Volume 10, Issue 2 pp. 115-118

An increased number of circulating γ/δ TCR + T cells in patients with chronic viral hepatitis

Vassiliki Nikolopoulou,

Corresponding Author

Vassiliki Nikolopoulou

Department of Internal Medicine, University Hospital of Patras, Box 1045, 26110 Patras, Greece

*Corresponding author. Fax: (61) 993 982.Search for more papers by this author

Athanasios Skoutelis,

Athanasios Skoutelis

Department of Internal Medicine, University Hospital of Patras, Box 1045, 26110 Patras, Greece

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Konstantinos Thomopoulos,

Konstantinos Thomopoulos

Department of Internal Medicine, University Hospital of Patras, Box 1045, 26110 Patras, Greece

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Bassam Salsaa,

Bassam Salsaa

Department of Internal Medicine, University Hospital of Patras, Box 1045, 26110 Patras, Greece

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Nicholas Zoumbos,

Nicholas Zoumbos

Department of Internal Medicine, University Hospital of Patras, Box 1045, 26110 Patras, Greece

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Vassiliki Nikolopoulou,

Corresponding Author

Vassiliki Nikolopoulou

Department of Internal Medicine, University Hospital of Patras, Box 1045, 26110 Patras, Greece

*Corresponding author. Fax: (61) 993 982.Search for more papers by this author

Athanasios Skoutelis,

Athanasios Skoutelis

Department of Internal Medicine, University Hospital of Patras, Box 1045, 26110 Patras, Greece

Search for more papers by this author

Konstantinos Thomopoulos,

Konstantinos Thomopoulos

Department of Internal Medicine, University Hospital of Patras, Box 1045, 26110 Patras, Greece

Search for more papers by this author

Bassam Salsaa,

Bassam Salsaa

Department of Internal Medicine, University Hospital of Patras, Box 1045, 26110 Patras, Greece

Search for more papers by this author

Nicholas Zoumbos,

Nicholas Zoumbos

Department of Internal Medicine, University Hospital of Patras, Box 1045, 26110 Patras, Greece

Search for more papers by this author

First published: January 1995

https://doi.org/10.1111/j.1574-695X.1995.tb00019.x

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Abstract

Abstract There is evidence that γ/δ TCR + T cells are specialized in recognizing different antigens, but their immunologic role as a second TCR is still unclear. The aim of this study was to investigate the percentage and absolute numbers of circulating γ/δ TCR + T cells in patients with chronic viral hepatitis (CVH) and to compare with HBsAg⁺, HCV healthy carriers and healthy subjects. Forty nine patients with CVH-24 with chronic active (CAH) and 25 with chronic persistent hepatitis (CPH)-, 21 HBsAg⁺, 20 HCV asymptomatic carriers and 20 healthy subjects were enrolled in the study. Lymphocyte subsets were determined after incubation with monoclonal antibodies to T total (CD5) and T γ/δ cells (γ/δ-1) using immunofluorescence microscopy. An increased number of circulating γ/δ TCR + T cells was found in patients with CVH in comparison with asymptomatic carriers and normal controls: this increase was more profound in patients with CAH, compared to CPH patients. These results indicate a correlation between circulating γ/δ TCR + T cells in CVH patients and activity and chronicity of the disease.

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Volume10, Issue2

January 1995

Pages 115-118

An increased number of circulating γ/δ TCR + T cells in patients with chronic viral hepatitis

Abstract

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An increased number of circulating γ/δ TCR + T cells in patients with chronic viral hepatitis

Abstract

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