Horizontal Gaze Nystagmus: A Review of Vision Science and Application Issues
Steven J. Rubenzer Ph.D.
Private Practice, 11475 Sagecreek, Houston, TX 77089.
Search for more papers by this authorScott B. Stevenson Ph.D.
2152 JDA Building, College of Optometry, University of Houston, Houston, TX 77204-2020.
Search for more papers by this authorSteven J. Rubenzer Ph.D.
Private Practice, 11475 Sagecreek, Houston, TX 77089.
Search for more papers by this authorScott B. Stevenson Ph.D.
2152 JDA Building, College of Optometry, University of Houston, Houston, TX 77204-2020.
Search for more papers by this authorAbstract
Abstract: The Horizontal Gaze Nystagmus (HGN) test is one component of the Standardized Field Sobriety Test battery. This article reviews the literature on smooth pursuit eye movement and gaze nystagmus with a focus on normative responses, the influence of alcohol on these behaviors, and stimulus conditions similar to those used in the HGN sobriety test. Factors such as age, stimulus and background conditions, medical conditions, prescription medications, and psychiatric disorder were found to affect the smooth pursuit phase of HGN. Much less literature is available for gaze nystagmus, but onset of nystagmus may occur in some sober subjects at 45° or less. We conclude that HGN is limited by large variability in the underlying normative behavior, from methods and testing environments that are often poorly controlled, and from a lack of rigorous validation in laboratory settings.
References
- 1 National Highway Traffic Safety Administration. DWI detection and standardized field sobriety testing, participant manual. Washington, DC: U.S. Dept. of Transportation, 2006 HS 178 R8/06.
- 2 National Highway Traffic Safety Administration. DWI detection and standardized field sobriety testing, instructor manual. Washington, DC: U.S. Dept. of Transportation, 2006 HS 178 R8/06.
- 3 American Prosecutors Research Institute. Horizontal Gaze Nystagmus state law summary and chart, 2003, http://www.ndaa.org/pdf/hgn_state_case_law_chart_2003.pdf(accessed January 2009).
- 4 Honts CR, Amato-Henderson SL. Horizontal Gaze Nystagmus test: the state of the science in 1995. N Dakota Law Rev 1995; 71: 671–700.
- 5 State v. McKown, Illinois Supreme Court, Docket No. 102372, Opinion filed September 20, 2007.
- 6 U.S. v. Horn, United States District Court, D. (MD); 2002 185 F.Supp.2d 530.
- 7 State v. Dahood, Concord (NH) District Court; April 2002, #96-JT-707.
- 8 Rubenzer SJ. The standardized field sobriety tests: a history and review of scientific and legal issues. Law Hum Behav 2008; 32(4): 293–313.
- 9 Dodge R, Travis RC, Fox JC. Optic nystagmus: III. characteristics of the slow phase. Arch J Physiol 1930; 8: 307–29.
- 10 Westheimer G. Eye-movement response to a horizontally moving visual stimulus. Arch Opththalmol 1954; 52: 932–41.
- 11 Langenegger T, Meienberg O. Slow conjugate eye movements: normative data for routine diagnosis of ophthalmo-neurological disorders. Neuro-ophthalmology 1988; 8(2): 53–76.
- 12 Ciuffreda KJ, Tannen B. Eye movement basics for the clinician. St. Louis, MO: Mosby, 1995.
- 13 Leigh RJ, Zee DS. The neurology of eye movements, 4th edn. New York, NY: Oxford University Press, 2006.
- 14 Robinson DA. Eye movement control in primates: the oculomotor system contains specialized subsystems for acquiring and tracking visual targets. Science 1968; 161(847): 1219–24.
- 15 Bahill AT, Iandolo MJ, Troost BT. Smooth pursuit eye movement in response to unpredictable target waveforms. Vis Res 1980; 20(11): 923–31.
- 16 Guedry FE, Gilson RD, Schroeder DJ, Collins WE. Some effects of alcohol on various aspects of oculomotor control. Aviat Space Environ Med 1975; 46(8): 1008–13.
- 17 Puckett JD, Steinman RM. Tracking eye movements with and without saccadic correction. Vis Res 1961; 9(6): 695–703.
- 18 Schalen L. Quantification of tracking eye movements in normal subjects. Acta Otolaryngol 1980; 90(6): 404–13.
