Eriks Jankevics, Latvian Biomedical Research and Study Centre, Ratsupites 1, Riga, LV-1067 Latvia (tel.: +371 67808210; fax: +371 67442407; e-mail: [email protected]).

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Abstract

Background: Essential tremor (ET) is the most prevalent inherited movement disorder. ET has been mapped on chromosomes 2 and 3, but causative genes are not known.

Methods: We genotyped 16 microsatellite markers in a case–control cohort consisting of 104 patients and 116 controls.

Results: No significant difference between allele frequencies was found. The highest difference of frequencies was found in allele 171 of the marker D2S220 (OR 0.13, 95% CI 0.02–1.03, P = 0.05). In addition, we investigated the distribution of suspected disease gene DRD3 Ser9Gly polymorphism in the same patients and controls.

Conclusion: There was not a significant difference in genotypic distribution between disease group and control subjects (χ²=2.8, P = 0.25).

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Volume15, Issue9

September 2008

Pages 988-990

Case–control study of patients with essential tremor in Latvia

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Case–control study of patients with essential tremor in Latvia

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