Migralepsy: A call for a revision of the definition
Grazia Sances
Headache Unit, IRCCS “C. Mondino Institute of Neurology” Foundation, Pavia, Italy
Search for more papers by this authorElena Guaschino
Headache Unit, IRCCS “C. Mondino Institute of Neurology” Foundation, Pavia, Italy
Search for more papers by this authorPiero Perucca
Unit of Sleep Medicine and Epilepsy, IRCCS “C. Mondino Institute of Neurology” Foundation, Pavia, Italy
Search for more papers by this authorMarta Allena
Headache Unit, IRCCS “C. Mondino Institute of Neurology” Foundation, Pavia, Italy
Search for more papers by this authorNatascia Ghiotto
Neurosonology Service, IRCCS “C. Mondino Institute of Neurology” Foundation, Pavia, Italy
Search for more papers by this authorRaffaele Manni
Unit of Sleep Medicine and Epilepsy, IRCCS “C. Mondino Institute of Neurology” Foundation, Pavia, Italy
Search for more papers by this authorGrazia Sances
Headache Unit, IRCCS “C. Mondino Institute of Neurology” Foundation, Pavia, Italy
Search for more papers by this authorElena Guaschino
Headache Unit, IRCCS “C. Mondino Institute of Neurology” Foundation, Pavia, Italy
Search for more papers by this authorPiero Perucca
Unit of Sleep Medicine and Epilepsy, IRCCS “C. Mondino Institute of Neurology” Foundation, Pavia, Italy
Search for more papers by this authorMarta Allena
Headache Unit, IRCCS “C. Mondino Institute of Neurology” Foundation, Pavia, Italy
Search for more papers by this authorNatascia Ghiotto
Neurosonology Service, IRCCS “C. Mondino Institute of Neurology” Foundation, Pavia, Italy
Search for more papers by this authorRaffaele Manni
Unit of Sleep Medicine and Epilepsy, IRCCS “C. Mondino Institute of Neurology” Foundation, Pavia, Italy
Search for more papers by this authorSummary
Migralepsy is an ill-defined nosologic entity, with only a few cases described in the literature. In the 2004 International Classification for Headache Disorders (ICHD-II), the International Headache Society proposed that the following diagnostic criteria should be met: (1) migraine fulfilling criteria for 1.2 Migraine with aura (MA) and (2) a seizure fulfilling diagnostic criteria for one type of epileptic attack occurs during or within 1 h after a migraine aura. Herein, by presenting a case with symptoms suggestive of migralepsy and by reviewing all previous cases described in the literature, we discuss the challenges of differentiating this condition from epileptic seizures, as well as the inaccuracy of the current ICHD-II definition.
Supporting Information
Table S1. The Visual Aura Rating Scale (VARS) score in our patient.
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References
- Anderman F. (1987) Clinical features of migraine epilepsy syndromes. In F Andermann, E Lugaresi (Eds) Migraine and epilepsy. Butterworths, Boston, pp. 3–30.
- Barré M, Hamelin S, Minotti L, Kahane P, Vercueil L. (2008) [Epileptic seizure and migraine visual aura: revisiting migralepsy]. Rev Neurol (Paris) 164: 246–252.
- Basser LS. (1969) The relation of migraine and epilepsy. Brain 92: 285–300.
- Eriksen MK, Thomsen LL, Olesen J. (2005) The Visual Aura Rating Scale (VARS) for migraine aura diagnosis. Cephalalgia 25: 801–810.
- Friedenberg S, Dodick DW. (2000) Migraine-associated seizure: a case of reversible MRI abnormalities and persistent nondominant hemisphere syndrome. Headache 40: 487–490.
- Gilliam FG, Perucca P. (2008) Beyond seizure reduction. In P Kahane, A Berg, W Losher, D Nordli, E Perucca ((Eds)) Drug resistant epilepsies. John Libbey Eurotext, Surrey, United Kingdom, pp. 171–186.
- International Headache Society. (2004) The International Classification of Headache Disorders: 2nd edition. Cephalalgia 24 suppl 1: 9–160.
- Lennox WG, Lennox MA. (1960) Epilepsy and related disorders. Little, Brown & Company, Boston.
- Maggioni F, Mampreso E, Ruffatti S, Viaro F, Lunardelli V, Zanchin G. (2008) Migralepsy: is the current definition too narrow? Headache 48: 1129–1132.
- Marks DA, Ehrenberg BL. (1993) Migraine-related seizures in adults with epilepsy, with EEG correlation. Neurology 43: 2476–2483.
- Mateo I, Foncea N, Vicente I, Gomez Beldarrain M, Garcia-Monco JC. (2004) Migraine-associated seizures with recurrent and reversible magnetic resonance imaging abnormalities. Headache 44: 265–270.
- Merlino G, Valente M, D’Anna S, Gigli GL. (2007) Seizures with prolonged EEG abnormalities during an attack of migraine without aura. Headache 47: 919–922.
- Milligan TA, Bromfield E. (2005) A case of “migralepsy”. Epilepsia 46(suppl 10): 2–6.
- Niedermeyer E. (1993) Migraine-triggered epilepsy. Clin Electroencephalogr 24: 37–43.
- Panayiotopoulos CP. (1999a) Differentiating occipital epilepsies from migraine with aura, acephalgic migraine and basilar migraine. In CP Panayiotopoulos (Ed) Benign childhood partial seizures and related epileptic syndromes. John Libbey & Company Ltd, London, pp. 281–302.
- Panayiotopoulos CP. (1999b) Visual phenomena and headache in occipital epilepsy: a review, a systematic study and differentiation from migraine. Epileptic Disord 1: 205–216.
- Parisi P, Kasteleijn-Nolst Trenite DG, Piccioli M, Pelliccia A, Luchetti A, Buttinelli C, Villa MP. (2007) A case with atypical childhood occipital epilepsy “Gastaut type”: an ictal migraine manifestation with a good response to intravenous diazepam. Epilepsia 48: 2181–2186.
- Parisi P, Piccioli M, De Sneeuw S, De Kovel C, Van Nieuwenhuizen O, Buttinelli C, Villa MP, Kasteleijn-Nolst Trenite DG. (2008) Redefining headache diagnostic criteria as epileptic manifestation? Cephalalgia 28: 408–409.
- Parisi P. (2009) Why is migraine rarely, and not usually, the sole ictal epileptic manifestation? Seizure 18: 309–312.
- Piccioli M, Parisi P, Tisei P, Villa MP, Buttinelli C, Kasteleijn-Nolst Trenite DG. (2009) Ictal headache and visual sensitivity. Cephalalgia 29: 194–203.
- Russell MB, Olesen J. (1996) A nosographic analysis of the migraine aura in a general population. Brain 119: 355–361.
- Terzano MG, Parrino L, Pietrini V, Galli L. (1993) Migraine-epilepsy syndrome: intercalated seizures in benign occipital epilepsy. In F Andermann, A Beaumanoir, L Mira, J Roger, CA Tassinari (Eds) Occipital seizures and epilepsies in children. John Libbey & Company Ltd, London, pp. 93–99.
- Velioglu SK, Ozmenoglu M. (1999) Migraine-related seizures in an epileptic population. Cephalalgia 19: 797–801.