- 19 Lehtinen I, Nyrke T, Lang AH, Pakkanen A, Keskinen E. Quantitative effects of ethanol infusion on smooth pursuit eye movements in man. Psychopharmacology 1982; 77(1): 74–80.
- 20 Booker JL. The Horizontal Gaze Nystagmus test: fraudulent science in the American courts. Sci Justice 2004; 44(3): 133–9.
- 21 Heinz G, Peterson LG, Johnson RW, Kerk CJ. Exploring relationships in body dimensions. J Stat Educ 2003; 11(2), http://www.amstat.org/publications/jse/v11n2/datasets.heinz.html (accessed January 2009).
- 22 American Prosecutors Research Institute. Horizontal Gaze Nystagmus—the science and the law: a resource guide for judges, prosecutors, and law enforcement. Alexandria, Virginia, 1999, http://www.ndaa.org/pdf/sci_law2.pdf(accessed January 2009).
- 23
Tharp V,
Burns M,
Moskowitz H.
Development and field test of psychophysical tests for DWI arrest. Washington, DC: U.S. Department of Transportation, National Highway Traffic Safety Administration, 1981
Report No.: DOT-HS-805-864, 1981.
10.1037/e730612011-001 Google Scholar
- 24 Citek K. HGN and the role of the optometrist. Admissibility of Horizontal Gaze Nystagmus evidence: targeting hardcore impaired drivers. Alexandria, VA: American Prosecutors Research Institute, 2003, http://www.ndaa.org/pdf/admissibility%20of%20hgn_april_2003.pdf(accessed January 2009).
- 25 Abbott WC. SFSTs: a blessing or a curse? Texas Prosecutor 2005; 35(5): 8–10.
- 26 Talpins SK. Prosecuting drugged driving cases. In: M Burns, editor. Medical-legal aspects of drugs, 2nd edn. Tucson, AZ: Lawyers and Judges Publishing Co, 2007; 155–75.
- 27 Burns M, Citek K. What is the HGN test? Admissibility of Horizontal Gaze Nystagmus evidence: targeting hardcore impaired drivers. Alexandria, VA: American Prosecutors Research Institute; 2003, http://www.ndaa.org/pdf/admissibility%20of%20hgn_april_2003.pdf (accessed January 2009).
- 28 Bertolli ER, Forkiotis J, Pannone DR, Dawkins H. A behavioral optometry/vision science perspective on the Horizontal Gaze Nystagmus exam for DUI enforcement. Forensic Examiner 2007; Spr: 26–33.
- 29 Bobo J. Introduction: the best field sobriety test. Admissibility of Horizontal Gaze Nystagmus evidence: targeting hardcore impaired drivers. Alexandria, VA: American Prosecutors Research Institute, 2003, http://www.ndaa.org/pdf/admissibility%20of%20hgn_april_2003.pdf (accessed January 2009).
- 30 Pangman WA. Horizontal Gaze Nystagmus: voodoo science. DWI J: Law Sci 1987; 2(3): 1–6.
- 31 Coffey M. DWI: modern day Salem witch hunts. The Champion 2004; 28(9): 51–54, 63. http://www.nacdl.org/public.nsf/01c1e7698280d20385256d0b00789923/0ce16f3b9551615c85256f6a00558f3a?OpenDocument (accessed January 2009).
- 32 Rubenzer SJ. The psychometrics and science of the standardized field sobriety tests, Part 1. The Champion 2003; 27(4): 48–54.
- 33 Dell’Osso LF, Daroff RB. Nystagmus and saccadic intrusions and oscillations. In: W Tasman, EA Jaeger, editors. Duane’s clinical ophthalmology, Vol. 2, Rev edn. Philadelphia, PA: Lippencott, Williams & Wilkins, 2005; 1–42.
- 34 State v. Superior Court (Blake), 149 Ariz. 269, 718 P.2d 171 (1986).
- 35 Burns M. An overview of field sobriety test research. Percept Mot Skills 2003; 97: 1187–99.
- 36 Burns M, Anderson EW. A Colorado validation study of the Standardized Field Sobriety Tests (SFST) battery. Washington, DC: U.S. Department of Transportation, National Highway Traffic Safety Administration, 1995.
- 37 Burns M, Dioquino TA. Florida validation study of the standardized field sobriety test (SFST) battery. Washington, DC: U.S. Department of Transportation, National Highway Traffic Safety Administration, 1997. Technical Report.
