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What can we learn about human immunodeficiency virus infection from a study of lymphocytic choriomeningitis virus?
Paul Klenerman,
Rolf M. Zinkernagel,
Paul Klenerman
Institute for Experimental Immunology, University Hospital, Zurich, Switzerland.
Search for more papers by this authorCorresponding Author
Rolf M. Zinkernagel
Institute for Experimental Immunology, University Hospital, Zurich, Switzerland.
Rolf M. Zinkernagel Institute for Experimental Immunology Schmelzbergstrasse 12 8091 Zurich Switzerland Fax: 41 1 255 4420 e mail: [email protected]Search for more papers by this authorPaul Klenerman,
Rolf M. Zinkernagel,
Paul Klenerman
Institute for Experimental Immunology, University Hospital, Zurich, Switzerland.
Search for more papers by this authorCorresponding Author
Rolf M. Zinkernagel
Institute for Experimental Immunology, University Hospital, Zurich, Switzerland.
Rolf M. Zinkernagel Institute for Experimental Immunology Schmelzbergstrasse 12 8091 Zurich Switzerland Fax: 41 1 255 4420 e mail: [email protected]Search for more papers by this authorSummary
The role of cytotoxic T lymphocytes (CTL) in human immunodeficiency virus (HIV) infection remains elusive. Since the discover) 10 years ago of high levels of specific CTL in this disease, same have argued that they play an important role in virus control, minis that they drive disease progression through destruction of T helper cells, and others st ill that they play no obvious role at all. By contrast, the central role of CTL in murine lymphocytic choriomeningitis virus (LCMV) infection has been very clearly worked out through the use of in vivo depletion and adoptive transfer experiments, as well as knockout and transgenic mice. To interpret the possible roles for CTL in HIV, we have therefore made a comparison between what is known about CTL and their interaction with virus-infected cells in these two infections. This illustrates a potential critical role for these cells in both control of HIV replication and immune-mediated pathology, but one that is highly dependent on virus dose, distribution and dynamics.
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