Lectin binding to Renaut bodies
Corresponding Author
M. Nagao
Department of Neurology, Tokyo Metropolitan Neurological Hospital
Masahiro Nagao, Department of Neurology, Tokyo Metropolitan Neurological Hospital, 2-6-1, Musashidai, Fuchu, Tokyo 183, JapanSearch for more papers by this authorCorresponding Author
M. Nagao
Department of Neurology, Tokyo Metropolitan Neurological Hospital
Masahiro Nagao, Department of Neurology, Tokyo Metropolitan Neurological Hospital, 2-6-1, Musashidai, Fuchu, Tokyo 183, JapanSearch for more papers by this authorAbstract
Localization of sugar residues of Renaut bodies in human sural nerves was studied using lectin histochemistry. Lens culinaris specific to mannose and Triticum vulgaris specific to glcNAc bound to the capsular and core portions of Renaut bodies strongly. Arachis hypogaea specific to galb(1-3)galNAc and Ulex europaeus I specific to L-fucose bound to Renaut bodies granularly. Lectins specific to galactose or terminal galNAc bound to nowhere. The perineurium showed similar lectin binding to Renaut bodies. Our result suggests that Renaut bodies are rich in mannose and glcNAc. Renaut bodies may be originated from the perineurium.
References
- 1 Renaut J. Recherche sur quelques points particuliers d'histologie des nerfs. Arch Physiol 1881: 8: 180–190.
- 2 Dyck PJ, Llambert EH. Polyneuropathy associated with hypothyroidism. J Neuropathol Exp Neurol 1970: 29: 631–658.
- 3 Duncan ID, Schneider RK, Hammang JP. Subclinical entrapment neuropathy of the equine suprascapular nerve. Acta Neuropathol 1987: 74: 53–61.
- 4 Jefferson D, Neary D, Eames RA. Renaut body distribution at sites of human peripheral nerve entrapment. J Neurol Sci 1981: 24: 283–298.
- 5 Ortman AJ, Sahenk Z, Mendell JR. The experimental production of Renaut bodies. J Neurol Sci 1983: 62: 233–241.
- 6 Bergouignan F-X, Vital C. Occurrence of Renaut bodies in a peripheral nerve. Arch Pathol Lab Med 1984: 108: 330–333.
- 7 Asbury AK. Renaut bodies: a forgotten endoneurial structure. J Neuropathol Exp Neurol 1973: 32: 334–343.
- 8 Drickemer K. Two distinct classes of carbohydrate-recognition domaine in animal lectins. J Biol Cheni 1988: 263: 9557–9560.
- 9 Edelman GM. Modulation of cell adhesion during induction, histogenesis, and perinatal development of the nervous system. Ann Rev Neurosci 1984: 7: 339–377.
- 10 Dodd J, Solter D, Jessell TM. Monoclonal antibodies against carbohydrate differentiation antigens identify subsets of primary sensory neurons. Nature 1984: 311: 469–472.
- 11 Damajanov I. Biology of disease: lectin cytochemistry and histochemistry. Lab Invest 1987: 57: 5–20.
- 12 Colaco CALS, Harrington CR. Glycation: a pathological modification in neuropathies?: a hypothesis. Neurore-port 1994: 5: 859–861.
- 13 Spicer SS, Schulte BA. Diversity of cell glycoconju-gates shown histochemically: a perspective. J Histochem Cytochem 1992: 40: 1–38.
- 14 Fischer J, Csillik B. Lectin binding: a genuine marker for transganglionic regulation of human primary sensory neurons. Neurosci Lett 1985: 54: 263–267.
- 15 Naegele JR, Kats LC. Cell surface molecules containing N-acetylgalactosamine are associated with basket cells and neurogliaform cells in cat visual cortex. J Neurosci 1990: 10: 540–557.
- 16 Nagao M, Kamo H, Akicuchi I. Kimura J. Soybean agglutinin binds commonly to dorsal root ganglion, vascular endothelium and microglia in human spinal cord. Neurosci Lett 1992: 142: 131–134.
- 17 Nagao M, Oka N, Kamo H, Akiguchi I, Kimura J. Ulex europaeus I and glycine max bind to the human olfactory bulb. Neurosci Lett 1993: 164: 221–224.
- 18 Nagao M, Oka N, Kamo H, Akiguchi I, Kimura J. Differential localization of lectin binding sites and neuropeptides in human dorsal root ganglia. Histochemistry 1994: 102: 279–286.
- 19 Nakagawa F, Shulte BA Spicer SS. Selective Cytochemical demonstration of glycoconjugate-containing terminal N-acetylgalactosamine on some brain neurons. J Comp Neurol 1986: 243: 280–290.
- 20 Szumanska G, Vorbrodt AW, Mandybur TI. Wisniewski HM. Lectin histochemistry of plaques and tangles in Alzheimer's disease. Acta Neuropathol 1987: 73: 1–11.
- 21 Goebel HH, Shin YS, Gullotta F, Yokota T, Alroy J, Voit T, Haller P, Schulz A. Adult polyglucosan body myopathy. J Neuropathol Exp Neurol 1992: 51: 24–35.
- 22 Nagao M, Nakamura M, Oka N, Akiguchi I. Kimura J. Abnormal glycosylation of motor neurons with N-acetyl-D-galactosamine in a case of subacute motor neu-ronopathy associated with lymphoma. J Neurol 1994: 241: 372–375.
- 23 Weis J, Alexianou ME, Heide G, Schroder JM. Renaut bodies contain elastic fiber components. J Neuropathol Exp Neurol 1993: 52: 444–451.
- 24 Tsang WY, Chan JK, Chow LT, Tse CC. Perineurionia: an uncommon soft tissue neoplasm distinct from localized hypertrophic neuropathy and neurofibroma. Am J Surg Pathol 1992: 16: 756–763.
- 25 Hirose T, Hasegawa T, Kudo E, Seki K, Sano T, Hizawa K. Malignant peripheral nerve sheath tumors: an immunohistochemical study in relation to ultrastructural features. Hum Pathol 1992: 23: 865–870.