- 38 Stuster J, Burns M. Validation of the standardized field sobriety test battery at BACs below 0.10 percent. Washington, DC: U.S. Department of Transportation, National Highway Traffic Safety Administration, 1998. Technical Report DOT-HS-808-839.
- 39
Hlastala MP,
Polissar NL,
Oberman S.
Statistical evaluation of standardized field sobriety tests.
J Forensic Sci
2005; 50(3): 1–8.
10.1520/JFS2003386 Google Scholar
- 40 McKnight AJ, Langston EA, McKnight AS, Lange JE. Sobriety tests for low alcohol blood concentrations. Accid Anal Prev 2002; 34(3): 305–11.
- 41 Burns M. The robustness of the horizontal gaze nystagmus test. Washington, DC: U.S. Department of Transportation, National Highway Traffic Safety Administration, 2007. Technical Report.
- 42 Citek K, Ball B, Rutledge DA. Nystagmus testing in intoxicated individuals. Optometry 2003; 74(11): 695–710.
- 43 Compton RP. Pilot test of selected DWI detection procedures for use at sobriety checkpoints. Washington, DC: U.S. Department of Transportation, National Highway Traffic Safety Administration, 1985. Technical Report DOT-HS-806-724.
- 44 McKnight AJ, Lange JE, McKnight AS. Development of a standardized boating sobriety test. Accid Anal Prev 1999; 31(1–2): 147–52.
- 45 Sussman ED, Needalman A, Mengert PH. An experimental evaluation of a field sobriety test battery in the marine environment. Washington, DC: U.S. Department of Transportation, US Coast Guard, 1990. Technical Report prepared under Contract DOT-CG-D-04-90.
- 46 McKnight AJ, Langston EA, Lange JE, McKnight AS. Development of standardized field sobriety tests for lower BAC limits. Washington, DC: U.S. Department of Transportation, National Highway Traffic Safety Administration, 1995. Technical Report prepared under NHTSA Contract DTNH22-92-C-00700.
- 47 Heilbrum K. The role of psychological testing in forensic assessment. Law Hum Behav 1992; 16(3): 257–72.
- 48 Nunnally JC, Bernstein IH. Psychometric theory, 3rd edn. New York, NY: McGraw-Hill, Inc., 1994.
- 49 Robinson DA. The mechanics of human smooth pursuit eye movement. J Physiol 1965; 180(3): 569–91.
- 50 Rashbass P. The relationship between saccadic and smooth pursuit tracking eye movements. J Physiol 1961; 159: 326–38.
- 51 Williams RA, Fender DH. Velocity precision in smooth pursuit eye movements. Vis Res 1979; 19: 343–8.
- 52 Robinson DA. A quantitative analysis of extraocular muscle cooperation and squint. Invest Ophthal Vis Sci 1975; 14: 801–5.
- 53 Hepp K, Henna V. Iso-frequency curves of oculomotor neurons in the rhesus monkey. Vis Res 1985; 25(4): 493–9.
- 54 Sindermann F, Geiselmann B, Fischler M. Electroencephalographic single motor unit activity in extraocular muscles in man during fixation and saccades. Clin Neurophysiol 1978; 45(1): 64–73.
- 55 Baloh RW, Kumley WE, Sills AW, Honrubia V, Konrad HR. Quantitative measurement of smooth pursuit eye movements. Ann Otol Rhino Laryngol 1976; 85(1 Pt 1): 111–9.
- 56 Boman DK, Hotson JR. Smooth pursuit training and disruption: directional differences and nystagmus. Neuro-ophthalmology 1987; 7(4): 185–94.
- 57 Carl JR, Gellman RS. Human smooth pursuit: stimulus-dependent responses. J Neurophysiol 1987; 57(5): 1446–63.
- 58 Collewijn H, Tamminga EP. Human smooth and saccadic eye movements during voluntary pursuit of different target motions on different backgrounds. J Physiol 1984; 351: 217–50.
- 59 Bahill AT, LaRitz T. Why can’t batters keep their eyes on the ball? Amer Scientist 1984; 72(3): 249–53.
- 60 Barmack NH. Dynamic visual acuity as in index of eye movement control. Vis Res 1970; 10(12): 1377–91.
- 61 Buizza A, Schmid R. Velocity characteristics of smooth pursuit eye movements to different patterns of target motion. Exp Brain Res 1986; 63(2): 395–401.
