Detection of Carotid Artery Plaque Ulceration Using 3-Dimensional Ultrasound

John Heliopoulos MD

From the Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece (JH, KV, CP); Stroke and Neurovascular Center, Department of Neurology, Henry Ford Health System, Detroit, Michigan (PM).

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Konstantinos Vadikolias MD,

Konstantinos Vadikolias MD

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Charitomeni Piperidou MD,

Charitomeni Piperidou MD

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Panayiotis Mitsias MD,

Panayiotis Mitsias MD

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John Heliopoulos MD,

John Heliopoulos MD

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Konstantinos Vadikolias MD,

Konstantinos Vadikolias MD

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Charitomeni Piperidou MD,

Charitomeni Piperidou MD

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Panayiotis Mitsias MD,

Panayiotis Mitsias MD

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First published: 24 March 2011

https://doi.org/10.1111/j.1552-6569.2009.00450.x

Citations: 33

Correspondence: Address correspondence to John Heliopoulos, Democritus University of Thrace—Department of Neurology, University General Hospital of Alexandroupolis Dragana Region, Alexandroupolis 68100, Greece. E-mail: [email protected].

J Neuroimaging 2011;21:126-131.

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Abstract

ABSTRACT

BACKGROUND

Three-dimensional (3D) ultrasound imaging is a new technique that maximizes the information and image quality of traditional 2-dimensional (2D) B-mode scanning. The aim of this study was to evaluate the ability of the 3D ultrasound technique to characterize ulcerated atherosclerotic carotid plaque.

METHODS

Using conventional 2D ultrasound, we examined 284 carotid arteries from 142 consecutive patients (101 men and 41 women; average age, 64 years). Eighty-two carotid arteries were symptomatic with atherosclerotic plaque causing 50-99% stenosis. In 62 arteries, the atherosclerotic plaques were visualized completely and were further processed to construct 3D images. Two independent observers rated plaque morphology according to a standardized protocol.

RESULTS

The 3D ultrasound showed carotid plaque ulceration more frequently than the 2D method (16.1% and 14.5% of plaques, for observers 1 and 2, respectively, versus 6.5% and 9.7% of plaques, for observers 1 and 2, respectively, P= .125 and P= .063, for observers 1 and 2, respectively). The interobserver reproducibility was very good for both methods (κ= .973, SE = .027, P < .001 for 3D, and κ= .885, SE = .055, P < .001 for 2D), although the 3D method was slightly superior to 2D.

CONCLUSIONS

3D ultrasound reliably characterized the surface morphology of atherosclerotic carotid plaques. A trend of superiority of 3D ultrasound over 2D was found in detecting ulcers of carotid artery plaque.

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Volume21, Issue2

April 2011

Pages 126-131

Detection of Carotid Artery Plaque Ulceration Using 3-Dimensional Ultrasound

Abstract

ABSTRACT

BACKGROUND

METHODS

RESULTS

CONCLUSIONS

References

Citing Literature

References

Information

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Detection of Carotid Artery Plaque Ulceration Using 3-Dimensional Ultrasound

Abstract

ABSTRACT

BACKGROUND

METHODS

RESULTS

CONCLUSIONS

References

Citing Literature

References

Related

Information