Acta Pharmacologica et Toxicologica

Volume 25, Issue 1 pp. 127-140

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Actions of Prenylamine (Segontin ®) on the Cardiovascular System

Hopé Obianwu, 

Hopé Obianwu

Department of Pharmacology, University of Göteborg, Sweden

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Hopé Obianwu, 

Hopé Obianwu

Department of Pharmacology, University of Göteborg, Sweden

Search for more papers by this author

First published: March 1967

https://doi.org/10.1111/j.1600-0773.1967.tb01417.x

Citations: 9

References

• Abboud, F. M. & J. W. Eckstein: Effect of small doses of reserpine on vascular responses to tyramine and norepinephrine in man. Circulation 1964, 29, 219–223.
  10.1161/01.CIR.29.2.219

  CAS PubMed Web of Science® Google Scholar
• Abrahamsen, A. M.: Cardiac catheterization studies following injection of Synadrin^R: Acta Medica Scand. 1963, 174, 265–269.
  10.1111/j.0954-6820.1963.tb07922.x

  CAS PubMed Web of Science® Google Scholar
• Andén, N.-E., H. Corrodi, M. Ettles & E. Gustafsson: Selective uptake of some catecholamines by the isolated heart and its inhibition by cocaine and phenoxybenzamine. Acta pharmacol. et toxicol. 1964, 21, 247–259.
  10.1111/j.1600-0773.1964.tb01789.x

  CAS PubMed Web of Science® Google Scholar
• Alleyne, G. A. O., C. J. Dickinson, A. C. Dornhorst, R. M. Fulton, K. G. Green, I. D. Hill, P. Hurst, D. R. Lawrence, T. Pilkington, B. M. C. Prichard, B. Robinson & M. L. Rosenhein: Effect of pronethalol in angina pectoris. Brit. Med. J. 1963, 2, 1226–1229.
  10.1136/bmj.2.5367.1226

  CAS PubMed Google Scholar
• Baumgarten, A.: The clinical effects of a new anti-anginal agent, prenylamine (Segontin). Med. J. Aus. 1962, 49, 429–431.
  PubMed Google Scholar
• Böhm, C., M. Schlepper & E. Witzleb: Eine neue coronargefässerweiternde Substanz. Dtsch. med. Wschr. 1960, 85, 1405.
  10.1055/s-0028-1112595

  Web of Science® Google Scholar
• Burn, J. H. & M. J. Rand: The action of sympathomimetic amines in animals treated wi reserpine. J. Physiol. (Lond.) 1958, 144, 314–336.
  10.1113/jphysiol.1958.sp006104

  CAS PubMed Web of Science® Google Scholar
• Butterworth, K. R.: The β-adrenergic blocking and pressor actions of isoprenaline in the cat. Brit. J. Pharmacol. 1963, 21, 378–392.
  10.1111/j.1476-5381.1963.tb01536.x

  CAS PubMed Web of Science® Google Scholar
• Carlsson, A. & B. Waldeck: Inhibition of ³H-metaraminol uptake by antidepressive and related agents. J. Pharm. Pharmacol. 1965, 17, 243–244.
  10.1111/j.2042-7158.1965.tb07653.x

  CAS PubMed Web of Science® Google Scholar
• Carlsson, A. & B. Waldeck: Release of ³H-metaraminol by different mechanisms. Acta physiol. scand. 1966, 67, 471–480.
  10.1111/j.1748-1716.1966.tb03333.x

  CAS PubMed Web of Science® Google Scholar
• Carlsson, A., E. Rosengren, Å. Bertler & J. Nilsson: Effect of reserpine on the metabolism of catecholamines. In: Psychotropic drugs. Ed. by S. Garattini and V. Ghetti. Elsevier publ. Co., Amsterdam 1957, p. 363.
  Google Scholar
• Dornhorst, A. C. & B. F. Robinson: Clinical pharmacology of a beta-adrenergic blocking agent (Nethalide). Lancet 1962, II, 314–316.
  10.1016/S0140-6736(62)90104-6

  CAS Google Scholar
• Gillespie, J. S. & S. M. Kirpekar: The inactivation of infused NA by the cat spleen. J. Physiol. (Lond.) 1965, 176, 205–227.
  10.1113/jphysiol.1965.sp007545

  CAS PubMed Web of Science® Google Scholar
• Hamer, J., T. Grandjean, L. Melendez & G. W. Sowton: Effect of propranolol (inderal) in angina pectoris. Brit. Med. J. 1964, 2, 721.
  10.1136/bmj.2.5411.720

