Full Access
Increased 2-deoxyglucose uptake in hippocampus, globus pallidus and substantia nigra after cerebral ischemia
N. H. Diemer M.D.,
E. Siemkowicz,
Corresponding Author
N. H. Diemer M.D.
Institute of Neuropathology, University of Copenhagen and the Anaesthesia Department, Hvidovre University Hospital, Denmark
Institute of Neuropathology 11, Frederik V's vej DK-2100 Copenhagen Ø DenmarkSearch for more papers by this authorE. Siemkowicz
Institute of Neuropathology, University of Copenhagen and the Anaesthesia Department, Hvidovre University Hospital, Denmark
Search for more papers by this authorN. H. Diemer M.D.,
E. Siemkowicz,
Corresponding Author
N. H. Diemer M.D.
Institute of Neuropathology, University of Copenhagen and the Anaesthesia Department, Hvidovre University Hospital, Denmark
Institute of Neuropathology 11, Frederik V's vej DK-2100 Copenhagen Ø DenmarkSearch for more papers by this authorE. Siemkowicz
Institute of Neuropathology, University of Copenhagen and the Anaesthesia Department, Hvidovre University Hospital, Denmark
Search for more papers by this authorAbstract
Ten minutes of complete cerebral ischemia in the rat results in a short period of increased 14C-2-deoxyglucose uptake in hippocampus, globus pallidus and substantia nigra, regions which selectively develop ischemic nerve cell changes, possibly as a result of damage to a transmitter system.
References
- Blennow, G., J. B. Brierley, B. S. Meldrum & B. K. Siesjö (1978): Epileptic brain damage. The role of systemic factors that modify cerebral energy metabolism. Brain 101, 687–700.
- Brierley, J. B. (1976): Cerebral hypoxia. In Greenfields Neuropathology ( W Black-wood & J. A. N. Corsellis) pp. 43–85, Arnold, London .
- Collins, R. D. (1978): Use of cortical circuits during focal penicillin seizures: an auto-radiographic study with (14C) deoxyglucose. Brain Research 150, 487–501.
- Diemer, N. H. & E. Siemkowicz (1978): The influence of different blood-glucose levels on the brain damage in rats after cerebral ischemia. Neuropath. Appl. Neurobiol. 4, 236.
- Diemer, N. H. & E. Siemkowicz (1979): Regional glucose metabolism in the rat brain after ischemia. Neuropath. Appl. Neurobiol. 5, 83–84.
- Divac, I. & N. H. Diemer (1979): Prefrontal system in the rat visualized by means of labelled deoxyglucose. Evidence for functional heterogenity of the neostriatum. J. Comp. Neurol. In press.
- Fieschi, C., O. Sakurada & L. Sokoloff (1978): Local cerebral glucose utilization during resolution of embolic experimental ischemia. In: Pathology of Cerebrospinal Microcirculation ( J Cervos-Navarro, E. Betz, G. Ebhardt, R. Ferzt & R. Wullenweber) 20, pp. 223–230. Raven Press, N.Y .
- Ginsberg, M. D., M. Reivich, A. Giandomenico & J. H. Greenberg (1977): Local glucose utilization in acute focal cerebral ischemia: Local dysmetabolism and diaschisis. Neurol. 27, 1042–1048.
- Ito, U., M. Spatz, J. T. Walker Jr. & I. Klatzo (1975): Experimental cerebral ischemia in Mongolian gerbils. Acta Neuropath. 32, 209–223.
- Kakari, S., K. Nishimoto, J. T. Walker Jr. & M. Spatz (1977): Effects of ischemia on regional glucose metabolism in the gerbil. J. Neuropath. Exp. Neurol. 36, 608.
- Myers, R. E. & S. Yamaguchi (1977): Nervous system effects of cardiac arrest in monkeys. Arch. Neurol. 34, 65–77.
- Nishimoto, K., M. Wolman, M. Spatz & I. Klatzo (1978): Pathophysiologic correlations in the blood-brain barrier damage due to air metabolism. In: Pathology of Cerebrospinal Microcirculation ( J Cervos-Navarro, E. Betz, G. Ebhardt, R. Ferzt & R. Wullenweber) 20, pp. 237–244. Raven Press, N.Y .
- Plum, F., A. Gjedde & F. E. Samson (1976): Neuroanatomical functional mapping by the radioactive 2-deoxy-D-glucose method. Neuroscience Research Program Bulletin 14/4, 457–518.
- Schwartz, W. J. & F. R. Sharp (1978): Autoradiographic maps of regional brain glucose consumption in resting, awake rats using (14C)-2-deoxyglucose. J. Comp. Neurol. 177, 360–385.
- Siemkowicz, E. & A. Gjedde (1979): Post-ischemic coma in the rat: Effect of different pre-ischemic blood glucose levels on cerebral metabolic recovery after ischemia. Acta Physiol. Scandinav. In press.
- Siemkowicz, E. & A. J. Hansen (1978): Clinical restitution following cerebral ischemia in hypo-, normo- and hyperglycemic rats. Acta Neurol. Scandinav. 58, 1–8.
- Siemkowicz, E., &, N. H. Diemer: 3H- and 14C-2-deoxyglucose autoradiographical determination of the glucose metabolism after cerebral ischemia in normo-, hypo- and hyperglycemic rats. To be published.
- Sokoloff, L., M. Reivich, C. Kennedy, M. H Des Rosiers, C. S. Patlak, K. D. Pettigrew, O. Sakurada & M. Shinohara (1977): The 14C-deoxyglucose method for the measurement of focal cerebral glucose utilization: Theory, procedure aand normal values in the conscious and anesthetized albino rat. J. Neurochem. 28, 897–916.
- Sokoloff, L. (1979): The 2-deoxyglucose method: Four years later. In: Cerebral Blood Flow and Metabolism (eds. H. Nagai & Y. Tazaki). Acta Neurol. Scand. 60, Suppl. 72, 640–649.
