Volume 76, Issue 4 pp. 240-244

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The Promoting Action of Magnesium Lithospermate B on the Kinin-Prostaglandin E₂ System in the Kidney

Hae Young Chung,

Hae Young Chung

College of Pharmacy, Pusan National University, Gum Jung-Ku, Pusan, 609-735, Korea, Japan

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Jung Sun Kim,

Jung Sun Kim

College of Pharmacy, Pusan National University, Gum Jung-Ku, Pusan, 609-735, Korea, Japan

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Han Young Chung,

Han Young Chung

College of Pharmacy, Pusan National University, Gum Jung-Ku, Pusan, 609-735, Korea, Japan

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Takako Yokozawa,

Takako Yokozawa

Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-01, Japan

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Hikokichi Oura,

Hikokichi Oura

Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-01, Japan

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Hae Young Chung,

Hae Young Chung

College of Pharmacy, Pusan National University, Gum Jung-Ku, Pusan, 609-735, Korea, Japan

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Jung Sun Kim,

Jung Sun Kim

College of Pharmacy, Pusan National University, Gum Jung-Ku, Pusan, 609-735, Korea, Japan

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Han Young Chung,

Han Young Chung

College of Pharmacy, Pusan National University, Gum Jung-Ku, Pusan, 609-735, Korea, Japan

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Takako Yokozawa,

Takako Yokozawa

Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-01, Japan

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Hikokichi Oura,

Hikokichi Oura

Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-01, Japan

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First published: April 1995

https://doi.org/10.1111/j.1600-0773.1995.tb00136.x

Citations: 4

Author for correspondence: Takako Yokozawa, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, Japan (fax +81-0764-34-4656).

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Abstract

Abstract: The effect of magnesium lithospermate B purified from Salviae Miltiorrhizae Radix on the kinin-prostaglandin E₂ system was investigated using kidney slices and isolated kidney microsomes. Magnesium lithospermate B markedly increased the amount of thiobarbituric acid-reactive substances produced by incubation of arachidonic acid in renal slices. Enhancement of arachidonic acid-mediated oxygenation of 1, 3-diphenylisobenzofuran was also observed in renal microsomes from rats treated with magnesium lithospermate B, indicating an increase of prostaglandin biosynthesis. Furthermore, magnesium lithospermate B significantly increased the synthesis of prostaglandin E₂ in renal slices, but the magnesium lithospermate B-mediated response was blunted with kinin antagonist. On the basis of the above results, it is apparent that magnesium lithospermate B exerts an influence on the prostaglandin system via kinin receptors.

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Volume76, Issue4

April 1995

Pages 240-244

The Promoting Action of Magnesium Lithospermate B on the Kinin-Prostaglandin E₂ System in the Kidney

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