Changes of local cerebral blood flow concomitant to lead-exposure in adult rabbits

Ü. Linnamägi,

Ü. Linnamägi

Department of Neurology and Neurosurgery, University of Tartu, 2., Ludvig Puusepp St., EE2400 Tartu, Estonia

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A-E. Kaasik,

A-E. Kaasik

Department of Neurology and Neurosurgery, University of Tartu, 2., Ludvig Puusepp St., EE2400 Tartu, Estonia

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Ü. Linnamägi,

Ü. Linnamägi

Department of Neurology and Neurosurgery, University of Tartu, 2., Ludvig Puusepp St., EE2400 Tartu, Estonia

Search for more papers by this author

A-E. Kaasik,

A-E. Kaasik

Department of Neurology and Neurosurgery, University of Tartu, 2., Ludvig Puusepp St., EE2400 Tartu, Estonia

Search for more papers by this author

First published: December 1995

https://doi.org/10.1111/j.1600-0404.1995.tb00486.x

Citations: 5

Linnamägi Ü, Kaasik A-E. Changes of local cerebral blood flow concomitant to lead-exposure in adult rabbits.

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Abstract

Lead is considered a pathogenic factor of atherosclerosis and arterial hypertension, which are main risk factors of cerebrovascular disease. The brain microvasculature preferentially accumulates lead and its function is sensitive to its toxic effect. Influence of inorganic lead-exposure (20 mg/kg - I group, 40 mg/kg II group) for 10 days on local cerebral blood flow (1CBF) in hypothalamus (HYP) and cerebral cortex (CTX) of rabbits was studied by means of the hydrogen clearance method. Corresponding results were compared to sham operated group (III group). During lead-exposure 1CBF was reduced in both investigated regions. The reduction of 1CBF in HYP was reduced in both investigated regions. The reduction of 1CBF in HYP was 12.9% (P<0.05) in I and 19.9% (P < 0.001) in II group; corresponding changes in CTX were - 16.9 % (statistically non-significant - N) in I and 1.4% (NS) in II group. Present finding suggest that inorganic lead induces cerebral microvascular dysfunction with following changes in 1CBF. These alteration have a biphasic character Although these disturbances reveal a tendency towards normalization, it is possible to presume that higher concentrations of ingested lead cause more severe injury to endothelium of brain microvasculature.

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