity in systemic lupus erythematosus. Clin. Exp. Immunol. 40: 83, 1980.
- 19 Oshimi, K., Suniya, M., Gonda, N., Kano, S. & Tahaku, F.: Natural killer cells activity in systemic lupus erythematosus. Lancet ii: 1023, 1979.
- 20 Parillo, J. E. & Fauci, A. S.: Comparison of the effector cells in human spontaneous cellular cytotoxicity and antibody dependent cellular cytotoxicity: Differential sensitivity of effector cells to in vivo and in vitro corticosteroids. Scand. J. Immunol. 8: 99–107, 1978.
- 21 Pedersen, B. K., Beyer, J. M., Rasmussen, A., Klarlund, K., Hørslev-Petersen, K., Pedersen, B. N. & Helin, P.: Azathioprine as single drug in the treatment of rheumatoid arthritis induces complete suppression of natural killer cell activity.. Acta path. microbiol. immunol. scand. Sect. C, 92: 221–225, 1984.
- 22 Pedersen, B. K., Beyer, J. M., Rasmussen, A., Klarlund, K., Pedersen, B. N. & Helin, P.: Methylprednisolone pulse therapy induced fall in natural killer cell activity in rheumatoid arthritis.. Acta path. microbiol. immunol. scand. Sect. C, 92: 319–323, 1984.
- 23 Penschow, J. & Mackay, I. R.: NK and K cell activity of human blood; differences according to sex, age and disease. Ann. Rheum. Dis. 39: 82–86, 1980.
- 24 Sibbitt, W. L., Froelich, C. J. & Bankjurst, A. D.: Abnormal interferon modulation of natural cytotoxicity in systemic lupus erythematosus. Arthritis and Rheumatism 26: 1452–1459, 1983.
- 25 Strannegård, O., Hermodsson, S. & Westberg, G.: Interferon and natural killer cells in systemic lupus erythematosus. Clin. Exp. Immunol. 50: 246–252, 1982.
- 26 Wright, J. K., Hughes, P. & Rowell, N. R.: Lymphocyte cytotoxicity in systemic sclerosis: no increase in short-term culture with established human cells lines. Ann. Rheum. Dis. 41: 414–416, 1982.
- 27 Wright, J. K., Hughes, P. & Rowell, N. R.: Spontaneous lymphocyte mediated (NK cell) cytotoxicity in systemic sclerosis: a comparison with antibody-dependent lymphocyte (K cell) cytotoxicity. Ann. Rheum. Dis. 41: 409–413, 1982.
