Lack of association between the 3092 T→C Clock gene polymorphism and cluster headache
Corresponding Author
I Rainero
Neurology III, Headache Centre, Department of Neuroscience
Dr Innocenzo Rainero, Neurology III, Headache Centre, Department of Neuroscience, University of Turin, Via Cherasco 15, 10126 Torino, Italy. Tel. + 39 011 663 8510, e-mail [email protected]Search for more papers by this authorC Rivoiro
Neurology III, Headache Centre, Department of Neuroscience
Search for more papers by this authorS Gallone
SCDU, Medical Genetics, University of Torino, Torino, Italy
Search for more papers by this authorW Valfrè
Neurology III, Headache Centre, Department of Neuroscience
Search for more papers by this authorM Ferrero
Neurology III, Headache Centre, Department of Neuroscience
Search for more papers by this authorG Angilella
SCDU, Medical Genetics, University of Torino, Torino, Italy
Search for more papers by this authorE Rubino
Neurology III, Headache Centre, Department of Neuroscience
Search for more papers by this authorP De Martino
Neurology III, Headache Centre, Department of Neuroscience
Search for more papers by this authorL Savi
Neurology III, Headache Centre, Department of Neuroscience
Search for more papers by this authorR Lo Giudice
Neurology III, Headache Centre, Department of Neuroscience
Search for more papers by this authorL Pinessi
Neurology III, Headache Centre, Department of Neuroscience
Search for more papers by this authorCorresponding Author
I Rainero
Neurology III, Headache Centre, Department of Neuroscience
Dr Innocenzo Rainero, Neurology III, Headache Centre, Department of Neuroscience, University of Turin, Via Cherasco 15, 10126 Torino, Italy. Tel. + 39 011 663 8510, e-mail [email protected]Search for more papers by this authorC Rivoiro
Neurology III, Headache Centre, Department of Neuroscience
Search for more papers by this authorS Gallone
SCDU, Medical Genetics, University of Torino, Torino, Italy
Search for more papers by this authorW Valfrè
Neurology III, Headache Centre, Department of Neuroscience
Search for more papers by this authorM Ferrero
Neurology III, Headache Centre, Department of Neuroscience
Search for more papers by this authorG Angilella
SCDU, Medical Genetics, University of Torino, Torino, Italy
Search for more papers by this authorE Rubino
Neurology III, Headache Centre, Department of Neuroscience
Search for more papers by this authorP De Martino
Neurology III, Headache Centre, Department of Neuroscience
Search for more papers by this authorL Savi
Neurology III, Headache Centre, Department of Neuroscience
Search for more papers by this authorR Lo Giudice
Neurology III, Headache Centre, Department of Neuroscience
Search for more papers by this authorL Pinessi
Neurology III, Headache Centre, Department of Neuroscience
Search for more papers by this authorAbstract
Recent studies suggested that genetic factors play a role in cluster headache (CH). However, the type and the number of genes involved in the disease are still unclear. We performed an association study in a cohort of Italian CH patients to evaluate whether a particular allele or genotype of the Clock gene would modify the occurrence and the clinical features of the disease. One hundred and seven CH patients, diagnosed according to the International Classification of Headache Disorders, 2nd Edition, (ICHD-II) criteria, and 210 healthy age, sex and ethnicity-matched controls were genotyped for the 3092 T→C Clock gene polymorphism (also known as 3111 T→C). Phenotype and allele frequencies were similarly distributed in CH patients and controls. The clinical features of the disease were not significantly influenced by different genotypes. In conclusion, our study suggests that the 3092 T→C polymorphism of the Clock gene is unlikely to play an important role in cluster headache.
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