- 62 Buizza A, Schmid R, Gigi MR. The range of linearity of the smooth pursuit control system. In: AG Bale, F Johnson, editors. The theoretical and applied aspects of eye movement research. Amsterdam: Elsevier Science Publ: BV (North–Holland), 1984; 473–80.
- 63 Meyers CH, Lasker AG, Robinson DA. The upper limit of human smooth pursuit velocity. Vis Res 1985; 25(4): 561–3.
- 64 Mizoi Y, Hishida S, Maeba Y. Diagnosis of alcohol intoxication by the optokinetic test. Q J Stud Alcohol 1969; 30(1): 1–14.
- 65 Lencer RM, Clarke AH. Influence of optokinetic and vestibular stimuli on the performance of smooth pursuit eye movements: implications for a clinical test. Acta Oto-Laryngol 1998; 118(2): 161–9.
- 66 Shagass C, Amadeo M, Overton DA. Eye-tracking performance in psychiatric patients. Biol Psychiatry 1974; 9(3): 245–60.
- 67 Siever LJ, Coursey RD, Alterman IS, Buchsbaum MS, Murphy DL. Impaired smooth pursuit movement: vulnerability marker for schizotypal personality disorder in a normal volunteer population. Am J Psychiatry 1984; 141(12): 1560–6.
- 68 Holzman PS, Proctor LR, Levy DL, Yasillo NJ, Meltzer RY, Hurt SW. Eye-tracking dysfunctions in schizophrenic patients and their relatives. Arch Gen Psychiatry 1974; 31(2): 143–51.
- 69 Kobatake K, Yoshii F, Shinohara Y, Nomura K, Takagi S. Impairment of smooth pursuit eye movements in chronic alcoholics. Eur Neurol 1983; 22(6): 392–6.
- 70 Flom MC, Brown B, Adams AJ, Jones RT. Alcohol and marijuana effects on ocular tracking. Am J Optom Physiol Opt 1976; 53(12): 764–73.
- 71 Moser A, Heide W, Kömpf D. The effect of oral ethanol consumption on eye movements in healthy volunteers. J Neurol 1998; 245(8): 542–50.
- 72 Ross RG, Olincy A, Harris JG, Sullivan B, Radant A. Smooth pursuit eye movements in schizophrenia and attentional dysfunction: adults with schizophrenia, ADHD, and a normal comparison group. Biol Psychiatry 2000; 48(3): 197–203.
- 73 Corvera J, Torres-Courtney G, Lopez-Rios G. The neurological significance of alterations of pursuit eye movements and the pendular eye tracking test. Ann Otol Rhinol Laryngol 1973; 82: 855–67.
- 74 Von Noorden GK, Mackensen G. Pursuit movements in normal and amblyopic eyes. An electro-ophthalmographical study: I. Physiology of pursuit movements. Amer J Ophthalmol 1962; 53: 325–36.
- 75 Bono F, Oliveri RL, Zappia M, Aguglia U, Puccio G, Quattrone A. Computerized analysis of eye movements as a function of age. Arch Gerontology Geriatrics, 1995; 22(3): 261–9.
- 76 Chan T, Codd M, Kenny P, Eustace P. The effect of aging on catch-up saccades during horizontal smooth pursuit eye movement. Neuroophthalmol 1990; 10(6): 327–30.
- 77 Kuchenmeister CA, Linton PH, Mueller TV, White HB. Eye tracking in relation to age, sex, and illness. Arch Gen Psychiatry 1977; 34(5): 578–9.
- 78 Morrow MJ, Sharpe JA. Smooth pursuit initiation in young and elderly subjects. Vis Res 1993; 33(2): 203–10.
- 79 Spooner JW, Sakala SM, Baloh RW. Effect of aging on eye tracking. Arch Neurol 1980; 37(9): 575–6.
- 80 Sharpe JA, Sylvester TO. Effect of aging on horizontal smooth pursuit. Invest Opthalmol Vis Sci 1978; 17: 465–8.
- 81 Barnes GR, Asselman PT. Pursuit of intermittently illuminated moving targets in the human. J Physiol 1992; 445: 617–37.
- 82 Bennett SJ, Barnes GR. Predictive smooth ocular pursuit during the transient disappearance of a visual target. J Neurophysiol 2004; 92: 578–90.
