BLOOD DONORS AND BLOOD COLLECTION

Blood donors with hereditary hemochromatosis

Anne S. Røsvik

From the Institute of Medicine and the Gades Institute, University of Bergen, Bergen; the Institute of Life Sciences, Ålesund University College, Ålesund; and the Department of Immunology and Transfusion Medicine, the Laboratory of Clinical Biochemistry, and the Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway.

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Rune J. Ulvik,

Rune J. Ulvik

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Tore Wentzel-Larsen,

Tore Wentzel-Larsen

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Tor Hervig,

Tor Hervig

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Anne S. Røsvik,

Anne S. Røsvik

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Rune J. Ulvik,

Rune J. Ulvik

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Tore Wentzel-Larsen,

Tore Wentzel-Larsen

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Tor Hervig,

Tor Hervig

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First published: 02 August 2010

https://doi.org/10.1111/j.1537-2995.2010.02627.x

Citations: 7

Anne Synnøve Røsvik, Institute of Life Sciences, Ålesund University College, N-6025 Ålesund, Norway; e-mail: [email protected].

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Abstract

BACKGROUND: The distribution of C282Y and H63D variants of the HFE gene was determined in donors with evidence of phenotypical hemochromatosis. The ferritin level and the effect of a donation on iron status in the different HFE genotypes were studied.

STUDY DESIGN AND METHODS: Forty women and 107 men with hemochromatosis were compared to HFE wild-type donors. The influence of a blood donation was assessed by the change in ferritin between two consecutive donations.

RESULTS: In women and men, 85 and 59%, respectively, were C282Y homozygote. None of the women had H63D alleles. There was no significant difference in the donation history or the ferritin level between the HFE genotypes. Donation frequencies were, respectively, 3.3 and 3.7 per year for women and men. The ferritin level was significantly higher in women with hemochromatosis, while in men it was similar compared to the respective wild types. The negative influence of a donation on iron status was similar in hemochromatotic and wild-type women, while men with hemochromatosis were significantly less vulnerable to a blood donation than genetically wild-type men.

CONCLUSION: Subjects with hemochromatosis are valuable as blood donors independent of their HFE genotype. In general, the ferritin level tended to be higher in those with hemochromatosis than in wild types. The negative influence of a blood donation on iron status was less in male donors with hemochromatosis than in wild types.

