High-resolution Diffusion Tensor Imaging for the Detection of Diffusion Abnormalities in the Trigeminal Nerves of Patients with Trigeminal Neuralgia Caused by Neurovascular Compression

Shunrou Fujiwara PhD

From the Advanced Medical Research Center, Iwate Medical University, Morioka, Japan (SF, MS, KK, AO, MY); Department of Neurosurgery, Iwate Medical University, Morioka, Japan (TW, RH, DI, YN, KO).

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Makoto Sasaki MD,

Makoto Sasaki MD

From the Advanced Medical Research Center, Iwate Medical University, Morioka, Japan (SF, MS, KK, AO, MY); Department of Neurosurgery, Iwate Medical University, Morioka, Japan (TW, RH, DI, YN, KO).

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Tsukasa Wada MD,

Tsukasa Wada MD

From the Advanced Medical Research Center, Iwate Medical University, Morioka, Japan (SF, MS, KK, AO, MY); Department of Neurosurgery, Iwate Medical University, Morioka, Japan (TW, RH, DI, YN, KO).

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Kohsuke Kudo MD,

Kohsuke Kudo MD

From the Advanced Medical Research Center, Iwate Medical University, Morioka, Japan (SF, MS, KK, AO, MY); Department of Neurosurgery, Iwate Medical University, Morioka, Japan (TW, RH, DI, YN, KO).

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Ryonoshin Hirooka MD,

Ryonoshin Hirooka MD

From the Advanced Medical Research Center, Iwate Medical University, Morioka, Japan (SF, MS, KK, AO, MY); Department of Neurosurgery, Iwate Medical University, Morioka, Japan (TW, RH, DI, YN, KO).

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Daiya Ishigaki MD,

Daiya Ishigaki MD

From the Advanced Medical Research Center, Iwate Medical University, Morioka, Japan (SF, MS, KK, AO, MY); Department of Neurosurgery, Iwate Medical University, Morioka, Japan (TW, RH, DI, YN, KO).

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Yasumasa Nishikawa MD,

Yasumasa Nishikawa MD

From the Advanced Medical Research Center, Iwate Medical University, Morioka, Japan (SF, MS, KK, AO, MY); Department of Neurosurgery, Iwate Medical University, Morioka, Japan (TW, RH, DI, YN, KO).

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Ayumi Ono MD,

Ayumi Ono MD

From the Advanced Medical Research Center, Iwate Medical University, Morioka, Japan (SF, MS, KK, AO, MY); Department of Neurosurgery, Iwate Medical University, Morioka, Japan (TW, RH, DI, YN, KO).

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Mao Yamaguchi MD,

Mao Yamaguchi MD

From the Advanced Medical Research Center, Iwate Medical University, Morioka, Japan (SF, MS, KK, AO, MY); Department of Neurosurgery, Iwate Medical University, Morioka, Japan (TW, RH, DI, YN, KO).

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Kuniaki Ogasawara MD,

Kuniaki Ogasawara MD

From the Advanced Medical Research Center, Iwate Medical University, Morioka, Japan (SF, MS, KK, AO, MY); Department of Neurosurgery, Iwate Medical University, Morioka, Japan (TW, RH, DI, YN, KO).

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Shunrou Fujiwara PhD,

Shunrou Fujiwara PhD

From the Advanced Medical Research Center, Iwate Medical University, Morioka, Japan (SF, MS, KK, AO, MY); Department of Neurosurgery, Iwate Medical University, Morioka, Japan (TW, RH, DI, YN, KO).

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Makoto Sasaki MD,

Makoto Sasaki MD

From the Advanced Medical Research Center, Iwate Medical University, Morioka, Japan (SF, MS, KK, AO, MY); Department of Neurosurgery, Iwate Medical University, Morioka, Japan (TW, RH, DI, YN, KO).

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Tsukasa Wada MD,

Tsukasa Wada MD

From the Advanced Medical Research Center, Iwate Medical University, Morioka, Japan (SF, MS, KK, AO, MY); Department of Neurosurgery, Iwate Medical University, Morioka, Japan (TW, RH, DI, YN, KO).

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Kohsuke Kudo MD,

Kohsuke Kudo MD

From the Advanced Medical Research Center, Iwate Medical University, Morioka, Japan (SF, MS, KK, AO, MY); Department of Neurosurgery, Iwate Medical University, Morioka, Japan (TW, RH, DI, YN, KO).