- 83 Rambold H, Baz IE, Helmchen C. Blink effects on ongoing smooth pursuit movements. Exp Brain Res 2005; 161(1): 11–26.
- 84 Krauzlis RJ. Recasting the smooth pursuit eye movement system. J Neurophysiol 2004; 91: 592–603.
- 85 Hutton SB, Tegally D. The effects of dividing attention on smooth pursuit eye tracking. Exp Brain Res 2005; 163(3): 306–13.
- 86 Kathmann N, Hochrein A, Uwer R. Effects of dual task demands on the accuracy of smooth pursuit eye movements. Psychophysiology 1999; 36: 158–63.
- 87 Kaufman SR, Abel LA. The effects of distraction on smooth pursuit in normal subjects. Acta Otolaryngol 1986; 102: 57–64.
- 88 Van Gelder P, Lebedev S, Liu PM, Tsui WH. Anticipatory saccades in smooth pursuit: task effects and pursuit vector after saccades. Vis Res 1995; 35: 667–78.
- 89 Acker W, Toone B. Attention, eye tracking and schizophrenia. Br J Soc Clin Psychol 1978; 17: 173–81.
- 90 Brezinova V, Kendell RE. Smooth pursuit eye movements of schizophrenics and normal people under stress. Br J Psychiatry 1977; 130: 59–63.
- 91 Lipton RB, Frost LA, Holzman PS. Smooth pursuit eye movements, schizophrenia, and distraction. Percept Mot Skills 1980; 50: 159–67.
- 92 Barnes GR, Crombie JW. The interaction of conflicting retinal motion stimuli in oculomotor control. Exp Brain Res 1985; 59: 548–58.
- 93 Van Gelder P, Anderson S, Herman E, Lebedev S, Tsui WH. Saccades in pursuit eye tracking reflect motor attention processes. Compr Psychiatry 1990; 31(3): 253–60.
- 94 Van den Berg AV, Collewijn H. Human smooth pursuit: effects of stimulus extent and of spatial and temporal constraints of the pursuit trajectory. Vis Res 1986; 26: 1209–22.
- 95 Yee RD, Daniels SA, Jones OW, Baloh RW, Honrubia V. Effects of an optokinetic background on pursuit eye movements. Invest Ophthalmol Vis Sci 1983; 24: 1115–22.
- 96 Howard IP, Marton C. Visual pursuit over textured backgrounds in different depth planes. Exp Brain Res 1992; 90(3): 625–9.
- 97 Worfolk R, Barnes GR. Interaction of active and passive slow eye movement systems. Exp Brain Res 1992; 90(3): 589–98.
- 98 Masson G, Proteau L, Mestre DN. Effects of stationary and moving textured backgrounds on the visio-oculo-manual tracking in humans. Vis Res 1995; 35(6): 837–52.
- 99 Schor CM. Neural control of eye movements. In: PL Kaufman, A Alm, editors. Adler’s physiology of the eye. St. Louis, MO: Mosby, 1974; 830–58.
- 100 Roy-Byrne P, Radant A, Wingerson D, Cowley DS. Human oculomotor function: reliability and diurnal variation. Biol Psychiatry 1995; 38(2): 92–7.
- 101 Citek K, Arlien A, Jons C, Krezelok C, Neron J, Plummer T, et al. Sleep deprivation does not cause eye movements that mimic alcohol intoxication. Optom Vis Sci 2005; 82:E-abstract 055223 (poster presentation).
- 102 De Gennaro L, Ferrara M, Urbani L, Bertini M. Oculomotor impairment after 1 night of total sleep deprivation: a dissociation between measures of speed and accuracy. Clinical Neurophysiology 2000; 111: 1771–8.
- 103 Porcu S, Ferrara M, Urbani L, Bellatreccia A, Casagrande M. Smooth pursuit and saccadic eye movements as possible indicators of nighttime sleepiness. Physiol Behav 1998; 65: 437–43.
- 104 Campion D, Thibault F, Denise P, Courtin P, Pottier M, Levillain D. SPEM in drug-naïve schizophrenia: evidence for a trait marker. Biol Psychiatry 1992; 32(10): 891–902.
- 105 Gooding DC, Iacono WG, Beiser M. Temporal stability of smooth-pursuit eye tracking in first-episode psychosis. Psychophysiol 1994; 31: 62–7.
