Absence of the AKT1 pleckstrin homology domain mutation in Japanese gastrointestinal and liver cancer patients
Yuqin Li
Departments of Gastroenterology
Department of Gastroenterology, the First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Search for more papers by this authorCorresponding Author
Yasuo Tanaka
Departments of Gastroenterology
Clinical Drug Evaluation, Graduate School of Medicine, University of Tokyo, Tokyo
Yasuo Tanaka, Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. [email protected]Search for more papers by this authorMotohisa Tada
Departments of Gastroenterology
Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba
Search for more papers by this authorFumihiko Kanai
Departments of Gastroenterology
Clinical Drug Evaluation, Graduate School of Medicine, University of Tokyo, Tokyo
Search for more papers by this authorTeiji Motojima
Abdominal Surgery, Motojima General Hospital, Gumma, Japan
Search for more papers by this authorOsamu Yokosuka
Department of Gastroenterology, the First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Search for more papers by this authorYuqin Li
Departments of Gastroenterology
Department of Gastroenterology, the First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Search for more papers by this authorCorresponding Author
Yasuo Tanaka
Departments of Gastroenterology
Clinical Drug Evaluation, Graduate School of Medicine, University of Tokyo, Tokyo
Yasuo Tanaka, Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. [email protected]Search for more papers by this authorMotohisa Tada
Departments of Gastroenterology
Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba
Search for more papers by this authorFumihiko Kanai
Departments of Gastroenterology
Clinical Drug Evaluation, Graduate School of Medicine, University of Tokyo, Tokyo
Search for more papers by this authorTeiji Motojima
Abdominal Surgery, Motojima General Hospital, Gumma, Japan
Search for more papers by this authorOsamu Yokosuka
Department of Gastroenterology, the First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Search for more papers by this authorReceived 26 December 2007.
Accepted 13 March 2008.

REFERENCES
- 1 Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002; 296: 1655–7.
- 2 Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2: 489–501.
- 3 Parsons DW, Wang TL, Samuels Y, Bardelli A, Cummins JM, DeLong L, et al. Colorectal cancer: mutations in a signalling pathway. Nature 2005; 436: 792.
- 4 Carpten JD, Faber AL, Horn C, Donoho GP, Briggs SL, Robbins CM, et al. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 2007; 448: 439–44.
- 5 Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004; 304: 1497–500.
- 6 Guleng B, Tateishi K, Ohta M, Asaoka Y, Jazag A, Lin LJ, et al. Smoothened gene mutations found in digestive cancer have no aberrant Hedgehog signaling activity. J Gastroenterol 2006; 41: 1238–9.
- 7 Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, et al. Patterns of somatic mutation in human cancer genomes. Nature 2007; 446: 153–8.
- 8 Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, et al. The consensus coding sequences of human breast and colorectal cancers. Science 2006; 314: 268–74.