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Ryonoshin Hirooka MD,

Ryonoshin Hirooka MD

From the Advanced Medical Research Center, Iwate Medical University, Morioka, Japan (SF, MS, KK, AO, MY); Department of Neurosurgery, Iwate Medical University, Morioka, Japan (TW, RH, DI, YN, KO).

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Daiya Ishigaki MD,

Daiya Ishigaki MD

From the Advanced Medical Research Center, Iwate Medical University, Morioka, Japan (SF, MS, KK, AO, MY); Department of Neurosurgery, Iwate Medical University, Morioka, Japan (TW, RH, DI, YN, KO).

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Yasumasa Nishikawa MD,

Yasumasa Nishikawa MD

From the Advanced Medical Research Center, Iwate Medical University, Morioka, Japan (SF, MS, KK, AO, MY); Department of Neurosurgery, Iwate Medical University, Morioka, Japan (TW, RH, DI, YN, KO).

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Ayumi Ono MD,

Ayumi Ono MD

From the Advanced Medical Research Center, Iwate Medical University, Morioka, Japan (SF, MS, KK, AO, MY); Department of Neurosurgery, Iwate Medical University, Morioka, Japan (TW, RH, DI, YN, KO).

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Mao Yamaguchi MD,

Mao Yamaguchi MD

From the Advanced Medical Research Center, Iwate Medical University, Morioka, Japan (SF, MS, KK, AO, MY); Department of Neurosurgery, Iwate Medical University, Morioka, Japan (TW, RH, DI, YN, KO).

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Kuniaki Ogasawara MD,

Kuniaki Ogasawara MD

From the Advanced Medical Research Center, Iwate Medical University, Morioka, Japan (SF, MS, KK, AO, MY); Department of Neurosurgery, Iwate Medical University, Morioka, Japan (TW, RH, DI, YN, KO).

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First published: 24 March 2011

https://doi.org/10.1111/j.1552-6569.2010.00508.x

Citations: 64

Correspondence: Address correspondence to Makoto Sasaki, MD, Advanced Medical Research Center, Iwate Medical University, 19-1 Uchimaru, Morioka 020-8505, Japan. E-mail: [email protected].

Funding source: Grant-in-Aid for Strategic Medical Science Research Center and Grant-in-Aid for Science Research (20591693) from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

Conflict of Interest: None.

J Neuroimaging 2011;21:e102-e108.

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Abstract

ABSTRACT

PURPOSE

To detect diffusion abnormalities in the trigeminal nerves of patients with trigeminal neuralgia (TN) caused by neurovascular compression (NVC) by using a high-resolution diffusion tensor imaging (HR-DTI) technique.

METHODS

Thirteen patients with TN and 14 healthy controls underwent HR-DTI scanning. After extracting the trigeminal nerve using a tractography technique, we measured the fractional anisotropy (FA) and apparent diffusion coefficient (ADC), and compared the contralateral ratios (CR) of these parameters between the patients and controls, and correlated these ratios with the cross-sectional areas of the nerves.

RESULTS

The CRs of the FA values for the trigeminal nerves of the patients (1.00 ± 0.15) had significantly higher variance than those of healthy controls (1.00 ± 0.05) (P < .05) and showed a positive correlation with the cross-sectional area of the nerves (r= 0.81). In contrast, the CRs of the ADC values were not significantly different between the two groups (1.02 ± 0.10 and 1.01 ± 0.08, respectively) and had no significant correlation with cross-sectional area.

CONCLUSION

HR-DTI can detect an alteration in the relative FA values of affected trigeminal nerves and a correlation with atrophic changes in patients with NVC-induced TN.

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Volume21, Issue2

April 2011

Pages e102-e108

High-resolution Diffusion Tensor Imaging for the Detection of Diffusion Abnormalities in the Trigeminal Nerves of Patients with Trigeminal Neuralgia Caused by Neurovascular Compression

Abstract

ABSTRACT

PURPOSE

METHODS

RESULTS

CONCLUSION

References

Citing Literature

References

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High-resolution Diffusion Tensor Imaging for the Detection of Diffusion Abnormalities in the Trigeminal Nerves of Patients with Trigeminal Neuralgia Caused by Neurovascular Compression

Abstract

ABSTRACT

PURPOSE

METHODS

RESULTS

CONCLUSION

References

Citing Literature

References

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