Determination of Hemispheric Dominance with Mental Rotation Using Functional Transcranial Doppler Sonography and fMRI
Katja Hattemer MD
From the Department of Neurology, Interdisciplinary Epilepsy Center, Philipps-University Marburg, Marburg, Germany (KH, AP, AH, KMK, AH, WHO, HMH, FR, SK); and Department of Radiology, Philipps-University Marburg, Marburg, Germany (JTH, BK).
Search for more papers by this authorAnnika Plate MD
From the Department of Neurology, Interdisciplinary Epilepsy Center, Philipps-University Marburg, Marburg, Germany (KH, AP, AH, KMK, AH, WHO, HMH, FR, SK); and Department of Radiology, Philipps-University Marburg, Marburg, Germany (JTH, BK).
Search for more papers by this authorJohannes T. Heverhagen MD
From the Department of Neurology, Interdisciplinary Epilepsy Center, Philipps-University Marburg, Marburg, Germany (KH, AP, AH, KMK, AH, WHO, HMH, FR, SK); and Department of Radiology, Philipps-University Marburg, Marburg, Germany (JTH, BK).
Search for more papers by this authorAnja Haag MS
From the Department of Neurology, Interdisciplinary Epilepsy Center, Philipps-University Marburg, Marburg, Germany (KH, AP, AH, KMK, AH, WHO, HMH, FR, SK); and Department of Radiology, Philipps-University Marburg, Marburg, Germany (JTH, BK).
Search for more papers by this authorBoris Keil MS
From the Department of Neurology, Interdisciplinary Epilepsy Center, Philipps-University Marburg, Marburg, Germany (KH, AP, AH, KMK, AH, WHO, HMH, FR, SK); and Department of Radiology, Philipps-University Marburg, Marburg, Germany (JTH, BK).
Search for more papers by this authorKarl Martin Klein MD
From the Department of Neurology, Interdisciplinary Epilepsy Center, Philipps-University Marburg, Marburg, Germany (KH, AP, AH, KMK, AH, WHO, HMH, FR, SK); and Department of Radiology, Philipps-University Marburg, Marburg, Germany (JTH, BK).
Search for more papers by this authorAnke Hermsen MS
From the Department of Neurology, Interdisciplinary Epilepsy Center, Philipps-University Marburg, Marburg, Germany (KH, AP, AH, KMK, AH, WHO, HMH, FR, SK); and Department of Radiology, Philipps-University Marburg, Marburg, Germany (JTH, BK).
Search for more papers by this authorWolfgang H. Oertel MD
From the Department of Neurology, Interdisciplinary Epilepsy Center, Philipps-University Marburg, Marburg, Germany (KH, AP, AH, KMK, AH, WHO, HMH, FR, SK); and Department of Radiology, Philipps-University Marburg, Marburg, Germany (JTH, BK).
Search for more papers by this authorHajo M. Hamer MD
From the Department of Neurology, Interdisciplinary Epilepsy Center, Philipps-University Marburg, Marburg, Germany (KH, AP, AH, KMK, AH, WHO, HMH, FR, SK); and Department of Radiology, Philipps-University Marburg, Marburg, Germany (JTH, BK).
Search for more papers by this authorFelix Rosenow MD
From the Department of Neurology, Interdisciplinary Epilepsy Center, Philipps-University Marburg, Marburg, Germany (KH, AP, AH, KMK, AH, WHO, HMH, FR, SK); and Department of Radiology, Philipps-University Marburg, Marburg, Germany (JTH, BK).
Search for more papers by this authorSusanne Knake MD
From the Department of Neurology, Interdisciplinary Epilepsy Center, Philipps-University Marburg, Marburg, Germany (KH, AP, AH, KMK, AH, WHO, HMH, FR, SK); and Department of Radiology, Philipps-University Marburg, Marburg, Germany (JTH, BK).
Search for more papers by this authorKatja Hattemer MD
From the Department of Neurology, Interdisciplinary Epilepsy Center, Philipps-University Marburg, Marburg, Germany (KH, AP, AH, KMK, AH, WHO, HMH, FR, SK); and Department of Radiology, Philipps-University Marburg, Marburg, Germany (JTH, BK).
Search for more papers by this authorAnnika Plate MD
From the Department of Neurology, Interdisciplinary Epilepsy Center, Philipps-University Marburg, Marburg, Germany (KH, AP, AH, KMK, AH, WHO, HMH, FR, SK); and Department of Radiology, Philipps-University Marburg, Marburg, Germany (JTH, BK).
