Texas Population Substructure and Its Impact on Estimating the Rarity of Y STR Haplotypes from DNA Evidence*

Bruce Budowle Ph.D.

Institute of Investigative Genetics, University of North Texas Health Science Center at Ft. Worth, Ft. Worth, TX 76107.

Department of Forensic and Investigative Genetics, University of North Texas Health Science Center at Ft. Worth, Ft. Worth, TX 76107.

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Jianye Ge M.S.,

Jianye Ge M.S.

Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH 45221.

Department of Environmental Health, Center for Genome Information, University of Cincinnati College of Medicine, Cincinnati, OH 45267.

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Xavier G. Aranda M.S.,

Xavier G. Aranda M.S.

Department of Forensic and Investigative Genetics, University of North Texas Health Science Center at Ft. Worth, Ft. Worth, TX 76107.

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John V. Planz Ph.D.,

John V. Planz Ph.D.

Department of Forensic and Investigative Genetics, University of North Texas Health Science Center at Ft. Worth, Ft. Worth, TX 76107.

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Arthur J. Eisenberg Ph.D.,

Arthur J. Eisenberg Ph.D.

Institute of Investigative Genetics, University of North Texas Health Science Center at Ft. Worth, Ft. Worth, TX 76107.

Department of Forensic and Investigative Genetics, University of North Texas Health Science Center at Ft. Worth, Ft. Worth, TX 76107.

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Ranajit Chakraborty Ph.D.,

Ranajit Chakraborty Ph.D.

Department of Environmental Health, Center for Genome Information, University of Cincinnati College of Medicine, Cincinnati, OH 45267.

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Bruce Budowle Ph.D.,

Bruce Budowle Ph.D.

Institute of Investigative Genetics, University of North Texas Health Science Center at Ft. Worth, Ft. Worth, TX 76107.

Department of Forensic and Investigative Genetics, University of North Texas Health Science Center at Ft. Worth, Ft. Worth, TX 76107.

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Jianye Ge M.S.,

Jianye Ge M.S.

Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH 45221.

Department of Environmental Health, Center for Genome Information, University of Cincinnati College of Medicine, Cincinnati, OH 45267.

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Xavier G. Aranda M.S.,

Xavier G. Aranda M.S.

Department of Forensic and Investigative Genetics, University of North Texas Health Science Center at Ft. Worth, Ft. Worth, TX 76107.

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John V. Planz Ph.D.,

John V. Planz Ph.D.

Department of Forensic and Investigative Genetics, University of North Texas Health Science Center at Ft. Worth, Ft. Worth, TX 76107.

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Arthur J. Eisenberg Ph.D.,

Arthur J. Eisenberg Ph.D.

Institute of Investigative Genetics, University of North Texas Health Science Center at Ft. Worth, Ft. Worth, TX 76107.

Department of Forensic and Investigative Genetics, University of North Texas Health Science Center at Ft. Worth, Ft. Worth, TX 76107.

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Ranajit Chakraborty Ph.D.,

Ranajit Chakraborty Ph.D.

Department of Environmental Health, Center for Genome Information, University of Cincinnati College of Medicine, Cincinnati, OH 45267.

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First published: 01 September 2009

https://doi.org/10.1111/j.1556-4029.2009.01105.x

Citations: 32

Additional information and reprint requests:
Bruce Budowle
Institute of Investigative Genetics
Department of Forensic and Investigative Genetics
University of North Texas Health Science Center at Ft. Worth
3500 Camp Bowie Blvd
Ft. Worth, TX 76107
E-mail: [email protected]

08–14 is publication number of the Laboratory Division of the Federal Bureau of Investigation. Names of commercial manufacturers are provided for identification only, and inclusion does not imply endorsement by the Federal Bureau of Investigation.

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Abstract

Abstract: Three sampled populations of unrelated males—African American, Caucasian, and Hispanic, all from Texas—were typed for 16 Y short tandem repeat (STR) markers using the AmpFlSTR^® Yfiler^TM kit. These samples also were typed previously for the 13 core CODIS autosomal STR loci. Most of the 16 marker haplotypes (2478 out of 2551 distinct haplotypes) were observed only once in the data sets. Haplotype diversities were 99.88%, 99.89%, and 99.87% for the African American, Caucasian, and Hispanic sample populations, respectively. F_ST values were very small when a haplotype comprised 10–16 markers. This suggests that inclusion of substructure correction is not required. However, haplotypes consisting of fewer loci may require the inclusion of F_ST corrections. The testing of independence of autosomal and Y STRs supports the proposition that the frequencies of autosomal and Y STR profiles can be combined using the product rule.

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Volume54, Issue5

September 2009

Pages 1016-1021

Texas Population Substructure and Its Impact on Estimating the Rarity of Y STR Haplotypes from DNA Evidence*

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Texas Population Substructure and Its Impact on Estimating the Rarity of Y STR Haplotypes from DNA Evidence*

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