Address correspondence and reprint requests to Dr. Y. Hori at Department of Physiology, Okayama University Medical School, 2–5–1 Shikata-cho, Okayama 700, Japan.Search for more papers by this author

Yasushi Hayashi,

Yasushi Hayashi

Departments of Physiology, Okayama University Medical School, Okayama, Japan

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Yukio Hattori,

Yukio Hattori

Departments of Physiology, Okayama University Medical School, Okayama, Japan

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Akiyoshi Moriwaki,

Akiyoshi Moriwaki

Departments of Physiology, Okayama University Medical School, Okayama, Japan

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Kiyomi Saeki,

Kiyomi Saeki

Pharmacology, Okayama University Medical School, Okayama, Japan

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Yasuo Hori,

Corresponding Author

Yasuo Hori

Departments of Physiology, Okayama University Medical School, Okayama, Japan

First published: September 1989

https://doi.org/10.1111/j.1471-4159.1989.tb11805.x

Citations: 22

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Abstract

Concentrations of the polyamines putrescine, spermidine, and spermine were investigated in the left and right amygdala and in the remaining cerebrum, in which kindling was induced by repeated application of electrical stimulation of the left amygdala of rats. In kindled rats, the concentrations of spermidine and spermine increased slightly, but elevations did not reach significant levels in any brain regions. The most profound increase was detected in the putrescine concentration in all parts of the cerebrum 1–8 h after the final stimulation. These results suggest that the increases in concentrations of polyamines, particularly of putrescine, are involved in the pathogenesis of amygdaloid kindling.

Abbreviations used:

ANOVA: analysis of variance
ODC: ornithine decarboxylase

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Volume53, Issue3

September 1989

Pages 986-988

Changes in Polyamine Concentrations in Amygdaloid-Kindled Rats

Abstract

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Changes in Polyamine Concentrations in Amygdaloid-Kindled Rats

Abstract

Abbreviations used:

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