Search for more papers by this authorJohannes T. Heverhagen MD
From the Department of Neurology, Interdisciplinary Epilepsy Center, Philipps-University Marburg, Marburg, Germany (KH, AP, AH, KMK, AH, WHO, HMH, FR, SK); and Department of Radiology, Philipps-University Marburg, Marburg, Germany (JTH, BK).
Search for more papers by this authorAnja Haag MS
From the Department of Neurology, Interdisciplinary Epilepsy Center, Philipps-University Marburg, Marburg, Germany (KH, AP, AH, KMK, AH, WHO, HMH, FR, SK); and Department of Radiology, Philipps-University Marburg, Marburg, Germany (JTH, BK).
Search for more papers by this authorBoris Keil MS
From the Department of Neurology, Interdisciplinary Epilepsy Center, Philipps-University Marburg, Marburg, Germany (KH, AP, AH, KMK, AH, WHO, HMH, FR, SK); and Department of Radiology, Philipps-University Marburg, Marburg, Germany (JTH, BK).
Search for more papers by this authorKarl Martin Klein MD
From the Department of Neurology, Interdisciplinary Epilepsy Center, Philipps-University Marburg, Marburg, Germany (KH, AP, AH, KMK, AH, WHO, HMH, FR, SK); and Department of Radiology, Philipps-University Marburg, Marburg, Germany (JTH, BK).
Search for more papers by this authorAnke Hermsen MS
From the Department of Neurology, Interdisciplinary Epilepsy Center, Philipps-University Marburg, Marburg, Germany (KH, AP, AH, KMK, AH, WHO, HMH, FR, SK); and Department of Radiology, Philipps-University Marburg, Marburg, Germany (JTH, BK).
Search for more papers by this authorWolfgang H. Oertel MD
From the Department of Neurology, Interdisciplinary Epilepsy Center, Philipps-University Marburg, Marburg, Germany (KH, AP, AH, KMK, AH, WHO, HMH, FR, SK); and Department of Radiology, Philipps-University Marburg, Marburg, Germany (JTH, BK).
Search for more papers by this authorHajo M. Hamer MD
From the Department of Neurology, Interdisciplinary Epilepsy Center, Philipps-University Marburg, Marburg, Germany (KH, AP, AH, KMK, AH, WHO, HMH, FR, SK); and Department of Radiology, Philipps-University Marburg, Marburg, Germany (JTH, BK).
Search for more papers by this authorFelix Rosenow MD
From the Department of Neurology, Interdisciplinary Epilepsy Center, Philipps-University Marburg, Marburg, Germany (KH, AP, AH, KMK, AH, WHO, HMH, FR, SK); and Department of Radiology, Philipps-University Marburg, Marburg, Germany (JTH, BK).
Search for more papers by this authorSusanne Knake MD
From the Department of Neurology, Interdisciplinary Epilepsy Center, Philipps-University Marburg, Marburg, Germany (KH, AP, AH, KMK, AH, WHO, HMH, FR, SK); and Department of Radiology, Philipps-University Marburg, Marburg, Germany (JTH, BK).
Search for more papers by this authorDisclosure: The authors report no financial interest or conflicts of interest related to the manuscript.
J Neuroimaging 2011;21:16-23.
Abstract
ABSTRACT
BACKGROUND AND PURPOSE
The aim of this study was to investigate specific activation patterns and potential gender differences during mental rotation and to investigate whether functional magnetic resonance imaging (fMRI) and functional transcranial Doppler sonography (fTCD) lateralize hemispheric dominance concordantly.
METHODS
Regional brain activation and hemispheric dominance during mental rotation (cube perspective test) were investigated in 10 female and 10 male healthy subjects using fMRI and fTCD.
RESULTS
Significant activation was found in the superior parietal lobe, at the parieto-occipital border, in the middle and superior frontal gyrus bilaterally, and the right inferior frontal gyrus using fMRI. Men showed a stronger lateralization to the right hemisphere during fMRI and a tendency toward stronger right-hemispheric activation during fTCD. Furthermore, more activation in frontal and parieto-occipital regions of the right hemisphere was observed using fMRI. Hemispheric dominance for mental rotation determined by the 2 methods correlated well (P= .008), but did not show concordant results in every single subject.
CONCLUSIONS
The neural basis of mental rotation depends on a widespread bilateral network. Hemispheric dominance for mental rotation determined by fMRI and fTCD, though correlating well, is not always concordant. Hemispheric lateralization of complex cortical functions such as spatial rotation therefore should be investigated using multimodal imaging approaches, especially if used clinically as a tool for the presurgical evaluation of patients undergoing neurosurgery.
Supporting Information
Appendix 1. Activated and Deactivated Areas During Mental Rotation
Appendix 2. Gender Differences During Mental Rotation
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| JON_402_sm_AppendixS2.doc48.5 KB | Supporting info item |
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