REFERENCES

1 Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, Dormishian F, Domingo R Jr, Ellis MC, Fullan A, Hinton LM, Jones NL, Kimmel BE, Kronmal GS, Lauer P, Lee VK, Loeb DB, Mapa FA, McClelland E, Meyer NC, Mintier GA, Moeller N, Moore T, Morikang E, Prass CE, Quintana L, Starnes SM, Schatzman RC, Brunke KJ, Drayna DT, Risch NJ, Bacon BR, Wolff RK. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 1996; 13: 399-408.
10.1038/ng0896-399
CAS PubMed Web of Science® Google Scholar
2 A simple genetic test identifies 90% of UK patients with haemochromatosis. The UK Haemochromatosis Consortium. Gut 1997; 41: 841-4.
10.1136/gut.41.6.841
PubMed Web of Science® Google Scholar
3 Jackson HA, Carter K, Darke C, Guttridge MG, Ravine D, Hutton RD, Napier JA, Worwood M. HFE mutations, iron deficiency and overload in 10,500 blood donors. Br J Haematol 2001; 114: 474-84.
10.1046/j.1365-2141.2001.02949.x
CAS PubMed Web of Science® Google Scholar
4 Boulton F, Collis D, Inskip H, Paes H, Garlick M. A study of the iron and HFE status of blood donors, including a group who failed the initial screen for anaemia. Br J Haematol 2000; 108: 434-9.
10.1046/j.1365-2141.2000.01878.x
CAS PubMed Web of Science® Google Scholar
5 Raddatz D, Legler T, Lynen R, Addicks N, Ramadori G. HFE genotype and parameters of iron metabolism in German first-time blood donors—evidence for an increased transferrin saturation in C282Y heterozygotes. Z Gastroenterol 2003; 41: 1069-76.
10.1055/s-2003-44299
CAS PubMed Web of Science® Google Scholar
6 Asberg A, Hveem K, Thorstensen K, Ellekjter E, Kannelønning K, Fjøsne U, Halvorsen TB, Smethurst HB, Sagen E, Bjerve KS. Screening for hemochromatosis: high prevalence and low morbidity in an unselected population of 65,238 persons. Scand J Gastroenterol 2001; 36: 1108-15.
10.1080/003655201750422747
CAS PubMed Web of Science® Google Scholar
7 Pennings G. Demanding pure motives for donation: the moral acceptability of blood donations by haemochromatosis patients. J Med Ethics 2005; 31: 69-72.
10.1136/jme.2002.001271
CAS PubMed Web of Science® Google Scholar
8 Conry-Cantilena C. Phlebotomy, blood donation, and hereditary hemochromatosis. Transfus Med Rev 2001; 15: 136-43.
10.1053/tm.2001.22616
CAS PubMed Web of Science® Google Scholar
9 Dockets Management Branch, FDA. “Guidance for industry: variances for blood collection from individuals with hereditary hemochromatosis;” availability. In: SERVICES DOHAH, FDA, PS McKeever, editor. Rockville (MD): FDA; 2001. Docket No. 00D-161, p. 1-5.
Google Scholar
10 Sanchez AM, Schreiber GB, Bethel J, McCurdy PR, Glynn SA, Williams AE, Gilcher R. Prevalence, donation practices, and risk assessment of blood donors with hemochromatosis. JAMA 2001; 286: 1475-81.
10.1001/jama.286.12.1475
CAS PubMed Web of Science® Google Scholar
11 Rosvik AS, Hervig T, Wentzel-Larsen T, Ulvik RJ. Iron status in Norwegian blood donors: comparison of iron status in new blood donors registered in 1993-1997 and in 2005-2006. Vox Sang 2009; 96: 49-55.
10.1111/j.1423-0410.2008.01115.x
CAS PubMed Web of Science® Google Scholar
12 QIAGEN. QIAamp DNA mini and blood mini handbook 11/2007. QIAGEN Düsseldorf, Germany. QIAGEN Norway, PB 4747 Nydalen, 0421 Oslo QIAGEN, 2007.
Google Scholar
13 Applied Biosystems, Life Technologies Corporation. Applied Biosystems (a periodical), 2008 [cited June 2009]. Available from: URL: http://www3.appliedbiosystems.com/AB_Home/index.htm 2008
Google Scholar
14 Venables WN, Smith DN, Team TR. An introduction to R. Vienna, Austria: R Foundation for Statistical Computing; 2008.
Google Scholar
15 Pinheiro JC, Bates DM. Mixed-effects models in S and S-PLUS. New York: Springer; 2000.
10.1007/978-1-4419-0318-1
PubMed Web of Science® Google Scholar
16 Worwood M, Darke C, Trenchard P. Hereditary haemochromatosis and blood donation. BMJ 1991; 302: 593.
10.1136/bmj.302.6776.593
CAS PubMed Web of Science® Google Scholar
17 Levstik M, Adams PC. Eligibility and exclusion of hemochromatosis patients as voluntary blood donors. Can J Gastroenterol 1998; 12: 61-3.
10.1155/1998/590428
CAS PubMed Web of Science® Google Scholar
18 Leitman SF, Browning JN, Yau YY, Mason G, Klein HG, Conry-Cantilena C, Bolan CD. Hemochromatosis subjects as allogeneic blood donors: a prospective study. Transfusion 2003; 43: 1538-44.
10.1046/j.1537-2995.2003.00570.x
PubMed Web of Science® Google Scholar
19 Rosvik AS, Ulvik RJ, Wentzel-Larsen T, Hervig T. The effect of blood donation frequency on iron status. Transfus Apher Sci 2009; 41: 165-9.
10.1016/j.transci.2009.09.017
CAS PubMed Web of Science® Google Scholar
20 Newman B. Hemochromatosis blood donor programs: marginal for the red blood cell supply but potentially good for patient care. Transfusion 2004; 44: 1535-7; author reply 1537-8.
10.1111/j.0041-1132.2004.00420_1.x
PubMed Web of Science® Google Scholar
21 Lynch SR, Skikne BS, Cook JD. Food iron absorption in idiopathic hemochromatosis. Blood 1989; 74: 2187-93.
10.1182/blood.V74.6.2187.bloodjournal7462187
CAS PubMed Web of Science® Google Scholar
22 Borch-Iohnsen B, Sandstad B, Asberg A. Iron status among 3005 women aged 20-55 years in Central Norway: the Nord-Trondelag Health Study (the HUNT study). Scand J Clin Lab Invest 2005; 65: 45-54.
10.1080/00365510510013541
CAS PubMed Web of Science® Google Scholar
23 Eskeland B, Baerheim A, Ulvik R, Hunskaar S. Influence of mild infections on iron status parameters in women of reproductive age. Scand J Prim Health Care 2002; 20: 50-6.
10.1080/028134302317282752
PubMed Web of Science® Google Scholar
24 Birgegard G, Hallgren R, Killander A, Strömberg A, Venge P, Wide L. Serum ferritin during infection. A longitudinal study. Scand J Haematol 1978; 21: 333-40.
10.1111/j.1600-0609.1978.tb00374.x
PubMed Web of Science® Google Scholar
25 Worwood M. Serum ferritin. In: A Jacobs, M Worwood, editors. Iron in biochemistry and medicine. London and New York: Academic Press; 1980. p. 203-44.
Web of Science® Google Scholar

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Volume50, Issue8

August 2010

Pages 1787-1793

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