Telocytes in the human kidney cortex
Guisheng Qi
Department of Urology, Bucharest, Romania
Shanghai Key Lab of Organ Transplantation, Bucharest, Romania
These authors have equal contribution to this work.Search for more papers by this authorMiao Lin
Department of Urology, Bucharest, Romania
Shanghai Key Lab of Organ Transplantation, Bucharest, Romania
These authors have equal contribution to this work.Search for more papers by this authorMing Xu
Department of Urology, Bucharest, Romania
Shanghai Key Lab of Organ Transplantation, Bucharest, Romania
Search for more papers by this authorC. G. Manole
Department of Cellular ad Molecular Medicine, University of Medicine, Bucharest & National Institute of Pathology, Bucharest, Romania
Search for more papers by this authorXiangdong Wang
Biomedical Research Center, Fudan University Zhongshan Hospital, Shanghai, China
Search for more papers by this authorCorresponding Author
Tongyu Zhu
Department of Urology, Bucharest, Romania
Shanghai Key Lab of Organ Transplantation, Bucharest, Romania
Correspondence to: Tongyu ZHU, MD, PhD, Prof, Department of Urology, Fudan University Zhongshan Hospital, Shanghai, China.
Tel.: +86 21 64041990 (ext. 5468)
Fax: +86 21 64037269
E-mail: [email protected]
Search for more papers by this authorGuisheng Qi
Department of Urology, Bucharest, Romania
Shanghai Key Lab of Organ Transplantation, Bucharest, Romania
These authors have equal contribution to this work.Search for more papers by this authorMiao Lin
Department of Urology, Bucharest, Romania
Shanghai Key Lab of Organ Transplantation, Bucharest, Romania
These authors have equal contribution to this work.Search for more papers by this authorMing Xu
Department of Urology, Bucharest, Romania
Shanghai Key Lab of Organ Transplantation, Bucharest, Romania
Search for more papers by this authorC. G. Manole
Department of Cellular ad Molecular Medicine, University of Medicine, Bucharest & National Institute of Pathology, Bucharest, Romania
Search for more papers by this authorXiangdong Wang
Biomedical Research Center, Fudan University Zhongshan Hospital, Shanghai, China
Search for more papers by this authorCorresponding Author
Tongyu Zhu
Department of Urology, Bucharest, Romania
Shanghai Key Lab of Organ Transplantation, Bucharest, Romania
Correspondence to: Tongyu ZHU, MD, PhD, Prof, Department of Urology, Fudan University Zhongshan Hospital, Shanghai, China.
Tel.: +86 21 64041990 (ext. 5468)
Fax: +86 21 64037269
E-mail: [email protected]
Search for more papers by this authorAbstract
Renal interstitial cells play an important role in the physiology and pathology of the kidneys. As a novel type of interstitial cell, telocytes (TCs) have been described in various tissues and organs, including the heart, lung, skeletal muscle, urinary tract, etc. (www.telocytes.com). However, it is not known if TCs are present in the kidney interstitium. We demonstrated the presence of TCs in human kidney cortex interstitium using primary cell culture, transmission electron microscopy (TEM) and in situ immunohistochemistry (IHC). Renal TCs were positive for CD34, CD117 and vimentin. They were localized in the kidney cortex interstitial compartment, partially covering the tubules and vascular walls. Morphologically, renal TCs resemble TCs described in other organs, with very long telopodes (Tps) composed of thin segments (podomers) and dilated segments (podoms). However, their possible roles (beyond intercellular signalling) as well as their specific phenotype in the kidney remain to be established.
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