Lipid-laden perisinusoidal cells in patients with acquired immunodeficiency syndrome
Michel Dupon
Laboratoire d'Anatomie Pathologique et Service des Maladies Infectieuses, Hôpital Pellegrin, CHU de Bordeaux, et Laboratoire des Interactions Cellulaires, Université de Bordeaux II, Bordeaux, France
Search for more papers by this authorTanios Kosaifi
Laboratoire d'Anatomie Pathologique et Service des Maladies Infectieuses, Hôpital Pellegrin, CHU de Bordeaux, et Laboratoire des Interactions Cellulaires, Université de Bordeaux II, Bordeaux, France
Search for more papers by this authorBrigitte Le Bail
Laboratoire d'Anatomie Pathologique et Service des Maladies Infectieuses, Hôpital Pellegrin, CHU de Bordeaux, et Laboratoire des Interactions Cellulaires, Université de Bordeaux II, Bordeaux, France
Search for more papers by this authorYves Lacut
Laboratoire d'Anatomie Pathologique et Service des Maladies Infectieuses, Hôpital Pellegrin, CHU de Bordeaux, et Laboratoire des Interactions Cellulaires, Université de Bordeaux II, Bordeaux, France
Search for more papers by this authorCharles Balabaud
Laboratoire d'Anatomie Pathologique et Service des Maladies Infectieuses, Hôpital Pellegrin, CHU de Bordeaux, et Laboratoire des Interactions Cellulaires, Université de Bordeaux II, Bordeaux, France
Search for more papers by this authorCorresponding Author
Paulette Bioulac-Sage
Laboratoire d'Anatomie Pathologique et Service des Maladies Infectieuses, Hôpital Pellegrin, CHU de Bordeaux, et Laboratoire des Interactions Cellulaires, Université de Bordeaux II, Bordeaux, France
Laboratoire des Interactions Cellulaires Université de Bourdeaux II 146, rue Léo-Saignat 33076-Bordeaux CEDEX FranceSearch for more papers by this authorMichel Dupon
Laboratoire d'Anatomie Pathologique et Service des Maladies Infectieuses, Hôpital Pellegrin, CHU de Bordeaux, et Laboratoire des Interactions Cellulaires, Université de Bordeaux II, Bordeaux, France
Search for more papers by this authorTanios Kosaifi
Laboratoire d'Anatomie Pathologique et Service des Maladies Infectieuses, Hôpital Pellegrin, CHU de Bordeaux, et Laboratoire des Interactions Cellulaires, Université de Bordeaux II, Bordeaux, France
Search for more papers by this authorBrigitte Le Bail
Laboratoire d'Anatomie Pathologique et Service des Maladies Infectieuses, Hôpital Pellegrin, CHU de Bordeaux, et Laboratoire des Interactions Cellulaires, Université de Bordeaux II, Bordeaux, France
Search for more papers by this authorYves Lacut
Laboratoire d'Anatomie Pathologique et Service des Maladies Infectieuses, Hôpital Pellegrin, CHU de Bordeaux, et Laboratoire des Interactions Cellulaires, Université de Bordeaux II, Bordeaux, France
Search for more papers by this authorCharles Balabaud
Laboratoire d'Anatomie Pathologique et Service des Maladies Infectieuses, Hôpital Pellegrin, CHU de Bordeaux, et Laboratoire des Interactions Cellulaires, Université de Bordeaux II, Bordeaux, France
Search for more papers by this authorCorresponding Author
Paulette Bioulac-Sage
Laboratoire d'Anatomie Pathologique et Service des Maladies Infectieuses, Hôpital Pellegrin, CHU de Bordeaux, et Laboratoire des Interactions Cellulaires, Université de Bordeaux II, Bordeaux, France
Laboratoire des Interactions Cellulaires Université de Bourdeaux II 146, rue Léo-Saignat 33076-Bordeaux CEDEX FranceSearch for more papers by this authorAbstract
ABSTRACT— Liver biopsies were taken from ten AIDS patients. Liver architecture was normal in all patients. On 1-μm-thick sections stained with toluidine blue, all ten cases showed lipid overload of perisinusoidal cells (1 massive, 5 moderate and 4 mild) compared to 2/8 in control patients, who had mild lipid overload. Other sinusoidal abnormalities such as hypertrophy of Kupffer cells and inclusions in endothelial cells were also noticed. Some hepatocytes presented evidence of cellular damage. Perisinusoidal cell lipid overload was not associated with hypervitaminosis A. We hypothesize that the abnormal accumulation of lipids in perisinusoidal cells (non-induced by hypervitaminosis A) in patients with AIDS could be due to defective transport of vitamin A from perisinusoidal cells to hepatocytes, and/or from hepatocytes to blood. The cause of the defect is unknown. Since lipid overload occurs in many and diverse conditions (diabetes, cholestasis, primary biliary cirrhosis, etc.), it seems reasonable to propose that the defect is non-specific and limited to functional or structural damage of the liver whether induced by drugs, liver or systemic diseases.
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