Volume 20, Issue 1 pp. 103-105

Endocardial Transcatheter Stimulation of the AV Nodal Fat Pad: Stabilization of Rapid Ventricular Rate Response During Atrial Fibrillation in Left Ventricular Failure

STEFANO BIANCHI M.D.

STEFANO BIANCHI M.D.

Division of Cardiology, S. Giovanni Calibita Fatebenefratelli Hospital, Rome, Italy

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PIETRO ROSSI M.D.

PIETRO ROSSI M.D.

Department of Medicine, Belcolle Hospital, Viterbo, Italy

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ALBERTO DELLA SCALA M.S.

ALBERTO DELLA SCALA M.S.

Medtronic Italy, Sesto S. Giovanni, Milan, Italy

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LILIAN KORNET Ph.D.

LILIAN KORNET Ph.D.

Medtronic Bakken Research Center, Maastricht, the Netherlands

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First published: 29 December 2008
Citations: 16
Address for correspondence: Dr. Stefano Bianchi, M.D., via Capodistria, 4-00194 Rome, Italy. Fax: +390632814281; E-mail: [email protected]

Alberto Della Scala and Lilian Kornet are employees of Medtronic Inc.

Manuscript received 27 March 2008; Revised manuscript received 13 May 2008; Accepted for publication 19 May 2008.

Abstract

Introduction: Recent acute studies demonstrated that atrioventricular (AV) node vagal stimulation during atrial fibrillation (AF) decreases the mean ventricular rate, thus improving hemodynamics.

Methods and Results: We report a case of a woman with acute heart failure (HF), chronic AF with untreatable ventricular rapid response, in severe hypotensive state due to a cardiogenic shock. The patient underwent left ventricular (LV) pacemaker implantation and received 50 Hz AV node stimulation, delivered through a posteroseptal atrial lead, thus allowing a 100% pacing. Hemodynamics improvements allowed carvedilol titration; the rate was below 85 bpm after 4 days, then the atrial lead was removed.

Conclusions: This novel strategy may allow controlling the rapid AV response in patients undergoing pacemaker implantation.

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