  CAS Google Scholar
• Hertting, G.: The fate of ³H-isoproterenol in rat. Biochem. pharmacol 1964, 13, 1119–1128.
  10.1016/0006-2952(64)90112-1

  CAS PubMed Web of Science® Google Scholar
• Iversen, L. L. & L. G. Whitby: Retention of injected catecholamines by the mouse. Brit. J. Pharmacol. 1962, 19, 355–364.
  10.1111/j.1476-5381.1962.tb01199.x

  CAS PubMed Web of Science® Google Scholar
• Koechsiek, K., H. J. Bretschneider & F. Scheler: Vergleichende experimentelle Untersuchungen über die Coronargefässerweiternde Wirkung von phenyl-propyl-diphenyl-propylamin. Arzneimittel. Forsch. 1960, 10, 576.
  Google Scholar
• Kuschke, H. J., H. Idris & F. Eckmann: Zum Wirkungsmechanismus des phenylpropyl-diphenylpropylamin (Segontin) beim Menschen. Klin. Wochenschrift 1965, 43, 167.
  10.1007/BF01879186

  Web of Science® Google Scholar
• Lindner, E.: Phenyl-propyl-diphenyl-propylamine, eine neue Substanz mit Coronarge-fässerweiternder Wirkung. Arzneimittel. Forsch. 1960, 10, 569.
  CAS PubMed Web of Science® Google Scholar
• Lindner, E.: Die Beeinflussung der Herzdynamik durch β-Sympathicolytisch Wirksame Substanzen. Verhandlungen der Deutschen Gesellschaft für innere. Med. 1964, 70, 201–205.
  Google Scholar
• Maxwell, R. A., A. J. Plummer, S. D. Ross, A. I. Daniel & F. Schneider: Factors affecting the blood pressure response of mammals to the ganglionic blocking agent, chlorisondamine chloride. J. Pharmacol. 1958, 123, 238–246.
  CAS PubMed Web of Science® Google Scholar
• Mackenna, B. R.: Uptake of catecholamines by hearts of rabbits treated with Segontin. Acta physiol. scand. 1965, 63, 413–422.
  10.1111/j.1748-1716.1965.tb04083.x

  CAS PubMed Web of Science® Google Scholar
• Maickel, R. P., M. A. Beaven & B. B. Brodie: Implications of uptake and storage of norepinephrine by sympathetic nerve endings. Life Sci. 1963, 12, 953–958.
  10.1016/0024-3205(63)90064-X

  PubMed Google Scholar
• McEwens, L. M.: The effect on the isolated rabbit heart of vagal stimulation and its modification by cocain, hexamethonium and oubain. J. Physiol. (Lond.) 1956, 131, 678–689.
  10.1113/jphysiol.1956.sp005493

  PubMed Web of Science® Google Scholar
• Obainwu, H. O.: The effect of prenylamine on the amine levels of brain, heart adrenal medulla in rats. Acta pharmacol. et toxicol. 1965, 23, 383–390.
  10.1111/j.1600-0773.1965.tb00362.x

  Google Scholar
• Obianwu, H. O., Sympathetic and receptor blockade after prenylamine (Segontin). Acta pharmacol. et toxicol. 1967, 25, 141–154.
  10.1111/j.1600-0773.1967.tb01418.x

  CAS Web of Science® Google Scholar
• Popovic, V. & P. Popovic: Permanent cannulation of aorta and vena cava in rats and ground squirrels. J. Appl. Physiol. 1960, 15, 727–728.
  PubMed Web of Science® Google Scholar
• Raab, W.: Key position of catecholamine in functional and degenerative cardiovascular pathology. Amer. J. Cardiol. 1960, 5, 571.
  10.1016/0002-9149(60)90121-1

  CAS PubMed Web of Science® Google Scholar
• Raab, W.: Sympathogenic biochemical trigger mechanism of angina pectoris. Amer. J. Cardiol. 1962, 9, 576–590.
  10.1016/0002-9149(62)90077-2

  CAS PubMed Web of Science® Google Scholar
• Sekiya, A. & E. M. Vaughan Williams: Central and peripheral actions of pronethalol. Brit. J. Pharmacol. 1965, 24, 307–318.
  10.1111/j.1476-5381.1965.tb01717.x

  CAS PubMed Web of Science® Google Scholar

Citing Literature

Volume25, Issue1

March 1967

Pages 127-140

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