- 106 Ciuffreda KJ, Goldrich SG, Neary C. Control of nystagmus using eye movement auditory feedback. In: G Lennerstrand, DS Lee, EL Keller, editors. Functional basis of ocular motility disorders. Elmsford, NY: Oxford, Pergamon, 1982; 147–50.
- 107 Boman DK, Hotson JR. Smooth pursuit training and disruption: directional differences and nystagmus. Neuroophthal 1987; 7(4): 185–94.
- 108 Hartje W, Steinhaüser D, Kerschensteiner M. Diagnostic value of saccadic pursuit eye movement in screening for organic cerebral dysfunction. J Neurol 1978; 217(4): 253–60.
- 109 Reulen JPH, Sanders EACM, Hogenhuis LAH. Eye movement disorders in multiple sclerosis and optic neuritis. Brain 1983; 106(1): 121–40.
- 110 Citek K. Visual function, drugs, and field sobriety tests. In: M Burns, editor. Medico-legal aspects of drugs, 2nd edn. Tucson, AZ: Lawyers & Judges Publishing Company, Inc., 2007; 203–19.
- 111 Schultz v. State, 106 Md. App. 145, 664 A.2d 60 (1995).
- 112
Diefendorf AR,
Dodge R.
An experimental study of the ocular reaction of the insane from photographic records.
Brain
1908; 31(3): 451–9.
10.1093/brain/31.3.451 Google Scholar
- 113 Levy DL, Holzman PS, Matthysse S, Mendell NR. Eye tracking and schizophrenia: a selective review. Schizophr Bull 1994; 20(1): 47–62.
- 114 Ettinger U, Kumari V, Crawford TJ, Corr PJ, Dasa M, Zachariaha E, et al. Smooth pursuit and antisaccade eye movements in siblings discordant for schizophrenia. J Psychiatr Res 2004; 38(2): 177–84.
- 115 Iacono WG, Peloquin WJ, Lumry AE, Valentine RH, Tuason VB. Eye tracking in patients with unipolar and bipolar affective disorders in remission. J Abnorm Psychol 1982; 91(1): 35–44.
- 116 Ettinger U, Kumari V, Crawford TJ, Flak V, Sharma T, Davis RE, et al. Saccadic eye movements, schizotypy, and the role of neuroticism. Biol Psychology 2005; 68: 61–78.
- 117 Sherr JD, Myers C, Avila MT, Elliott A, Blaxton TA, Thaker GK. The effects of nicotine on specific eye tracking measures in schizophrenia. Biol Psychiatry 2002; 52(7): 721–8.
- 118 Dépatie L, O’Driscoll GA, Holahan A-LV, Atkinson V, Thavundayil JX, Ng Ying Kin N, et al. Nicotine and behavioral markers of risk for schizophrenia: a double-blind, placebo-controlled, cross-over study. Neuropsychopharmacology 2002; 27(6): 1056–69.
- 119 Bylsma FW, Pivik RT. The effects of background illumination and stimulant medication on smooth pursuit eye movements of hyperactive children. J Abn Child Psych 1989; 17(1): 73–90.
- 120 Vickers JN, Rodrigues ST, Brown LN. Gaze pursuit and arm control of adolescent males diagnosed with attention deficit hyperactivity disorder (ADHD) and normal controls: evidence of a dissociation in processing visual information of short and long duration. J Sports Sci 2002; 20(3): 201–16.
- 121 Sibony PA, Evinger C, Manning KA. Tobacco-induced primary position upbeat nystagmus. Ann Neurol 1987; 21(1): 53–8.
- 122 Pereira CB, Strupp MCA, Holzleiter T, Brandt T. Smoking and balance: correlation of nicotine-induced nystagmus and postural body sway. Neuroreport 2001; 12(6): 1223–6.
- 123 Sibony PA, Evinger C, Manning KA. The effects of tobacco smoking on smooth pursuit eye movements. Ann Neurol 1988; 23(3): 238–41.
- 124 Thaker GK, Ellsberry R, Moran M, Lahti A, Tamminga C. Tobacco smoking increases square-wave jerks during pursuit eye movements. Biol Psychiatry 1991; 29(1): 82–8.
- 125 Avila MT, Sherr JD, Hong E, Myers CS, Thaker GK. Effects of nicotine on leading saccades during smooth pursuit eye movements in smokers and nonsmokers with schizophrenia. Neuropsychopharmacology 2003; 28: 2184–91.
- 126 Olincy A, Johnson LL, Ross RG. Differential effects of cigarette smoking on performance of a smooth pursuit and a saccadic eye movement task in schizophrenia. Psychiatry Res 2003; 117(3): 223–36.
- 127 Domino EF, Ni LS, Zhang H. Effects of tobacco smoking on human ocular smooth pursuit. Clin Pharmacol Ther 1997; 61(3): 349–59.
- 128 Ettinger U, Kumari V, Crawford TJ, Davis RE, Sharma T, Corr PJ. Reliability of smooth pursuit, fixation, and saccadic eye movements. Psychophysiology 2003; 40: 620–8.
- 129 Iacano WG, Lykken DT. Two-year retest stability of eye-tracking performance and a comparison of electro-oculographic tracking performance and infrared recording techniques: evidence of electroencephalogram in the electro-oculogram. Psychophysiology 1981; 18(1): 49–55.
- 130 Mundt JC, Perrine MW, Searles JS. Individual difference in alcohol responsivity: physiological, psychomotor, and subjective response domains. J Stud Alcohol 1997; 58(2): 130–40.
- 131 Baloh RW, Sharma S, Moskowitz H, Griffith R. Effect of alcohol and marijuana on eye movements. Aviat Space Environ Med 1979; 50(1): 18–23.
- 132 Bittencourt P, Wade P, Richens A, Smith T, Lloyd D, Toseland P. Blood alcohol and eye movements. Lancet 1980; 2(8201): 981.
- 133 Levy DL, Lipton RB, Holzman PS. Smooth pursuit eye movements: effects of alcohol and chloral hydrate. J Psychiatr Res 1981; 16(1): 1–11.
- 134 Wilkinson IMS, Kime R, Purnell M. Alcohol and human eye movement. Brain 1974; 97: 785–92.
- 135 Takahashi M, Akiyama I, Tsujita N, Yoshida A. The effect of alcohol on the vestibulo-ocular reflex and gaze regulation. Eur Arch Otorhinolaryngol 1989; 246(4): 195–9.
- 136 Blekher T, Miller K, Yee RD, Christian JC, Abel LA. Smooth pursuit in twins before and after alcohol ingestion. Invest Ophthal Vis Sci 1997; 38(9): 1768–73.
- 137 Robinson DA, Zee DS, Hain TC, Holmes A, Rosenberg LF. Alexander’s law: its behavior and origin in the human vestibule-ocular reflex. Ann Neurol 1984; 16(6): 714–22.
- 138 Munez DP, Armstrong IT, Hampton KA, Moore KD. Alerted control of visual fixation and saccadic eye movement in attention-deficit hyperactivity disorder. J Neurophysiology 2003; 90: 503–14.
- 139 Amador XF, Malaspina D, Sackeim HA, Coleman EA, Kaufmann CA, Hasan A, et al. Visual fixation and smooth pursuit eye movement abnormalities in patients with schizophrenia and their relatives. J Neuropsychiatry Clin Neurosci 1995; 7: 197–206.
- 140 Tharp VK, Mosokowitz H, Burns M. Circadian effects on alcohol gaze nystagmus [abstract]. Psychophysiology 1981; 18: 193.
- 141 Booker JL. End-position nystagmus as an indicator of ethanol intoxication. Sci Justice 2001; 41(2): 113–6.
- 142 Duke-Elder WS. Text-book of ophthalmology. St. Louis, MO: CV Mosby Co, 1933.
- 143 Coates AC. Electronystagmography. In: LJ Bradford, editor. Physiological measures of the audio-vestibular system. New York, NY: Academic Press, 1975; 37–85.
- 144 Blomberg L–H. The significance of so-called “end-position nystagmus” and its relation to nystagmus produced by evipan. Acta Psychiatr Neurol Scand 1958; 33(2): 138–50.
- 145 Godde-Jolly D, Ruelalan YU–M, Hudelo J. Nystagmus du regard extreme. Rev Otoneuroophtal 1970; 42: 44–56.
- 146 Abadi RV, Scallan CJ. Ocular oscillation on eccentric gaze. Vis Res 2001; 41(22): 2895–907.
- 147 Abel LA, Parker L, Daroff RB, Dell’Osso LF. End-point nystagmus. Invest Ophthalmol Vis Sci 1978; 17: 539–44.
- 148 Schmidt D, Kommerell G. Endstellungs-nystagmus als ermungstrekatioin bei extreme Seitwärtsblick. Albrecht v. Graefes Arch Klin Exp Ophthalmol 1976; 198: 17–24.
- 149 Shechtman D, Shallo-Hoffmann J, Rumsey J, Riordan-Eva P, Hardigan P. Maximum angle of ocular duction during visual fixation as a function of age. Strabismus 2005; 13(1): 21–6.
- 150 Yamashiro M. Objective measurement of the limit of uniocular movement. Jpn J Opthalmol 1957; 1: 130–6.
- 151 Büttner U, Grundei T. Gaze evoked nystagmus and smooth pursuit deficits: their relationship studied in 52 patients. J Neurol 1995; 242(6): 384–9.
- 152 Aschan G. Different types of alcohol nystagmus. Acta Otolaryngol (Stockh) 1958; 140: 169–78.
- 153 Goding GS, Dobie R. Gaze nystagmus blood alcohol. Laryngoscope 1986; 96(7): 713–7.
- 154 Lehti HMJ. The effect of blood alcohol concentration on the onset of gaze nystagmus. Blutalkohol 1976; 13: 411–4.
- 155 State v. Witte, 251 Kan. 313, 836 P.2d 1110 (1992).
- 156
Barko JJ.
Measurement and reliability: statistical thinking considerations.
Schiz Bull
1991; 17(3): 483–9.
10.1093/schbul/17.3.483 Google Scholar
- 157 Shrout PE, Fleiss JL. Intraclass correlations: uses in assessing rater reliability. Psych Bull 1979; 8(2): 420–8.
- 158 Schuck P. Assessing reproducibility for interval data in health-related quality of life questionnaires: which coefficient should be used? Qual Life Res 2004; 13: 571–86.
- 159 Shallo-Hoffman J, Schwarze H, Mühlendyck H. A reexamination of end-point and rebound nystagmus in normals. Invest Ophthalmol Vis Sci 1990; 31(2): 388–92.
- 160 Wilson JR, Plomin R. Individual differences in sensitivity to alcohol. Soc Biol 1985; 32(3–4): 162–84.
- 161 Wilson JR, Nagoshi CT. One-month repeatability of alcohol metabolism, sensitivity and acute tolerance. J Stud Alcohol 1987; 48(5): 437–42.
- 162 Senter RJ. Analysis of data: introductory statistics for the behavioral sciences. Glenview, IL: Scott, Foresman & Co., 1969.
- 163 Kennedy RS, Turnage JJ, Rugotzke GG, Dunlap WP. Indexing cognitive tests to alcohol dosage and comparison to standardized field sobriety tests. J Stud Alcohol 1994; 55(5): 615–28.
- 164 Cesarelli M, Bifulco P, Loffredo L, Bracale M. Relationship between visual acuity and eye position variability during foveation in congenital nystagmus. Doc Ophthalmol 2000; 101(1): 59–72.
- 165 Chung ST, Bedell HE. Congenital nystagmus image motion: influence on visual acuity at different luminances. Optom Vis Sci 1997; 74(5): 266–72.
- 166 Chung ST, Bedell HE. Velocity criteria for “foveation periods” determined from image motions simulating congenital nystagmus. Optom Vis Sci 1996; 73(2): 92–103.
- 167 Dell’Osso LF, Jacobs JB. An expanded nystagmus acuity function: intra- and intersubject prediction of best-corrected visual acuity. Doc Ophthalmol 2002; 104(3): 249–76.
- 168 Ukwade MT, Bedell HE. Stereothresholds in persons with congenital nystagmus and in normal observers during comparable retinal image motion. Vis Res 1999; 39(17): 2963–73.
- 169 Stapleton JM, Guthrie S, Linnoila M. Effects of alcohol and other psychotropic drugs on eye movements: relevance to traffic safety. J Stud Alcohol 1986; 47(5): 426–32.
- 170 Buikhuisen W, Jongman RW. Traffic perception under the influence of alcohol. Q J Stud Alc 1972; 33: 800–6.
- 171 Halperin E, Yolton RL. Is the driver drunk? Oculomotor sobriety testing. J Am Optom Assoc 1986; 57(9): 654–7.
- 172 Meehl PE, Rosen A. Antecedent probability and the efficiency of psychometric signs, patterns, and cutting scores. Psychol Bull 1955; 52(3): 194–216.